[1]阿小英.阿司匹林联合地屈孕酮治疗习惯性流产患者的效果及对凝血、免疫功能的影响[J].医学信息,2020,33(19):138-140.[doi:10.3969/j.issn.1006-1959.2020.19.042]
　A Xiao-ying.The Effect of Aspirin Combined with Dydrogesterone in the Treatment of Patients with Habitual Abortion and Its Influence on Blood Coagulation and Immune Function[J].Medical Information,2020,33(19):138-140.[doi:10.3969/j.issn.1006-1959.2020.19.042]
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阿司匹林联合地屈孕酮治疗习惯性流产患者的效果及对凝血、免疫功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年19期
页码:
138-140
栏目:
药物与临床
出版日期:
2020-10-01

文章信息/Info

Title:
The Effect of Aspirin Combined with Dydrogesterone in the Treatment of Patients with Habitual Abortion and Its Influence on Blood Coagulation and Immune Function
文章编号:
1006-1959（2020）19-0138-03
作者:
阿小英
青海大学附属医院妇科，青海 西宁 810000
Author(s):
A Xiao-ying
Department of Gynecology,the Affiliated Hospital of Qinghai University,Xining 810000,Qinghai,China
关键词:
阿司匹林; 地屈孕酮; 习惯性流产; 凝血功能; 妊娠结局
Keywords:
Aspirin; Dydrogesterone; Habitual abortion; Coagulation function; Pregnancy outcome
分类号:
R714.2
DOI:
10.3969/j.issn.1006-1959.2020.19.042
文献标志码:
A
摘要:
目的 探讨阿司匹林联合地屈孕酮治疗习惯性流产患者的临床疗效及对凝血、免疫功能的影响。方法 选择我院2017年6月~2019年6月收治的238例习惯性流产患者，按照随机数字表法分为观察组和对照组，每组119例。两组均进行常规基础治疗，对照组给予黄体酮联合人绒毛膜促性腺激素治疗，观察组给予阿司匹林联合地屈孕酮治疗，比较两组妊娠结局、凝血功能[凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（Fbg）、D-二聚体、狼疮样抗凝物质比值（LAR）]及免疫功能[γ-干扰素（IFN-γ）及白细胞介素-4（IL-4）]。结果 观察组足月分娩占比高于对照组，流产、早产、死胎占比低于对照组，差异有统计学意义（P＜0.05）。治疗后，观察组PT、APTT高于对照组，Fbg、D-二聚体、LAR低于对照组，差异有统计学意义（P＜0.05）；观察组IFN-γ、IFN-γ/IL-4低于对照组，IL-4高于对照组，差异有统计学意义（P＜0.05）。结论 阿司匹林联合地屈孕酮治疗习惯性流产临床疗效确切，可有效调节机体凝血功能及免疫功能，改善妊娠结局，降低流产发生风险。
Abstract:
Objective To investigate the clinical efficacy of aspirin combined with dydrogesterone in the treatment of patients with habitual abortion and its effect on blood coagulation and immune function.Methods A total of 238 patients with habitual abortion admitted to our hospital from June 2017 to June 2019 were selected and divided into observation group and control group according to the random number table method, with 119 cases in each group. Both groups received routine basic treatment. The control group was treated with progesterone combined with human chorionic gonadotropin, and the observation group was treated with aspirin combined with dydrogesterone. The two groups were compared with pregnancy outcome, coagulation function [prothrombin time (PT), Activated partial thromboplastin time (APTT), fibrinogen (Fbg), D-dimer, lupus-like anticoagulant ratio (LAR)] and immune function [γ-interferon (IFN-γ) and interleukin -4 (IL-4)].Results The proportion of full-term delivery in the observation group was higher than that in the control group, and the proportion of miscarriage, premature delivery, and stillbirth was lower than that in the control group,the difference was statistically significant (P<0.05). After treatment, PT and APTT of the observation group were higher than those of the control group, and Fbg, D-dimer and LAR were lower than those of the control group, the difference was statistically significant (P<0.05); the observation group IFN-γ, IFN-γ/IL- 4 was lower than the control group, IL-4 was higher than the control group, the difference was statistically significant (P<0.05).Conclusion Aspirin combined with dydrogesterone had a definite clinical effect in the treatment of habitual abortion. It could effectively regulate the body’s blood coagulation function and immune function, improve pregnancy outcome, and reduced the risk of miscarriage.

参考文献/References:

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更新日期/Last Update: 1900-01-01