[1]俞卫铿.腹腔镜胆囊切除术治疗胆囊结石伴慢性胆囊炎患者临床疗效[J].医学信息,2022,35(17):110-113.[doi:10.3969/j.issn.1006-1959.2022.17.029]
　YU Wei-keng.Clinical Effect of Laparoscopic Cholecystectomy in Treatment of Patients with Gallstone and Chronic Cholecystitiss[J].Journal of Medical Information,2022,35(17):110-113.[doi:10.3969/j.issn.1006-1959.2022.17.029]
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腹腔镜胆囊切除术治疗胆囊结石伴慢性胆囊炎患者临床疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年17期
页码:
110-113
栏目:
临床研究
出版日期:
2022-09-01

文章信息/Info

Title:
Clinical Effect of Laparoscopic Cholecystectomy in Treatment of Patients with Gallstone and Chronic Cholecystitiss
文章编号:
1006-1959（2022）17-0110-04
作者:
俞卫铿
（上饶市广丰区中医院普外科，江西 上饶 334600）
Author(s):
YU Wei-keng
(Department of General Surgery,Guangfeng Hospital of Traditional Chinese Medicine,Shangrao 334600,Jiangxi,China)
关键词:
胆囊结石; 慢性胆囊炎; 腹腔镜胆囊切除术; 应激反应; 肝功能
Keywords:
Gallbladder stones; Chronic cholecystitis; Laparoscopic cholecystectomy; Stress reaction; Liver function
分类号:
R657.4
DOI:
10.3969/j.issn.1006-1959.2022.17.029
文献标志码:
A
摘要:
目的 探究腹腔镜胆囊切除术（LC）治疗胆囊结石伴慢性胆囊炎患者的临床疗效。方法 选取2018年10月-2021年10月于江西省上饶市广丰区中医院行LC治疗的68例胆囊结石伴慢性胆囊炎患者，按照随机数字表法分为对照组与观察组，每组34例。对照组采用小切口胆囊切除术治疗，观察组则应用LC治疗，比较两组手术相关指标、氧化应激指标[超氧化物岐化酶（SOD）、还原型谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）]、炎性因子[C反应蛋白（CRP）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）]、肝功能[谷氨酰转肽酶（GGT）、天冬氨酸转氨酶（AST）、丙氨酸转移酶（ALT）]及术后并发症。结果 观察组手术时间、术后肛门排气时间及住院时间均短于对照组，且术后出血量少于对照组（P＜0.05）；两组治疗后SOD、GSH-Px水平下降，MDA水平升高，但观察组SOD、GSH-Px高于对照组，MDA低于对照组（P＜0.05）；两组治疗后CRP、IL-6、TNF-α、GGT、AST、ALT水平均高于治疗前，但观察组低于对照组（P＜0.05）；观察组并发症发生率低于对照组（P＜0.05）。结论 LC可缩短胆囊结石伴慢性胆囊炎患者的手术时长及术后恢复时间，减少出血量，且氧化应激及炎症反应小，术后肝损伤低。
Abstract:
Objective To explore the clinical efficacy of laparoscopic cholecystectomy (LC) in the treatment of patients with gallstones and chronic cholecystitis.Methods A total of 68 patients with cholecystolithiasis and chronic cholecystitis who underwent LC in Guangfeng District Hospital of Traditional Chinese Medicine, Shangrao City, Jiangxi Province from October 2018 to October 2021 were selected and divided into a control group and an observation group according to the random number table method, with 34 cases in each group. The control group was treated with small incision cholecystectomy, while the observation group was treated with LC. The operation-related indexes, oxidative stress indexes [superoxide dismutase (SOD), reduced glutathione peroxidase (GSH-Px), malondialdehyde (MDA)], inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], liver function [glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT)] and postoperative complications were compared between the two groups.Results The operation time, postoperative anal exhaust time and hospitalization time of the observation group were shorter than those of the control group, and the postoperative bleeding volume was less than that of the control group(P<0.05). After treatment, the levels of SOD and GSH-Px in the two groups were decreased, and the level of MDA was increased, while the levels of SOD and GSH-Px in the observation group were higher than those in the control group, and the level of MDA was lower than that in the control group (P<0.05). After treatment, the levels of CRP, IL-6, TNF-α, GGT, AST and ALT in the two groups were higher than those before treatment, while those in the observation group was lower than the control groupt(P<0.05). The incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion LC can shorten the operation time and postoperative recovery time of patients with gallstones and chronic cholecystitis, reduce the amount of bleeding, and the oxidative stress and inflammatory response are small, and the postoperative liver injury is low.

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更新日期/Last Update: 1900-01-01