[1]赵林珊,刘 兴,耿 瑜.丁苯酞注射液治疗急性前循环脑梗死的效果[J].医学信息,2020,33(13):113-115.[doi:10.3969/j.issn.1006-1959.2020.13.032]
　ZHAO Lin-shan,LIU Xing,GENG Yu.Effect of Butylphthalide Injection on Acute Anterior Circulation Cerebral Infarction[J].Medical Information,2020,33(13):113-115.[doi:10.3969/j.issn.1006-1959.2020.13.032]
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丁苯酞注射液治疗急性前循环脑梗死的效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年13期
页码:
113-115
栏目:
临床研究
出版日期:
2020-07-01

文章信息/Info

Title:
Effect of Butylphthalide Injection on Acute Anterior Circulation Cerebral Infarction
文章编号:
1006-1959（2020）13-0113-03
作者:
赵林珊; 刘 兴; 耿 瑜
（天津市第四中心医院神经内科，天津 300140）
Author(s):
ZHAO Lin-shan; LIU Xing; GENG Yu
(Department of Neurology,Tianjin Fourth Central Hospital,Tianjin 300140,China)
关键词:
丁苯酞; 脑梗死; 梗死面积; 神经功能
Keywords:
Butylphthalide; Cerebral infarction; Infarct size; Nerve function
分类号:
R743.33
DOI:
10.3969/j.issn.1006-1959.2020.13.032
文献标志码:
A
摘要:
目的 评价丁苯酞注射液治疗急性前循环脑梗死的临床疗效。方法 选择2018年6月~2019年5月在我院住院的60例急性前循环脑梗死患者作为研究对象，随机分为治疗组和对照组，各30例，对照组在常规治疗基础上给予比达拉奉注射液静脉滴注，治疗组在对照组的基础上加用丁苯酞注射液静脉滴注。比较两组发病24 h、7、30 d的DWI阳性病灶（脑梗死）面积、NIHSS评分及Barthel指数，分析DWI阳性病灶面积与NIHSS评分及Barthel指数的相关性。结果 发病7 d，两组DWI阳性病灶面积均较发病24 h有所增加，但组间比较差异无统计学意义（P＞0.05）；发病30 d，两组DWI阳性病灶面积均较发病7 d缩小，且治疗组面积小于对照组，差异有统计学意义（P＜0.05）；发病30 d，两组NIHSS评分和Barthel指数与发病24 h比较均有改善，且治疗组改善优于对照组，差异有统计学意义（P＜0.05）；DWI阳性病灶面积与NIHSS评分呈正相关（r=0.742，P＜0.05），与Barthel指数呈负相关（r=-0.573，P＜0.05）。结论 丁苯酞注射液可以缩小急性脑梗死患者的病灶面积，改善神经功能，提升治疗效果，进而改善患者预后。
Abstract:
Objective To evaluate the clinical efficacy of butylphthalide injection in the treatment of acute anterior circulation cerebral infarction. Methods 60 patients with acute anterior circulation cerebral infarction who were hospitalized in our hospital from June 2018 to May 2019 were selected as the research object. They were randomly divided into a treatment group and a control group, each with 30 cases. The control group was given a comparison based on conventional treatment. Dalavone injection was intravenously infused, and the treatment group added intravenous injection of butylphthalide on the basis of the control group. The area of DWI positive lesions (cerebral infarction), NIHSS score and Barthel index at 24 h, 7 and 30 d of onset were compared between the two groups, and the correlation between the area of DWI positive lesions and NIHSS score and Barthel index was analyzed.Results At 7 d of onset, the area of DWI positive lesions in both groups increased compared with 24 h of onset, but there was no statistically significant difference between the groups (P>0.05); 30 d after onset, the area of DWI positive lesions in both groups decreased from 7 d of onset,and the area of the treatment group was smaller than that of the control group, the difference was statistically significant (P<0.05); 30 d after the onset, the NIHSS score and Barthel index of the two groups were improved compared with the onset of 24 h, and the improvement of the treatment group was better than the control group, the difference was statistically significant (P<0.05); the area of DWI positive lesions was positively correlated with NIHSS score (r=0.742,P<0.05), and negatively correlated with Barthel index (r=-0.573,P<0.05).Conclusion Butylphthalide injection can reduce the focal area of patients with acute cerebral infarction, improve nerve function, improve the therapeutic effect, and then improve the prognosis of patients.

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更新日期/Last Update: 1900-01-01