[1]钱熠辉,彭 琼.乙型肝炎病毒感染与结直肠腺瘤的相关性研究[J].医学信息,2019,32(04):81-84.[doi:10.3969/j.issn.1006-1959.2019.04.027]
　QIAN Yi-hui,PENG Qiong.Correlation between Hepatitis B Virus Infection and Colorectal Adenoma[J].Journal of Medical Information,2019,32(04):81-84.[doi:10.3969/j.issn.1006-1959.2019.04.027]
点击复制

乙型肝炎病毒感染与结直肠腺瘤的相关性研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年04期
页码:
81-84
栏目:
论著
出版日期:
2019-02-15

文章信息/Info

Title:
Correlation between Hepatitis B Virus Infection and Colorectal Adenoma
文章编号:
1006-1959（2019）04-0081-04
作者:
钱熠辉; 彭 琼
（安徽医科大学第三附属医院消化内科，安徽 合肥 230000）
Author(s):
QIAN Yi-hui; PENG Qiong
(Department of Gastroenterology,the Third Affiliated Hospital of Anhui Medical University, Hefei 230000,Anhui,China)
关键词:
乙型肝炎病毒; 结直肠腺瘤; HBV-DNA; 肠道微物群
Keywords:
Hepatitis B virus; Colorectal adenoma; HBV-DNA; Intestinal micro-organisms
分类号:
R735.3
DOI:
10.3969/j.issn.1006-1959.2019.04.027
文献标志码:
A
摘要:
目的 探讨乙型肝炎病毒（HBV）感染对结直肠腺瘤发生发展的影响。方法 选取2016年1月~2018年1月于我院接受筛查或诊断性结肠镜检查符合入组标准的506例患者进行回顾性病历对照研究。按照乙肝五项定量结果分为非HBV感染组及HBV感染组，感染组人员依据HBV-DNA结果进一步分为HBV-DNA阳性组与HBV-DNA阴性组，比较乙型肝炎病毒感染不同状态与非感染者腺瘤发生率之间的差异及HBV活动对腺瘤发生部位，大小等的影响。结果 ①HBV感染组和非HBV感染组在年龄、性别、吸烟史、饮酒史、高血压史、糖尿病史、胆囊切除史、药物服用史等方面比较，差异均无统计学意义（P＞0.05）；②HBV-DNA阳性组腺瘤发病率高于非HBV感染组（37.10% vs 24.16%）差异有统计学意义（P＜0.05）；③HBV-DNA阳性组远端结肠腺瘤性息肉、腺瘤数目≥2个的发病率高于非HBV感染组（24.19% vs 12.47%），差异均有统计学意义（P＜0.05），HBV-DNA阳性组进展期腺瘤、＞10 mm及近端结肠腺瘤性息肉腺瘤发病率高于非HBV感染组，但差异无无统计学意义（P＞0.05）。结论 HBV感染患者远端结肠腺瘤发病率升高且全肠段易多发腺瘤，对于各类型慢性乙型肝炎患者或反复乙型肝炎再活动者应采取与普通人不同的结直肠腺瘤筛查及预防策略。
Abstract:
Objective To investigate the effect of hepatitis B virus (HBV) infection on the development of colorectal adenoma.Methods A retrospective medical history study was performed on 506 patients who underwent screening or diagnostic colonoscopy in our hospital from January 2016 to January 2018. According to the five quantitative results of hepatitis B, the patients were divided into non-HBV infection group and HBV infection group. The infection group was further divided into HBV-DNA positive group and HBV-DNA negative group according to HBV-DNA results, comparing different states of hepatitis B virus infection. The difference between the incidence of adenomas in infected patients and the influence of HBV activity on the location and size of adenomas. Results ①There were no significant differences in age, gender, smoking history, drinking history, history of hypertension, history of diabetes, history of cholecystectomy, and history of drug use between the 1HBV-infected group and the non-HBV-infected group (P>0.05);②The incidence of adenoma in HBV-DNA positive group was higher than that in non-HBV infection group (37.10% vs 24.16%)the difference was statistically significant (P<0.05);③The incidence of distal colon adenomatous polyps and adenomas ≥2 in HBV-DNA positive group was higher than that in non-HBV infection group (24.19% vs 12.47%), the difference was statistically significant (P<0.05),The incidence of advanced adenoma, >10 mm and proximal colon adenomatous polyposis in HBV-DNA positive group was higher than that in non-HBV infection group, but the difference was not statistically significant (P>0.05). Conclusion Patients with HBV infection have an increased incidence of distal colon adenomas and multiple adenomas in the entire intestine. For patients with various types of chronic hepatitis B or repeated hepatitis B re-activity, screening for colorectal adenomas should be performed differently from ordinary people and prevention strategies.

参考文献/References:


[1]Schweitzer A,Horn J,Mikolajczyk RT,et al.Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013[J].Lancet,2015,386(10003):1546-1555.
[2]段瑞波,刘立新.1992-2016年我国乙型肝炎病毒携带率变化特点的Meta分析[J].中华消化病与影像杂志(电子版),2018(3):116-126.
[3]Kamiza AB,Su FH,Wang WC,et al.Chronic hepatitis infection is associated with extrahepatic cancer development: a nationwide population-based study in Taiwan[J].BMC Cancer,2016,16(1):861.
[4]Dumitrascu T,Pineau P.Is Hepatitis B Virus a Player in Pancreatic Cancer?[J].Chirurgia(Bucur),2018,113(3):344-352.
[5]Sundquist K,Sundquist J,Ji J.Risk of hepatocellular carcinoma and cancers at other sites among patients diagnosed with chronic hepatitis B virus infection in Sweden[J].J Med Virol,2014,86(1):18-22.
[6]Patel BB,Lipka S,Shen H,et al.Establishing the link between hepatitis B virus infection and colorectal adenoma[J].J Gastrointest Oncol,2015,6(5):492-497.
[7]Zheng JS,Chen MM,Yang HF,et al.Stool vs. Serum Hepatitis B Virus DNA in Patients with Chronic Hepatitis B[J].Med Sci Monit,2015(21):3840-3846.
[8]Kim SH,Kim JW,Lee KL,et al.Hepatitis B Virus Infection Is Independently Associated With Advanced Colorectal Adenoma[J].Am J Med Sci,2018,356(2):141-146.
[9]Choi JH,Jeong H,Jang KL.Hepatitis B virus X protein suppresses all-trans retinoic acid-induced apoptosis in human hepatocytes by repressing p14 expression via DNA methylation[J].J Gen Virol,2017,98(11):2786-2798.
[10]Li XL,Zhou J,Chen ZR,et al.P53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivation[J].World J Gastroenterol,2015,21(1):84-93.
[11]Wang J,Wang Y,Zhang X,et al.Gut Microbial Dysbiosis Is Associated with Altered Hepatic Functions and Serum Metabolites in Chronic Hepatitis B Patients[J].Front Microbiol,2017(8):2222.
[12]Chassaing B,Etienne-Mesmin L,Gewirtz AT.Microbiota-liver axis in hepatic disease[J].Hepatology,2014,59(1):328-339.
[13]Keku TO,Mccoy AN,Azcarate-Peril AM.Fusobacterium spp. and colorectal cancer: cause or consequence?[J].Trends Microbiol,2013,21(10):506-508.

相似文献/References:

[1]杨美玲,黄荷凤.HBV暴露对子代影响的研究进展[J].医学信息,2019,32(10):32.[doi:10.3969/j.issn.1006-1959.2019.10.012]
　YANG Mei-ling,HUANG He-feng.Advances in Research on the Effects of HBV Exposure on Offspring[J].Journal of Medical Information,2019,32(04):32.[doi:10.3969/j.issn.1006-1959.2019.10.012]
[2]马艳会,寇 毅.幽门螺杆菌感染与结直肠腺瘤临床特征的相关性研究[J].医学信息,2022,35(16):102.[doi:10.3969/j.issn.1006-1959.2022.16.024]
　MA Yan-hui,KOU Yi.Correlation Between Helicobacter Pylori Infection and Clinical Features of Colorectal Adenoma[J].Journal of Medical Information,2022,35(04):102.[doi:10.3969/j.issn.1006-1959.2022.16.024]
[3]唐细田,肖 琳,徐彤慧.化学发光法和酶联免疫法在乙型肝炎病毒血清学检验中的效果比较[J].医学信息,2019,32(22):164.[doi:10.3969/j.issn.1006-1959.2019.22.057]
　TANG Xi-tian,XIAO Lin,XU Tong-hui.Comparison of the Effects of Chemiluminescence and Enzyme-linked Immunosorbent Assay on Serological Test of Hepatitis B Virus[J].Journal of Medical Information,2019,32(04):164.[doi:10.3969/j.issn.1006-1959.2019.22.057]
[4]苏振华.乙肝病毒标记物阳性表型血清标本乙型肝炎病毒HBV-DNA临床检验分析[J].医学信息,2020,33(04):179.[doi:10.3969/j.issn.1006-1959.2020.04.061]
　SU Zhen-hua.Clinical Analysis of Hepatitis B Virus HBV-DNA in Serum Specimen with Hepatitis B Virus Markers Positive[J].Journal of Medical Information,2020,33(04):179.[doi:10.3969/j.issn.1006-1959.2020.04.061]
[5]党便利,孙永涛,康文臻.HBcrAg在慢性乙型肝炎中研究进展[J].医学信息,2020,33(17):23.[doi:10.3969/j.issn.1006-1959.2020.17.007]
　DANG Bian-li,SUN Yong-tao,KANG Wen-zhen.Research Progress of HBcrAg in Chronic Hepatitis B[J].Journal of Medical Information,2020,33(04):23.[doi:10.3969/j.issn.1006-1959.2020.17.007]
[6]文 静.HBV感染患者血清25（OH）D3含量与HBV DNA载量的相关性[J].医学信息,2022,35(21):81.[doi:10.3969/j.issn.1006-1959.2022.21.018]
　WEN Jing.Correlation Between Serum 25(OH)D3 Content and HBV DNA Load in Patients with HBV Infection[J].Journal of Medical Information,2022,35(04):81.[doi:10.3969/j.issn.1006-1959.2022.21.018]
[7]帅苍南,张玉亭,刘 敏,等.抗慢性乙型肝炎肝纤维化中成药研究进展[J].医学信息,2022,35(08):38.[doi:10.3969/j.issn.1006-1959.2022.08.010]
　SHUAI Cang-nan,ZHANG Yu-ting,LIU Min,et al.Research Progress of Anti-chronic Hepatitis B Liver Fibrosis Chinese Patent Medicine[J].Journal of Medical Information,2022,35(04):38.[doi:10.3969/j.issn.1006-1959.2022.08.010]
[8]余呈丽,李瑞娟.无偿献血人群血液筛查后乙型肝炎病毒传播的残余风险评估[J].医学信息,2024,37(13):49.[doi:10.3969/j.issn.1006-1959.2024.13.009]
　Residual Risk Assessment of Hepatitis B Virus Transmission After Blood Screening in Voluntary Blood Donors.Residual Risk Assessment of Hepatitis B Virus Transmission After Blood Screening in Voluntary Blood Donors[J].Journal of Medical Information,2024,37(04):49.[doi:10.3969/j.issn.1006-1959.2024.13.009]
[9]章勇军.乙肝两对半和DNA联合检验在乙肝诊断中的价值[J].医学信息,2024,37(21):169.[doi:10.3969/j.issn.1006-1959.2024.21.040]
　ZHANG Yongjun.Value of Combined Detection of HBV Antigen, Antibody and DNA in the Diagnosis of Hepatitis B[J].Journal of Medical Information,2024,37(04):169.[doi:10.3969/j.issn.1006-1959.2024.21.040]

更新日期/Last Update: 2019-03-07