[1]钟达媚,张 颖.PCG与卵巢癌关系的研究[J].医学信息,2020,33(01):28-31.[doi:10.3969/j.issn.1006-1959.2020.01.011]
 ZHONG Da-mei,ZHANG Ying.Study on the Relationship Between PCG and Ovarian Cancer[J].Medical Information,2020,33(01):28-31.[doi:10.3969/j.issn.1006-1959.2020.01.011]
点击复制

PCG与卵巢癌关系的研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年01期
页码:
28-31
栏目:
综述
出版日期:
2020-01-01

文章信息/Info

Title:
Study on the Relationship Between PCG and Ovarian Cancer
文章编号:
1006-1959(2020)01-0028-04
作者:
钟达媚12张 颖2
(1.广东医科大学,广东 湛江 524000;2.广东医科大学附属医院妇科,广东 湛江 524000)
Author(s):
ZHONG Da-mei12ZHANG Ying2
(1.Guangdong Medical University,Zhanjiang 524000,Guangdong,China;2.Department of Gynecology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,China)
关键词:
PCG卵巢癌沉默因子
Keywords:
PCGOvarian cancerSilencing factor
分类号:
R737.31
DOI:
10.3969/j.issn.1006-1959.2020.01.011
文献标志码:
A
摘要:
卵巢癌是女性生殖系统最常见的恶性肿瘤之一,具有早期难以诊断、晚期生存率低及预后差的特点。因此,在临床上迫切需要寻找一种新的靶向标志物,以优化当前卵巢癌的诊疗。除癌基因及抑癌基因突变引起肿瘤外,表观遗传变化也参与肿瘤的发生发展。PCG蛋白作为表观遗传相关基因的沉默因子,与肿瘤的发生发展密切相关。本文就PCG的组成及其与肿瘤的关系、PCG关键亚基的结构及其与卵巢癌的关系作一综述,以期为临床治疗提供参考依据。
Abstract:
Ovarian cancer is one of the most common malignant tumors in the female reproductive system. It is difficult to diagnose early, has low survival rates, and has a poor prognosis. Therefore, it is urgently needed to find a new targeting marker in clinic to optimize the current diagnosis and treatment of ovarian cancer. In addition to tumors caused by mutations of oncogenes and tumor suppressor genes, epigenetic changes are also involved in the development of tumors. As a silencing factor of epigenetic related genes, PCG protein is closely related to tumorigenesis and development. This article reviews the composition of PCG and its relationship with tumors, the structure of key PCG subunits, and its relationship with ovarian cancer, with a view to providing reference for clinical treatment.

参考文献/References:

[1]Zheng B,Shen H,Han H,et al.Dietary fiber intake and reduced risk of ovarian cancer:a meta-analysis[J].Nutr J,2018,17(1):99. [2]Kathawala RJ,Kudelka A,Rigas B.The Chemoprevention of Ovarian Cancer:the Need and the Options[J].Current Pharmacology Reports,2018,4(3):250-260. [3]Markowska A,Sajdak S,Huczyński A,et al.Ovarian cancer stem cells:A target for oncological therapy[J].Adv Clin Exp Med,2018,27(7):1017-1020. [4]Lupia M,Cavallaro U.Ovarian cancer stem cells:still an elusive entity[J].Mol Cancer,2017,16(1):64. [5]Chan HL,Morey L.Emerging Roles for Polycomb-Group Proteins in Stem Cells and Cancer[J].Trends Biochem Sci,2019,44(8):688-700. [6]Di Carlo V,Mocavini I,Di Croce L.Polycomb complexes in normal and malignant hematopoiesis[J].The Journal of Cell Biology,2019,218(1):55-69. [7]Kouznetsova VL,Tchekanov A,Li X,et al.Polycomb repressive 2 complex-Molecular mechanisms of function[J].Protein Sci,2019,28(8):1387-1399. [8]Brand M,Nakka K,Zhu J,et al.Polycomb/Trithorax Antagonism:Cellular Memory in Stem Cell Fate and Function[J].Cell Stem Cell,2019,24(4):518-533. [9]Sahasrabuddhe AA.BMI1:A Biomarker of Hematologic Malignancies[J].Biomark Cancer,2016(8):65-75. [10]Gray F,Cho HJ,Shukla S,et al.BMI1 regulates PRC1 architecture and activity through homo-and hetero-oligomerization[J].Nat Commun,2016(7):13343. [11]Bhattacharya R,Banerjee Mustafi S,Street M,et al.Bmi-1:At the crossroads of physiological and pathological biology[J].Genes&Diseases,2015,2(3):225-239. [12]Storti B,Civita S,Faraci P,et al.Fluorescence imaging of biochemical relationship between ubiquitinated histone 2A and Polycomb complex protein BMI1[J].Biophys Chem,2019(253):106225. [13]Abd El Hafez A,El-Hadaad HA.Immunohistochemical expression and prognostic relevance of Bmi-1,a stem cell factor,in epithelial ovarian cancer[J].Ann Diagn Pathol,2014,18(2):58-62. [14]Wang JL,Wu JH,CH.Involvement of Bmi-1 gene in the development of gastrointestinal stromal tumor by regulating p16Ink4A/p14ARF gene expressions:An in vivo and in vitro study[J].Pathol Res Pract,2017,213(12):1542-1551. [15]Yang G,He W,Cai M,et al.Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma[J].BMC Cancer,2010,10(1):133. [16]Kim BR,Kwon Y,Rho SB.BMI-1 interacts with sMEK1 and inactivates sMEK1-induced apoptotic cell death[J].Oncol Rep,2017,37(1):579-586. [17]Kim B,Seo SH,Park MS,et al.sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1α signaling pathways[J].Oncotarget,2015,6(31):31380. [18]Takeda Y,Mori T,Imabayashi H,et al.Can the life span of human marrow stromal cells be prolonged by bmi-1,E6,E7,and/or telomerase without affecting cardiomyogenic differentiation[J].The Journal of Gene Medicine,2004,6(8):833-845. [19]Zhang FB,Sui LH,Xin T.Correlation of Bmi-1 expression and telomerase activity in human ovarian cancer[J].Brit J Biomed Sci,2008,65(4):172-177. [20]Zhang XL,Sun BL,Tian SX,et al.MicroRNA-132 reverses cisplatin resistance and metastasis in ovarian cancer by the targeted regulation on Bmi-1[J].Eur Rev Med Pharmacol Sci,2019,23(9):3635-3644. [21]Dey A,Xiong X,Crim A,et al.Evaluating the Mechanism and Therapeutic Potential of PTC-028,a Novel Inhibitor of BMI-1 Function in Ovarian Cancer[J].Mol Cancer Ther,2018,17(1):39-49. [22]吕缜一,陆昌瑞.人源CBX7全长及部分片段的表达纯化及单体结构研究[J].生物化工,2018,4(1):1-4. [23]Federico A,Sepe R,Cozzolino F,et al.The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration[J].Gene Regulatory Mechanisms,2019,1862(4):509-521. [24]关珊丽.多梳蛋白CBX家族成员间的分子互作初步研究[D].兰州大学,2017. [25]廖艳丹,韩庆.CBX7蛋白在卵巢癌组织中的表达及意义[J].重庆医学,2012,41(20):2045-2046. [26]廖艳丹,韩庆.CBX7 mRNA在卵巢癌组织中的表达及意义[J].中国医药导报,2012,9(15):37-38. [27]高尚.CBX7在卵巢浆液性上皮性肿瘤中的表达及意义[D].中国医科大学,2015. [28]Shinjo K,Yamashita Y,Yamamoto E,et al.Expression of chromobox homolog 7(CBX7)is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation[J].Int J Cancer,2014,135(2):308-318. [29]Mu W,Starmer J,Yee D,et al.EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation[J].Epigenet Chromatin,2018,11(1):71. [30]Kim KH,Roberts CWM.Targeting EZH2 in cancer[J].Nat Med,2016,22(2):128-134. [31]Martinez-Canales S,Lopez DRM,Nuncia-Cantarero M,et al.Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer[J].Cancer Med,2018,7(5):1896-1907. [32]Guo J,Cai J,Yu L,et al.EZH2 regulates expression of p57 and contributes to progression of ovarian cancer in vitro and in vivo[J].Cancer Sci,2011,102(3):530-539. [33]Lu F,Xu H,Wang Q,et al.Inhibition of enhancer of zeste homolog 2 increases the expression of p16 and suppresses the proliferation and migration of ovarian carcinoma cells in vitro and in vivo[J].Oncol Lett,2018,15(3):3233-3239. [34]Zeng XY,Jiang XY,Yong JH,et al.lncRNA ABHD11-AS1,regulated by the EGFR pathway,contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2[J].Cancer Med,2019,8(16):7074-7085. [35]Jones BA,Varambally S,Arend RC.Histone Methyltransferase EZH2:A Therapeutic Target for Ovarian Cancer[J].Mol Cancer Ther,2018,17(3):591-602. [36]Yi X,Guo J,Guo J,et al.EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion[J].Sci Rep,2017,7(1):3568. [37]Hu S,Yu L,Li Z,et al.Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo[J].Cancer Biol Ther,2014,10(8):788-795. [38]Sun Y,Jin L,Liu J,et al.Interfering EZH2 Expression Reverses the Cisplatin Resistance in Human Ovarian Cancer by Inhibiting Autophagy[J].Cancer Biother Radio,2016,31(7):246-252.

相似文献/References:

[1]杨廷双.卵巢癌患者经CT检查和MRI检查的临床效果对比[J].医学信息,2018,31(07):153.[doi:10.3969/j.issn.1006-1959.2018.07.053]
 YANG Ting-shuang.Comparison of Clinical Effects between CT and MRI in Patients with Ovarian Cancer[J].Medical Information,2018,31(01):153.[doi:10.3969/j.issn.1006-1959.2018.07.053]
[2]揭嘉慧,张 颖.卵巢癌与非编码RNA研究进展[J].医学信息,2019,32(05):39.[doi:10.3969/j.issn.1006-1959.2019.05.014]
 JIE Jia-hui,ZHANG Ying.Progress in Research on Ovarian Cancer and Non-coding RNA[J].Medical Information,2019,32(01):39.[doi:10.3969/j.issn.1006-1959.2019.05.014]
[3]林斯婕,吴 璇,覃 桓,等.卵巢癌合并2型糖尿病发生的危险因素分析[J].医学信息,2019,32(05):124.[doi:10.3969/j.issn.1006-1959.2019.05.039]
 LIN Si-jie,WU Xuan,QIN Huan,et al.Analysis of Risk Factors for Ovarian Cancer Complicated with Type 2 Diabetes[J].Medical Information,2019,32(01):124.[doi:10.3969/j.issn.1006-1959.2019.05.039]
[4]李思文,张 燕.不同紫杉醇剂型联合卡铂治疗卵巢癌的疗效研究[J].医学信息,2019,32(07):150.[doi:10.3969/j.issn.1006-1959.2019.07.046]
 LI Si-wen,ZHANG Yan.Therapeutic Effect of Different Paclitaxel Dosage Forms Combined With Carboplatin On Ovarian Cancer[J].Medical Information,2019,32(01):150.[doi:10.3969/j.issn.1006-1959.2019.07.046]
[5]许书凡,庞 华.18F-FDGPET/CT在卵巢癌中的应用研究[J].医学信息,2019,32(08):75.[doi:10.3969/j.issn.1006-1959.2019.08.022]
 XU Shu-fan,PANG Hua.Research on the Application of 18F-FDGPET/CT in Ovarian Cancer[J].Medical Information,2019,32(01):75.[doi:10.3969/j.issn.1006-1959.2019.08.022]
[6]张秀芳,陈 萍.安罗替尼联合顺铂治疗晚期卵巢癌恶性腹腔积液的疗效观察[J].医学信息,2019,32(18):132.[doi:10.3969/j.issn.1006-1959.2019.18.044]
 ZHANG Xiu-fang,CHEN Ping.Efficacy of Erlotinib Combined with Cisplatin in the Treatment of Advanced Ovarian Cancer with Malignant Ascites[J].Medical Information,2019,32(01):132.[doi:10.3969/j.issn.1006-1959.2019.18.044]
[7]黄馨禾,董丹丹,刘 倩.PARP抑制剂在卵巢癌治疗中的研究现状[J].医学信息,2019,32(21):26.[doi:10.3969/j.issn.1006-1959.2019.21.010]
 HUANG Xin-he,DONG Dan-dan,LIU Qian.Research Status of PARP Inhibitors in the Treatment of Ovarian Cancer[J].Medical Information,2019,32(01):26.[doi:10.3969/j.issn.1006-1959.2019.21.010]
[8]王 秦,张家佳,刘成桂,等.高表达IL-12卵巢癌细胞的建立[J].医学信息,2019,32(21):78.[doi:10.3969/j.issn.1006-1959.2019.21.024]
 WANG Qin,ZHANG Jia-jia,LIU Cheng-gui,et al.Establishment of High Expression of IL-12 Ovarian Cancer Cells[J].Medical Information,2019,32(01):78.[doi:10.3969/j.issn.1006-1959.2019.21.024]
[9]魏绮琪,张 颖.miR-200c与卵巢癌关系的研究[J].医学信息,2020,33(03):53.[doi:10.3969/j.issn.1006-1959.2020.03.016]
 WEI Qi-qi,ZHANG Ying.Study on the Relationship Between miR-200c and Ovarian Cancer[J].Medical Information,2020,33(01):53.[doi:10.3969/j.issn.1006-1959.2020.03.016]
[10]张小红.以自我管理为导向的5A护理模式对卵巢癌患者自我效能与负性情绪的影响[J].医学信息,2020,33(03):186.[doi:10.3969/j.issn.1006-1959.2020.03.063]
 ZHANG Xiao-hong.Effect of 5A Nursing Model Oriented on Self-management on Self-efficacy and Negative Emotions of Patients with Ovarian Cancer[J].Medical Information,2020,33(01):186.[doi:10.3969/j.issn.1006-1959.2020.03.063]

更新日期/Last Update: 2020-01-01