[1]李晓靖,周永明,李 洋,等.外周血NK细胞与原发免疫性血小板减少症相关性的Meta分析[J].医学信息,2024,37(01):72-77.[doi:10.3969/j.issn.1006-1959.2024.01.013]
　LI Xiao-jing,ZHOU Yong-ming,LI Yang,et al.Meta-analysis of the Correlation Between Peripheral Blood NK Cells and Primary Immune Thrombocytopenia[J].Journal of Medical Information,2024,37(01):72-77.[doi:10.3969/j.issn.1006-1959.2024.01.013]
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外周血NK细胞与原发免疫性血小板减少症相关性的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年01期
页码:
72-77
栏目:
医学数据科学
出版日期:
2024-01-01

文章信息/Info

Title:
Meta-analysis of the Correlation Between Peripheral Blood NK Cells and Primary Immune Thrombocytopenia
文章编号:
1006-1959（2024）01-0072-06
作者:
李晓靖; 周永明; 李 洋; 等
（上海中医药大学附属岳阳中西医结合医院血液科，上海 200437）
Author(s):
LI Xiao-jing; ZHOU Yong-ming; LI Yang; et al.
(Department of Hematology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
关键词:
NK细胞; 原发免疫性血小板减少症; 免疫耐受
Keywords:
NK cell; Primary immune thrombocytopenia; Immune tolerance
分类号:
R593.2
DOI:
10.3969/j.issn.1006-1959.2024.01.013
文献标志码:
A
摘要:
目的 系统评价外周血自然杀伤（NK）细胞与原发免疫性血小板减少症（ITP）的相关性。方法 全面检索PubMed、Springer Link、OVID、中国期刊全文数据库（CNKI）、维普中文科技期刊全文数据库（VIP）、中国生物医学文献服务系统（Sino Med）、万方医药期刊数据库（WAN FANG）等，查找关于NK细胞与ITP相关的研究，利用ReviewManager 5.3软件对纳入的研究进行Meta分析。结果 最终纳入7项病例对照研究，共有514例研究对象，其中ITP组302例，对照组212例。Meta分析结果显示外周血NK细胞水平与ITP之间有显著的相关性（MD=-5.58，95%CI：-8.00~-3.15，P＜0.000 01）；亚群分析结果显示外周血NK细胞水平与新诊断ITP存在明显相关性（MD=-4.89，95%CI：-9.39~-0.39，P=0.03）。结论 外周血NK细胞水平与ITP之间有显著的相关性，靶向异常的NK细胞可能对ITP的发生、发展具有影响，为其治疗方案提供了理论基础。
Abstract:
Objective To systematically evaluate the correlation between peripheral blood natural killer (NK) cells and primary immune thrombocytopenia (ITP).Methods Pub Med, Springer Link, OVID, China national knowledge infrastructure (CNKI), VIP Chinese Sci-tech Periodicals (VIP), China Biomedical Literature Service System (Sino Med), Wanfang Medical Periodicals (WAN FANG) were searched comprehensively to find the studies on the relationship between NK cells and ITP. Meta-analysis was performed on the included studies using Review Manager 5.3 software.Results Finally, 7 case-control studies were included, with a total of 514 subjects, including 302 in the ITP group and 212 in the control group. The results of Meta-analysis showed that there was a significant correlation between peripheral blood NK cell level and ITP (MD=-5.58,95%CI:-8.00 to -3.15, P<0.000 01). The results of subgroup analysis showed that the level of NK cells in peripheral blood was significantly correlated with the newly diagnosed ITP (MD=-4.89,95%CI:-9.39 to -0.39,P=0.03).Conclusion There is a significant correlation between peripheral blood NK cell level and ITP. Targeted abnormal NK cells may have an impact on the occurrence and development of ITP, which provides a theoretical basis for its treatment plan.

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更新日期/Last Update: 1900-01-01