参考文献/References:
[1]Chen Z,Fillmore CM,Hammerman PS,et al.Non-small-cell lung cancers: a heterogeneous set of diseases[J].Nat Rev Cancer,2014,14(8):535-546.[2]Inamura K.Lung Cancer: Understanding Its Molecular Pathology and the 2015 WHO Classification[J].Front Oncol,2017,7:193.[3]Oberndorfer F,Müllauer L.Molecular pathology of lung cancer: current status and perspectives[J].Curr Opin Oncol,2018,30(2):69-76.[4]Ruiz-Cordero R,Devine WP.Targeted Therapy and Checkpoint Immunotherapy in Lung Cancer[J].Surg Pathol Clin,2020,13(1):17-33.[5]Zhang DD.Mechanistic studies of the NRF2-Keap1 signaling pathway[J].Drug Metab Rev,2006,38(4):769-789.[6]Hammad A,Namani A,Elshaer M,et al."NRF2 addiction" in lung cancer cells and its impact on cancer therapy[J].Cancer Lett,2019,467:40-49.[7]Wilusz JE,Sunwoo H,Spector DL.Long noncoding RNAs: functional surprises from the RNA world[J].Genes Dev,2009,23(13):1494-1504.[8]Wang Z,Song L,Ye Y,et al.Long Noncoding RNA DIO3OS Hinders Cell Malignant Behaviors of Hepatocellular Carcinoma Cells Through the microRNA-328/Hhip Axis[J].Cancer Manag Res,2020,12:3903-3914.[9]Lee JH,Khor TO,Shu L,et al.Dietary phytochemicals and cancer prevention: NRF2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression[J].Pharmacol Ther,2013,137(2):153-171.[10]Kwak MK,Kensler TW.Targeting NRF2 signaling for cancer chemoprevention[J].Toxicol Appl Pharmacol,2010,244(1):66-76.[11]Yamamoto M,Kensler TW,Motohashi H.The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis[J].Physiol Rev,2018,98(3):1169-1203.[12]Iyer MK,Niknafs YS,Malik R,et al.The landscape of long noncoding RNAs in the human transcriptome[J].Nat Genet,2015,47(3):199-208.[13]Kensler TW,Wakabayashi N.NRF2: friend or foe for chemoprevention?[J].Carcinogenesis,2010,31(1):90-99.[14]Zeng Z,Wang ZY,Li YK,et al.Nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) in non-small cell lung cancer[J].Life Sci,2020,254:117325.[15]Rangasamy T,Cho CY,Thimmulappa RK,et al.Genetic ablation of NRF2 enhances susceptibility to cigarette smoke-induced emphysema in mice[J].J Clin Invest,2004,114(9):1248-1259.[16]Cho HY,Reddy SP,Debiase A,et al.Gene expression profiling of NRF2-mediated protection against oxidative injury[J].Free Radic Biol Med,2005,38(3):325-343.[17]Cho HY,Imani F,Miller-DeGraff L,et al.Antiviral activity of NRF2 in a murine model of respiratory syncytial virus disease[J].Am J Respir Crit Care Med,2009,179(2):138-150.[18]Luo P,Wu S,Ji K,et al.LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating NRF2 and HO-1[J].PLoS One,2020,15(11):e0223035.[19]Zhang L,Xu X,Su X.Noncoding RNAs in cancer immunity: functions, regulatory mechanisms, and clinical application[J].Mol Cancer,2020,19(1):48.[20]Zhang G,Lan Y,Xie A,et al.Comprehensive analysis of long noncoding RNA (lncRNA)-chromatin interactions reveals lncRNA functions dependent on binding diverse regulatory elements[J].J Biol Chem,2019,294(43):15613-15622.[21]Ponjavic J,Ponting CP,Lunter G.Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs[J].Genome Res,2007,17(5):556-565.[22]Hombach S,Kretz M.Non-coding RNAs:Classification, Biology and Functioning[J].Adv Exp Med Biol,2016,937:3-17.[23]Chikara S,Nagaprashantha LD,Singhal J,et al.Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment[J].Cancer Lett,2018,413:122-134.[24]Bhattacharjee S,Li J,Dashwood RH.Emerging crosstalk between long non-coding RNAs and NRF2 signaling[J].Cancer Lett,2020,490:154-164.[25]Kim D,Pertea G,Trapnell C,et al.TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions[J].Genome Biol,2013,14(4):R36.[26]Robinson MD,McCarthy DJ,Smyth GK.edgeR: a Bioconductor package for differential expression analysis of digital gene expression data[J].Bioinformatics,2010,26(1):139-140.[27]Liu Y,Sun Y,Li Y,et al.Analyses of Long Non-Coding RNA and mRNA profiling using RNA sequencing in chicken testis with extreme sperm motility[J].Sci Rep,2017,7(1):9055.[28]Trapnell C,Roberts A,Goff L,et al.Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks[J].Nat Protoc,2012,7(3):562-578.[29]Xie C,Mao X,Huang J,et al.KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases[J].Nucleic Acids Res,2011,39(Web Server issue):W316-W322.[30]Ye R,Tang R,Gan S,et al.New insights into long non-coding RNAs in non-small cell lung cancer[J].Biomed Pharmacother,2020,131:110775.[31]Yoshimizu T,Miroglio A,Ripoche MA,et al.The H19 locus acts in vivo as a tumor suppressor[J].Proc Natl Acad Sci U S A,2008,105(34):12417-12422.[32]Kim K,Jutooru I,Chadalapaka G,et al.HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer[J].Oncogene,2013,32(13):1616-1625.[33]Zhou Y,Zhang X,Klibanski A.MEG3 noncoding RNA: a tumor suppressor[J].J Mol Endocrinol,2012,48(3):R45-R53.[34]Sekine H,Motohashi H.Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer[J].Cancers (Basel),2021,13(3):541.[35]Rojo de la Vega M,Chapman E,Zhang DD.NRF2 and the Hallmarks of Cancer[J].Cancer Cell,2018,34(1):21-43.[36]Menegon S,Columbano A,Giordano S.The Dual Roles of NRF2 in Cancer[J].Trends Mol Med,2016,22(7):578-593.[37]Taguchi K,Motohashi H,Yamamoto M.Molecular mechanisms of the Keap1-NRF2 pathway in stress response and cancer evolution[J].Genes Cells,2011,16(2):123-140.[38]Fernandes JCR,Acuna SM,Aoki JI,et al.Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease[J].Noncoding RNA,2019,5(1):17.[39]Wu S,Lu H,Bai Y.NRF2 in cancers: A double-edged sword[J].Cancer Med,2019,8(5):2252-2267.[40]Fabrizio FP,Sparaneo A,Trombetta D,et al.Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs[J].Oxid Med Cell Longev,2018,2018:2492063.[41]Cloer EW,Goldfarb D,Schrank TP,et al.NRF2 Activation in Cancer: From DNA to Protein[J].Cancer Res,2019,79(5):889-898.[42]Yang G,Yin H,Lin F,et al.Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the NRF2 signaling axis[J].Pathol Res Pract,2020,216(4):152851.[43]Thai P,Statt S,Chen CH,et al.Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines[J].Am J Respir Cell Mol Biol,2013,49(2):204-211.[44]Moreno Leon L,Gautier M,Allan R,et al.The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress[J].Oncogene,2019,38(46):7146-7165.[45]Hayes JD,McMahon M,Chowdhry S,et al.Cancer chemoprevention mechanisms mediated through the Keap1-NRF2 pathway[J].Antioxid Redox Signal,2010,13(11):1713-1748.[46]Kong Q,Deng H,Li C,et al.Sustained high expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells[J].Sci Total Environ,2021,756:143840.[47]Xie F,Li L,Luo Y,et al.Long non-coding RNA LINC00488 facilitates thyroid cancer cell progression through miR-376a-3p/PON2[J].Biosci Rep,2021,41(3):BSR20201603.[48]Xu H,Ye Y.LINC00488 stimulates the progression of esophageal cancer by targeting microRNA-485-5p[J].Oncol Lett,2021,21(2):86.