[1]龙 颖,李运泽,汤中敏,等.非酒精性脂肪性肝病与血尿酸水平测定及其临床意义[J].医学信息,2018,31(07):92-94.[doi:10.3969/j.issn.1006-1959.2018.07.029]
　LONG Ying,LI Yun-ze,TANG Zhong-min,et al.Determination of Serum Uric Acid Level and its Clinical Significance in Non-alcoholic Fatty Liver Disease[J].Journal of Medical Information,2018,31(07):92-94.[doi:10.3969/j.issn.1006-1959.2018.07.029]
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非酒精性脂肪性肝病与血尿酸水平测定及其临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年07期
页码:
92-94
栏目:
论著
出版日期:
2018-04-01

文章信息/Info

Title:
Determination of Serum Uric Acid Level and its Clinical Significance in Non-alcoholic Fatty Liver Disease
文章编号:
1006-1959（2018）07-0092-03
作者:
龙 颖; 李运泽; 汤中敏; 陈丽婷
柳州市人民医院消化科，广西 柳州 545006
Author(s):
LONG Ying; LI Yun-ze; TANG Zhong-min; CHEN Li-ting
Department of Digestive Diseases,Liuzhou People's Hospital,Liuzhou 545006,Guangxi,China
关键词:
非酒精性脂肪性肝病; 尿酸; 肥胖; 代谢综合征
Keywords:
Key words：Non-alcoholic fatty liver disease; Uric acid; Obesity; Metabolic syndrome
分类号:
R575.5
DOI:
10.3969/j.issn.1006-1959.2018.07.029
文献标志码:
A
摘要:
目的 探讨非酒精性脂肪性肝病（NAFLD）与血尿酸水平的关系。方法 选取在我院常规体检的2666例成人，其中经腹部彩超诊断为脂肪肝者为NAFLD组共603例，无脂肪肝者为非NAFLD组共2063例。根据BMI将其分为肥胖组290例及非肥胖组2376例。回顾性分析研究对象的年龄、血压、UA、FBG、TC、TG、LDL、GDL等临床指标。结果 NAFLD组的年龄、收缩压、舒张压、UA、FBG、TC、TG、LDL均高于非NAFLD组，差异具有统计学意义（P＜0.05）；而NAFLD组的HDL水平低于非NAFLD组，差异具有统计学意义（P＜0.05）。肥胖组的年龄、收缩压、舒张压、UA、FBG、TC、TG、LDL均高于非肥胖组，差异具有统计学意义（P＜0.05）；而肥胖组的HDL水平低于非肥胖组，差异具有统计学意义（P＜0.05）。在肥胖组中，血尿酸水平与是否发生NAFLD无明显相关关系（r=0.095，P=0.107），而在非肥胖组中，血尿酸水平与是否发生NAFLD呈正相关关系（r=0.229，P=0.000）。结论 在非肥胖人群中，高尿酸血症可作为NAFLD的独立危险因素，为临床上NAFLD的治疗提供一定的实用价值。
Abstract:
Abstract：Objective To investigate the relationship between non-alcoholic fatty liver disease(NAFLD)and serum uric acid levels.Methods A total of 2666 adults who received routine physical examination in our hospital were selected.Among them,603 cases were diagnosed as fatty liver by transabdominal color Doppler ultrasound.There were 603 cases in group NAFLD,and 2063 cases without fatty liver in non NAFLD group.According to BMI,it was divided into 290 cases of obesity group and 2376 cases of non obese group. Retrospective analysis of the age,blood pressure,UA,FBG,TC,TG,LDL,GDL and other clinical indicators.Results The age,systolic blood pressure,diastolic blood pressure,UA,FBG,TC,TG,and LDL in the NAFLD group were higher than those in the non-NAFLD group,the difference was statistically significant(P<0.05),while the HDL levels in the NAFLD group were lower than those in the non-NAFLD group,the difference was statistically significant(P<0.05).The age,systolic blood pressure,diastolic blood pressure,UA,FBG,TC, TG,and LDL in the obese group were higher than those in the non-obese group,the difference was statistically significant(P<0.05), while the HDL level in the obese group was lower than that in the non-obese group,the difference was statistically significant(P<0.05). In the obese group,there was no significant correlation between serum uric acid level and NAFLD(r=0.095,P=0.107).In non-obese group,serum uric acid level was positively correlated with NAFLD(r=0.229,P=0.000).Conclusion Hyperuricemia can be used as an independent risk factor of NAFLD in non-obese people,which provides a practical value for clinical treatment of NAFLD.

参考文献/References:

[1]Masarone M,Federico A,Abenavoli L,et al.Non alcoholic fatty liver:epidemiology and natural history[J].Reviews on Recent Clinical Trials,2014,9(3):126. [2]Wang FS,Fan JG,Zhang Z,et al.The global burden of liver disease:the major impact of China[J].Hepatology,2014,60(6):2099. [3]Wijarnpreecha K,Panjawatanan P,Lekuthai N,et al.Hyperuricemia and Risk of Nonalcoholic Fatty Liver Disease:A Meta-analysis[J].Liver International Official Journal of the International Association for the Study of the Liver,2016,37(6):906-918. [4]中华医学会肝病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南(2010年修订版)[J].中华肝脏病杂志,2010,18(3):163-166. [5]Qiang S,Nakatsu Y,Seno Y,et al.Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus[J].Diabetology&Metabolic Syndrome,2015,7(1):104. [6]Fan J,Saibara T,Chitturi S,et al.What are the risk factors and settings for non‐alcoholic fatty liver disease in Asia-Pacific[J].Journal of Gastroenterology&Hepatology,2007,22(6):794-800. [7]Ho KT,Su LS,Han YJ,et al.The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus[J].Diabetology &Metabolic Syndrome,2012,4(1):1-7. [8]Lombardi R,Pisano G,Fargion S.Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD[J].International Journal of Molecular Sciences,2016,17(4):548. [9]Chao Y,Yang S,Xu W,et al.Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population:A retrospective cohort study[J].Plos One,2017,12(5):e0177249. [10]Goicoechea M,Garciad VS,Verdalles U,et al.Allopurinol and progression of CKD and cardiovascular events:long-term follow-up of a randomized clinical trial[J].American Journal of Kidney Diseases,2015,65(4):543-549.

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更新日期/Last Update: 2018-04-01