[1]周 瑞,张雪芬,张 宁,等.抗生素对早产儿肠道菌群影响的研究[J].医学信息,2023,36(03):177-180.[doi:10.3969/j.issn.1006-1959.2023.03.039]
 ZHOU Rui,ZHANG Xue-fen,ZHANG Ning,et al.Effect of Antibiotics on Intestinal Microflora in Premature Infants[J].Journal of Medical Information,2023,36(03):177-180.[doi:10.3969/j.issn.1006-1959.2023.03.039]
点击复制

抗生素对早产儿肠道菌群影响的研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年03期
页码:
177-180
栏目:
综述
出版日期:
2023-02-01

文章信息/Info

Title:
Effect of Antibiotics on Intestinal Microflora in Premature Infants
文章编号:
1006-1959(2023)03-0177-04
作者:
周 瑞张雪芬张 宁
(1.甘肃中医药大学护理学院护理系,甘肃 兰州 730000;2.甘肃省妇幼保健院护理部,甘肃 兰州 730050)
Author(s):
ZHOU RuiZHANG Xue-fenZHANG Ninget al.
(1.Department of Nursing,School of Nursing,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;2.Department of Nursing,Gansu Province Maternal and Child Health Hospital,Lanzhou 730050,Gansu,China)
关键词:
抗生素早产儿肠道菌群
Keywords:
AntibioticsPremature infantsIntestinal flora
分类号:
R722.6
DOI:
10.3969/j.issn.1006-1959.2023.03.039
文献标志码:
A
摘要:
早产儿由于免疫系统发育不成熟,自身抵抗力和免疫力弱,因而易发生院内感染。且在新生儿重症监护病房(NICU)中,早产儿经验性、预防性抗生素的使用情况较为普遍,过早使用抗生素易引起早产儿肠道菌群失调、肠道致病菌增加,还易引起消化系统疾病,并与早产儿败血症、过敏及神经精神性的疾病发生密切相关。因此,本文从抗生素使用对早产儿肠道菌群的影响进行综述。
Abstract:
Neonatal infants have a high incidence of nosocomial infection due to their immature immune system, weak resistance and immunity. Experimental and preventive antibiotics are commonly used in neonatal intensive care units (NICU). Early use of antibiotics is likely to cause intestinal flora imbalance and increase of intestinal pathogenic bacteria in premature infants. It is also easy to cause digestive system diseases and is closely related to sepsis, allergy and neuropsychiatric diseases in premature infants. Therefore, this article reviews the effects of antibiotic use on intestinal flora in premature infants.

参考文献/References:

[1]张坤,樊赛男,吕安平,等.生命早期肠道菌群建立的影响因素[J].临床与病理杂志,2020,40(4):1028-1032.[2]Zou ZH,Liu D,Li HD,et al.Prenatal and postnatal antibiotic exposure influences the gut microbiota of preterm infants in neonatal intensive care units[J].Ann Clin Microbiol Antimicrob,2018,17(1):9.[3]Reed BD,Schibler KR,Deshmukh H,et al.The Impact of Maternal Antibiotics on Neonatal Disease[J].J Pediatr,2018,197:97-103.e3.[4]Lee MJ,Sayers AE,Drake TM,et al.Malnutrition,nutritional interventions and clinical outcomes of patients with acute small bowel obstruction: results from a national,multicentre,prospective audit[J].BMJ Open,2019,9(7):e029235.[5]Greenwood C,Morrow AL,Lagomarcino AJ,et al.Early empiric antibiotic use in preterm infants is associated with lower bacterial diversity and higher relative abundance of Enterobacter[J].J Pediatr,2014,165(1):23-29.[6]Puopolo KM,Mukhopadhyay S,Hansen NI,et al.Identification of Extremely Premature Infants at Low Risk for Early-Onset Sepsis[J].Pediatrics,2017,140(5):e20170925.[7]Rajar P,Saugstad OD,Berild D,et al.Antibiotic Stewardship in Premature Infants: A Systematic Review[J].Neonatology,2020,117(6):673-686.[8]Willis KA,Siefker DT,Aziz MM,et al.Perinatal maternal antibiotic exposure augments lung injury in offspring in experimental bronchopulmonary dysplasia[J].Am J Physiol Lung Cell Mol Physiol,2020,318(2):L407-L418.[9]Zhong Y,Zhang Y,Wang Y,et al.Maternal antibiotic exposure during pregnancy and the risk of allergic diseases in childhood: A meta-analysis[J].Pediatr Allergy Immunol,2021,32(3):445-456.[10]Cantey JB,Wozniak PS,Sánchez PJ.Prospective surveillance of antibiotic use in the neonatal intensive care unit: results from the SCOUT study[J].Pediatr Infect Dis J,2015,34(3):267-272.[11]Rinninella E,Raoul P,Cintoni M,et al.What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment,Diet, and Diseases[J].Microorganisms,2019,7(1):14.[12]Unger S,Stintzi A,Shah P,et al.Gut microbiota of the very-low-birth-weight infant[J].Pediatr Res,2015,77(1-2):205-213.[13]Lee JK,Hern Tan LT,Ramadas A,et al.Exploring the Role of Gut Bacteria in Health and Disease in Preterm Neonates[J].Int J Environ Res Public Health,2020,17(19):6963.[14]应文跃,徐慧松.抗生素暴露对早产儿肠道菌群及2岁时过敏性疾病的影响[J].中国微生态学杂志2020,32(12):1386-1390,1396.[15]Liu CJ,Liang X,Niu ZY,et al.Is the delivery mode a critical factor for the microbial communities in the meconium?[J].EBioMedicine,2019,49:354-363.[16]Wang J,Zheng J,Shi W,et al.Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus[J].Gut,2018,67(9):1614-1625.[17]Underwood MA,Sohn K.The Microbiota of the Extremely Preterm Infant[J].Clin Perinatol,2017,44(2):407-427.[18]Zwittink RD,van Zoeren-Grobben D,Renes IB,et al.Dynamics of the bacterial gut microbiota in preterm and term infants after intravenous amoxicillin/ceftazidime treatment[J].BMC Pediatr,2020,20(1):195.[19]丁再萌,祖婷.早产儿肠道微生态变化及其与胎龄、出生体质量的关系[J].中国微生态学杂志,2021,33(11):1264-1268.[20]Underwood MA.Probiotics and the prevention of necrotizing enterocolitis[J].J Pediatr Surg,2019,54(3):405-412.[21]Lu J,Claud EC.Connection between gut microbiome and brain development in preterm infants[J].Dev Psychobiol,2019,61(5):739-751.[22]Cortese F,Scicchitano P,Gesualdo M,et al.Early and Late Infections in Newborns: Where Do We Stand? A Review[J].Pediatr Neonatol,2016,57(4):265-273.[23]王铭杰,岳少杰,林锦,等.湖南省极低/超低出生体重儿抗生素使用多中心调查报告[J].中国当代儿科杂志,2020,22(6): 561-566.[24]Iizumi T,Battaglia T,Ruiz V,et al.Gut Microbiome and Antibiotics[J].Arch Med Res,2017,48(8):727-734.[25]Gasparrini AJ,Crofts TS,Gibson MK,et al.Antibiotic perturbation of the preterm infant gut microbiome and resistome[J].Gut Microbes,2016,7(5):443-449.[26]赵琪,芦起.新生儿抗生素暴露对肠道菌群及临床结局的影响[J].临床儿科杂志,2019,37(8):628-631.[27]Gibson MK,Crofts TS,Dantas G.Antibiotics and the developing infant gut microbiota and resistome[J].Curr Opin Microbiol,2015,27:51-56.[28]Zhu D,Xiao S,Yu J,et al.Effects of One-Week Empirical Antibiotic Therapy on the Early Development of Gut Microbiota and Metabolites in Preterm Infants[J].Sci Rep,2017,7(1):8025.[29]Russell JT,Lauren Ruoss J,de la Cruz D,et al.Antibiotics and the developing intestinal microbiome,metabolome and inflammatory environment in a randomized trial of preterm infants[J].Sci Rep,2021,11(1):1943.[30]孙倩,王政力,刘晓晨,等.广谱抗生素疗程对极低出生体重儿粪便肠道菌群和短链脂肪酸影响的前瞻性研究[J].中国当代儿科杂志,2021,23(10):1008-1014.[31]Cantey JB,Pyle AK,Wozniak PS,et al.Early Antibiotic Exposure and Adverse Outcomes in Preterm,Very Low Birth Weight Infants[J].J Pediatr,2018,203:62-67.[32]Dardas M,Gill SR,Grier A,et al.The impact of postnatal antibiotics on the preterm intestinal microbiome[J].Pediatr Res,2014,76(2):150-158.[33]杨凯蒂.抗生素疗程对早产儿肠道菌群与免疫功能的影响及新生儿早发型败血症生物标志物筛选研究[D].重庆:重庆医科大学,2021.

相似文献/References:

[1]吴君华,吴友茹,李 丹.血清降钙素原在AECOPD抗感染治疗中的应用价值研究[J].医学信息,2018,31(02):74.[doi:10.3969/j.issn.1006-1959.2018.02.025]
 WU Jun-hua,WU You-ru,LI Dan.Study on the Application Value of Serum Calcitonin in the Anti Infection Treatment of AECOPD[J].Journal of Medical Information,2018,31(03):74.[doi:10.3969/j.issn.1006-1959.2018.02.025]
[2]石福建.N-CPAP模式和NIPPV对呼吸窘迫综合征早产儿心功能的影响分析[J].医学信息,2018,31(02):91.[doi:10.3969/j.issn.1006-1959.2018.02.031]
 SHI Fu-jian.Effect of N-CPAP Mode and NPIPPV on Cardiac Function in Preterm Infants with Respiratory Distress Syndrome[J].Journal of Medical Information,2018,31(03):91.[doi:10.3969/j.issn.1006-1959.2018.02.031]
[3]刘亿荣,吴开锋,曾春英,等.早产儿肠道喂养方式对住院期间变应性疾病的影响[J].医学信息,2018,31(02):105.[doi:10.3969/j.issn.1006-1959.2018.02.037]
 LIU Yi-Rong,WU Kai-Feng,ZENG Chun-Ying,et al.Effects of Gut Feeding on Preterm Infant Allergic Diseases during Hospitalization[J].Journal of Medical Information,2018,31(03):105.[doi:10.3969/j.issn.1006-1959.2018.02.037]
[4]赵 菁.脐带不同结扎方式对新生儿影响的研究进展[J].医学信息,2018,31(04):53.[doi:10.3969/j.issn.1006-1959.2018.04.017]
 ZHAO Jing.Research Progress on the Influence of Different Umbilical Cord Ligation on Neonates[J].Journal of Medical Information,2018,31(03):53.[doi:10.3969/j.issn.1006-1959.2018.04.017]
[5]王晋蜀,黄梦雅,赵明丹,等.泌尿生殖道支原体感染检测、鉴定及耐药性分析[J].医学信息,2018,31(16):98.[doi:10.3969/j.issn.1006-1959.2018.16.029]
 WANG Jin-shu,HUANG Meng-ya,ZHAO Ming-dan,et al.Detection,Identification and Drug Resistance Analysis of Urogenital Mycoplasma Infection[J].Journal of Medical Information,2018,31(03):98.[doi:10.3969/j.issn.1006-1959.2018.16.029]
[6]于文清.下呼吸道感染病原菌分布及耐药性分析[J].医学信息,2018,31(24):74.[doi:10.3969/j.issn.1006-1959.2018.24.019]
 YU Wen-qing.Analysis of Distribution and Drug Resistance of Pathogenic Bacteria in Lower Respiratory Tract Infection[J].Journal of Medical Information,2018,31(03):74.[doi:10.3969/j.issn.1006-1959.2018.24.019]
[7]张佳佳,李 庆,王 同.中性粒细胞CD64指数指导慢性阻塞性肺疾病急性加重期抗生素应用的探讨[J].医学信息,2019,32(07):78.[doi:10.3969/j.issn.1006-1959.2019.07.023]
 ZHANG Jia-jia,LI Qing,WANG Tong.The Application of Neutrophil CD64 Index in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J].Journal of Medical Information,2019,32(03):78.[doi:10.3969/j.issn.1006-1959.2019.07.023]
[8]董显燕,高李华.BNP及NT-proBN诊断早产儿动脉导管未闭临床分析[J].医学信息,2019,32(12):70.[doi:10.3969/j.issn.1006-1959.2019.12.022]
 DONG Xian-yan,GAO Li-hua.Clinical Analysis of BNP and NT-proBN in the Diagnosis of Patent Ductus Arteriosus in Premature Infants[J].Journal of Medical Information,2019,32(03):70.[doi:10.3969/j.issn.1006-1959.2019.12.022]
[9]宣恒报,成玉春,杨士军.医院感染的耐药菌分布特点与药物应用[J].医学信息,2019,32(22):114.[doi:10.3969/j.issn.1006-1959.2019.22.037]
 XUAN Heng-bao,CHENG Yu-chun,YANG Shi-jun.Distribution Characteristics and Drug Application of Drug-resistant Bacteria in Nosocomial Infection[J].Journal of Medical Information,2019,32(03):114.[doi:10.3969/j.issn.1006-1959.2019.22.037]
[10]龙小红.枸橼酸咖啡因对早产儿原发性呼吸暂停及相关并发症的影响[J].医学信息,2019,32(22):130.[doi:10.3969/j.issn.1006-1959.2019.22.043]
 LONG Xiao-hong.Effect of Caffeine Citrate on Primary Apnea and Related Complications in Premature Infants[J].Journal of Medical Information,2019,32(03):130.[doi:10.3969/j.issn.1006-1959.2019.22.043]

更新日期/Last Update: 1900-01-01