[1]代艳文,吴大富.宜昌地区妇女人乳头瘤病毒感染状况分析[J].医学信息,2020,33(16):143-144,148.[doi:10.3969/j.issn.1006-1959.2020.16.045]
　DAI Yan-wen,WU Da-fu.Analysis of Women’s Human Papillomavirus Infection in Yichang Area[J].Medical Information,2020,33(16):143-144,148.[doi:10.3969/j.issn.1006-1959.2020.16.045]
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宜昌地区妇女人乳头瘤病毒感染状况分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年16期
页码:
143-144,148
栏目:
调查分析
出版日期:
2020-08-15

文章信息/Info

Title:
Analysis of Women’s Human Papillomavirus Infection in Yichang Area
文章编号:
1006-1959（2020）16-0143-03
作者:
代艳文; 吴大富
（三峡大学附属仁和医院检验科，湖北 宜昌 443001）
Author(s):
DAI Yan-wen; WU Da-fu
(Department of Laboratory Medicine,Renhe Hospital,China Three Gorges University,Yichang 443001,Hubei,China)
关键词:
人乳头瘤病毒; 单一型感染; 宫颈癌
Keywords:
Human papillomavirus; Monotype infection; Cervical cancer
分类号:
R373.9
DOI:
10.3969/j.issn.1006-1959.2020.16.045
文献标志码:
A
摘要:
目的 了解宜昌地区妇女不同亚型人乳头瘤病毒（HPV）的感染状况及感染人群特征，为该市HPV感染的筛查及相关疾病的防治提供流行病学依据。方法 选取2019年1~12月三峡大学附属仁和医院进行HPV检测的3354例患者，应用PCR反向点杂交检测扩增产物与包被有特异性探针膜杂交，采用碱性凝酸酶系统定性检测，对宫颈脱落细胞中21种HPV基因型进行分型，并分析不同年龄段HPV亚型感染情况。结果 3354份标本中，共检出HPV阳性标本742份，总感染率为22.12%。宜昌地区妇女易感人群平均年龄为（39.52±11.30）岁，不同年龄段均有HPV感染，以35~45岁年龄段的女性居多。HPV基因型以单一型感染为主（73.32%），排前3位HPV高危亚型为HPV52（16.19%）、HPV58（12.05%）、HPV16（10.07%）；低危亚型主要以HPVCP8304（6.47%）为主。结论 宜昌地区妇女HPV感染的年龄主要集中于35~45岁年龄段，以单一型感染为主，其中高危型HPV52、HPV58和HPV16为HPV感染的主要亚型。
Abstract:
Objective To understand the infection status of different subtypes of human papillomavirus (HPV) among women in Yichang and the characteristics of the infected population, so as to provide an epidemiological basis for the screening of HPV infection and the prevention and treatment of related diseases in the city.Methods 3354 patients who were tested for HPV in Renhe Hospital Affiliated to China Three Gorges University from January to December 2019 were selected. PCR reverse dot hybridization was used to detect the hybridization of the amplified product with the membrane coated with a specific probe, and the alkaline coagulase system was used for qualitative analysis detection, classification of 21 HPV genotypes in cervical exfoliated cells, and analysis of HPV subtype infection in different age groups.Results Among the 3354 specimens, 742 HPV-positive specimens were detected, and the total infection rate was 22.12%. The average age of susceptible women in Yichang area was (39.52±11.30) years old, and HPV infections occur in different age groups, with the majority of women in the 35-45 age group. HPV genotypes were mainly single infection (73.32%), and the top 3 high-risk HPV subtypes were HPV52 (16.19%), HPV58 (12.05%), HPV16 (10.07%); the low-risk subtypes were mainly HPVCP8304 (6.47 %).Conclusion The age of HPV infection among women in Yichang area was mainly concentrated in the age group of 35 to 45 years old, and the single infection was the main type. Among them, high-risk HPV52, HPV58 and HPV16 were the main subtypes of HPV infection.

参考文献/References:

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更新日期/Last Update: 1900-01-01