[1]王东旭.华法林抗凝治疗与CYP2C9基因多态性的研究[J].医学信息,2023,36(02):176-179.[doi:10.3969/j.issn.1006-1959.2023.02.039]
 WANG Dong-xu.Research in Warfarin Anticoagulant Treatment and Genetic Polymorphisms of CYP2C9[J].Journal of Medical Information,2023,36(02):176-179.[doi:10.3969/j.issn.1006-1959.2023.02.039]
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华法林抗凝治疗与CYP2C9基因多态性的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年02期
页码:
176-179
栏目:
综述
出版日期:
2023-01-15

文章信息/Info

Title:
Research in Warfarin Anticoagulant Treatment and Genetic Polymorphisms of CYP2C9
文章编号:
1006-1959(2023)02-0176-04
作者:
王东旭
(中国医学科学院/北京协和医学院/国家心血管病中心/阜外医院心内科,北京 100037)
Author(s):
WANG Dong-xu
(Department of Cardiology,Chinese Academy of Medical Sciences/Peking Union Medical College/National Center for Cardiovascular Diseases/Fuwai Hospital,Beijing 100037,China)
关键词:
华法林CYP2C9药物基因组学
Keywords:
WarfarinCYP2C9Pharmacogenomics
分类号:
R973+.2
DOI:
10.3969/j.issn.1006-1959.2023.02.039
文献标志码:
A
摘要:
华法林是一种口服抗凝药物,其可抑制维生素K依赖的凝血因子合成,改变血液高凝状态,预防血栓形成,适用于防治血栓栓塞性疾病。华法林稳态剂量受多种遗传和非遗传因素影响,其中遗传因素是影响华法林抗凝效果的最重要因素。CYP2C9基因的遗传多态性最为丰富,且研究发现,CYP2C9基因变异对华法林稳态剂量有着重要影响。本文就CYP2C9基因对华法林的药物代谢的影响及CYP2C9基因多态性在华法林抗凝治疗中的意义作一综述,以期为临床上基因指导华法林治疗提供依据。
Abstract:
Warfarin is an oral anticoagulant drug, which can inhibit the synthesis of vitamin K-dependent coagulation factors, change the hypercoagulable state of blood, prevent thrombosis, and is suitable for the prevention and treatment of thromboembolic diseases. The steady-state dose of warfarin is affected by many genetic and non-genetic factors, among which genetic factors are the most important factors affecting the anticoagulant effect of warfarin. The genetic polymorphism of CYP2C9 gene is the most abundant, and the study found that CYP2C9 gene mutation has an important influence on the steady-state dose of warfarin. This article reviews the effect of CYP2C9 gene on warfarin metabolism and the significance of CYP2C9 gene polymorphism in warfarin anticoagulation therapy, in order to provide a basis for clinical gene guidance of warfarin therapy.

参考文献/References:

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更新日期/Last Update: 1900-01-01