[1]伊学军,翟建新.胱抑素C检测及其在肾脏相关疾病中的应用[J].医学信息,2020,33(04):55-58.[doi:10.3969/j.issn.1006-1959.2020.04.017]
 YI Xue-jun,ZHAI Jian-xin.Cystatin C Detection and its Application in Kidney-related Diseases[J].Medical Information,2020,33(04):55-58.[doi:10.3969/j.issn.1006-1959.2020.04.017]
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胱抑素C检测及其在肾脏相关疾病中的应用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年04期
页码:
55-58
栏目:
综述
出版日期:
2020-02-15

文章信息/Info

Title:
Cystatin C Detection and its Application in Kidney-related Diseases
文章编号:
1006-1959(2020)04-0055-04
作者:
伊学军翟建新
(天津中医药大学第一附属医院检验科,天津 300193)
Author(s):
YI Xue-junZHAI Jian-xin
(Department of Laboratory Medicine,the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
关键词:
胱抑素C肾小球滤过率肾病肾损伤
Keywords:
Cystatin CGlomerular filtration rateKidney diseaseKidney injury
分类号:
R446.11
DOI:
10.3969/j.issn.1006-1959.2020.04.017
文献标志码:
A
摘要:
胱抑素C属于半胱氨酸蛋白酶抑制剂家族,是广泛存在于植物、细菌、病毒、原生动物和哺乳动物组织中的一类重要的蛋白酶,是评定肾小球滤过率(GFR)变化的内源性标志物。其生物学变异小,不受生理因素影响,因此灵敏度、特异性均优于GFR其他内源性标志物。大量研究表明胱抑素C与急性肾衰竭、糖尿病肾病、肝脏并发肾病等肾相关性疾病的发生密切相关。本文通过对胱抑素C的生物学特性和功能、检测方法及其作一综述,以期为临床检验提供参考。
Abstract:
Cystatin C belongs to the family of cysteine protease inhibitors. It is an important protease widely found in plant, bacterial, viral, protozoan and mammalian tissues. It is an endogenous marker to assess changes in glomerular filtration rate (GFR). Because its biological variation is small and is not affected by physiological factors, its sensitivity and specificity are better than other endogenous markers of GFR. Many studies have shown that cystatin C is closely related to the occurrence of kidney-related diseases such as acute renal failure, diabetic nephropathy, and liver-complicated nephropathy.This article reviews the biological characteristics and functions of cystatin C, its detection methods, and its application in kidney lesions and other diseases involving kidneys, in order to provide a reference for clinical tests.

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更新日期/Last Update: 2020-02-15