[1]张天竺,宁 勇.长链非编码RNA调控乳腺癌发生发展的研究进展[J].医学信息,2019,32(12):40-45.[doi:10.3969/j.issn.1006-1959.2019.12.014]
 ZHANG Tian-zhu,NING Yong.Advances in Research on Long-chain Non-coding RNA Regulation of Breast Cancer Development[J].Journal of Medical Information,2019,32(12):40-45.[doi:10.3969/j.issn.1006-1959.2019.12.014]
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长链非编码RNA调控乳腺癌发生发展的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年12期
页码:
40-45
栏目:
综述
出版日期:
2019-06-15

文章信息/Info

Title:
Advances in Research on Long-chain Non-coding RNA Regulation of Breast Cancer Development
文章编号:
1006-1959(2019)12-0040-06
作者:
张天竺宁 勇
湖北中医药大学,湖北 武汉 430065
Author(s):
ZHANG Tian-zhuNING Yong
Hubei University of Traditional Chinese Medicine,Wuhan 430065,Hubei,China
关键词:
长链非编码RNA乳腺癌分子机制细胞增殖侵袭转移凋亡
Keywords:
Key words:Long-chain non-coding RNABreast cancerMolecular mechanismCell proliferation InvasionMetastasisApoptosis
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2019.12.014
文献标志码:
A
摘要:
乳腺癌是女性最常见的疾病之一,由于本身的复杂性和异质性,使其仍然是公共卫生领域的一大难题。近几年来随着技术的发展,长链非编码RNA(lncRNA)受到了广泛的关注。大量研究表明,长链非编码RNA由于其关键的生物调控功能,在肿瘤的发生、发展中发挥着重要作用。尽管长链非编码RNA的具体分子机制尚未完全明确,但最近的研究表明,许多长链非编码RNA在多种肿瘤中表达异常,其中包括乳腺癌。本文主要对长链非编码RNA与乳腺癌的最新研究进行了综述,并进一步探索长链非编码RNA在影响乳腺癌增殖、凋亡、侵袭、转移中的分子机制。
Abstract:
Abstract:Breast cancer is one of the most common diseases in women. Due to its complexity and heterogeneity, it is still a major problem in the field of public health. In recent years, with the development of technology, long-chain non-coding RNA (lncRNA) has received extensive attention. A large number of studies have shown that long-chain non-coding RNA plays an important role in the occurrence and development of tumors due to its key biological regulatory functions. Although the specific molecular mechanisms of long-chain non-coding RNA are not fully understood, recent studies have shown that many long-chain non-coding RNAs are abnormally expressed in a variety of tumors, including breast cancer. This article reviews the recent research on long-chain non-coding RNA and breast cancer, and further explores the molecular mechanism of long-chain non-coding RNA in affecting breast cancer proliferation, apoptosis, invasion and metastasis.

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更新日期/Last Update: 2019-06-15