[1]郭 婷,王伟新,张丽丽.血浆置换联合分子吸附再循环系统治疗肝衰竭的疗效[J].医学信息,2020,33(24):104-106.[doi:10.3969/j.issn.1006-1959.2020.24.028]
　GUO Ting,WANG Wei-xin,ZHANG Li-li.The Effect of Plasma Exchange Combined with Molecular Adsorption Recirculation System in the Treatment of Liver Failure[J].Medical Information,2020,33(24):104-106.[doi:10.3969/j.issn.1006-1959.2020.24.028]
点击复制

血浆置换联合分子吸附再循环系统治疗肝衰竭的疗效()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年24期
页码:
104-106
栏目:
临床研究
出版日期:
2020-12-15

文章信息/Info

Title:
The Effect of Plasma Exchange Combined with Molecular Adsorption Recirculation System in the Treatment of Liver Failure
文章编号:
1006-1959（2020）24-0104-03
作者:
郭 婷; 王伟新; 张丽丽
宜春学院第二附属医院肝病科，江西 宜春 336000
Author(s):
GUO Ting; WANG Wei-xin; ZHANG Li-li
Department of Liver Diseases,Second Affiliated Hospital of Yichun University,Yichun 336000,Jiangxi,China
关键词:
血浆置换; 分子吸附再循环系统; 肝衰竭
Keywords:
Plasma exchange; Molecular adsorption recirculation system; Liver failure
分类号:
R575.3
DOI:
10.3969/j.issn.1006-1959.2020.24.028
文献标志码:
A
摘要:
目的 研究血浆置换联合分子吸附再循环系统治疗肝衰竭临床效果。方法 选取2019年3月~2020年9月我院治疗的42例肝衰竭患者为研究对象，采用随机数字表法分为观察组和对照组，各21例。对照组采用血浆置换治疗，观察组在对照组基础上联合应用分子吸附再循环系统治疗，比较两组临床治疗总有效率、肝功能指标、凝血功能指标、临床症状评分以及不良反应发生情况。结果 观察组临床治疗总有效率为85.71%，高于对照组的66.67%，差异有统计学意义（P＜0.05）；治疗后，观察组ALT、AST、TBIL低于对照组，差异有统计学意义（P＜0.05）；观察组PT短于对照组，PLT计数大于对照组，差异有统计学意义（P＜0.05）；观察组临床纳差、乏力、恶心呕吐、腹胀各症状评分均低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为9.52%，与对照组的14.28%比较，差异无统计学意义（P＞0.05）。结论 血浆置换联合分子吸附再循环系统治疗肝衰竭效果确切，可提高治疗总有效率，改善肝功能和凝血功能，减轻临床症状，且不增加不良反应发生几率。
Abstract:
Objective To study the clinical effect of plasma exchange combined with molecular adsorption recirculation system in the treatment of liver failure.Methods A total of 42 patients with liver failure treated in our hospital from March 2019 to September 2020 were selected as the research objects, and they were divided into observation group and control group by random number table method, with 21 cases in each group. The control group was treated with plasma exchange, and the observation group was combined with molecular adsorption recirculation system treatment on the basis of the control group. The total effective rate of clinical treatment, liver function indexes, blood coagulation function indexes, clinical symptom scores and adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 85.71%, which was higher than 66.67% in the control group,the difference was statistically significant (P<0.05); after treatment, the observation group had lower ALT, AST and TBIL than the control group,the difference was statistically significant (P＜0.05); PT of the observation group was shorter than that of the control group, and the PLT count was greater than that of the control group, the difference was statistically significant (P＜0.05); the observation group’s clinical anorexia, fatigue, nausea and vomiting, and abdominal distension were all lower than In the control group, the difference was statistically significant (P<0.05); the incidence of adverse reactions in the observation group was 9.52%, compared with 14.28% in the control group, the difference was not statistically significant (P>0.05).Conclusion Plasma exchange combined with molecular adsorption recirculation system has a definite effect in the treatment of liver failure. It can increase the total effective rate of treatment, improve liver function and coagulation function, reduce clinical symptoms, and does not increase the probability of adverse reactions.

参考文献/References:

[1]中华医学会感染病学分会肝衰竭与人工肝学组.非生物型人工肝治疗肝衰竭指南(2016年版)[J].中华临床感染病杂志,2016,9(2):97-103. [2]Karvellas CJ,Subramanian RM.Current Evidence for Extracorporeal Liver Support Systems in Acute Liver Failure and Acute-on-Chronic Liver Failure[J].Crit Care Clin,2016,32(3):439-451. [3]万维维.双重血浆分子吸附系统治疗急性肝功能衰竭的临床疗效观察[J].中华临床医师杂志,2016(7):196-197. [4]王银银.双重血浆分子吸附系统治疗肝衰竭的临床研究[D].浙江大学,2015. [5]冼永超,程书权,杨景毅,等.血浆置换联合持续性血浆滤过吸附术对HBV相关慢加急性肝功能衰竭的疗效[J].中华实验和临床感染病杂志(电子版),2016,10(6):674-679. [6]张斌,杨永耿,巩月英,等.双重血浆分子吸附治疗急性肝衰竭的临床应用[J].世界华人消化杂志,2015,23(29):4720-4724. [7]张宝文,阳学风,罗湘俊,等.双重血浆吸附、胆红素吸附及血浆置换治疗肝衰竭的疗效比较[J].中国现代医学杂志,2016,26(12):103-106. [8]杨黎冰,仝静,祖晓满,等.血浆置换治疗乙肝相关性肝衰竭的疗效分析[J].临床消化病杂志,2017,29(6):342-345. [9]徐晖,潘成,何雪明,等.血浆置换对肝衰竭患者血清炎症因子表达的影响[J].中外医学研究,2018,16(10):11-13. [10]方明霞,齐蕾.血浆置换治疗慢性乙型肝炎肝衰竭临床疗效观察[J].实用肝脏病志,2015,18(3):292-293. [11]陈亦婷,吴渚,陶少华.高容量血浆置换在危重症中的应用[J].中国小儿急救医学,2018,25(5):348-350. [12]王淑英,王开利,冯艳青,等.不同种类血浆用于慢加急肝衰竭患者血浆置换的疗效比较[J].世界华人消化杂志,2015,23(13):2135-2142. [13]Li M,Wang Z,Wang Y,et al.Part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration in the treatment of severe acute liver failure[J].Experimental&Therapeutic Medicine,2016,12(4):2582-2584. [14]张琳,赵守松.人工肝血浆置换治疗肝衰竭的临床观察[J].临床肝胆病杂志,2014,30(10):1015-1019. [15]程小彬,田萍.血浆胆红素吸附联合小剂量血浆置换治疗严重肝衰竭的临床研究[J].国际检验医学杂志,2017,38(22):3196-3198.

相似文献/References:

[1]张秀灵,牟春燕,李 武.非生物人工肝支持系统的临床应用现状及进展[J].医学信息,2018,31(02):40.[doi:10.3969/j.issn.1006-1959.2018.02.014]
　ZHANG Xiu-ling,MOU Chun-yan,LI Wu.Current Status and Progress of Clinical Application of Abiotic Artificial Liver Support System[J].Medical Information,2018,31(24):40.[doi:10.3969/j.issn.1006-1959.2018.02.014]
[2]刘燕燕,曾万江,徐晓燕,等.产后并发血栓性血小板减少性紫癜1例报告及文献复习[J].医学信息,2019,32(09):189.[doi:10.3969/j.issn.1006-1959.2019.09.065]
[3]李 鑫,阙文君,余泽波.以冷凝集素综合征为首发表现的淋巴瘤1例[J].医学信息,2020,33(12):188.[doi:10.3969/j.issn.1006-1959.2020.12.064]
[4]周 雪,童春帆.血液成分单采和血浆置换治疗血液病的临床疗效观察[J].医学信息,2022,35(08):130.[doi:10.3969/j.issn.1006-1959.2022.08.033]
　ZHOU Xue,TONG Chun-fan.Clinical Effect of Single Blood Component Collection and Plasma Exchange in the Treatment of Hematologic Diseases[J].Medical Information,2022,35(24):130.[doi:10.3969/j.issn.1006-1959.2022.08.033]
[5]金 英.血浆置换联合大剂量甲泼尼龙对特发性血小板减少性紫癜患者血小板相关免疫球蛋白及T细胞亚群的影响[J].医学信息,2022,35(09):131.[doi:10.3969/j.issn.1006-1959.2022.09.032]
　JIN Ying.Effect of Plasma Exchange Combined with High-dose Methylprednisolone on Platelet-related Immunoglobulin and T Cell Subsets in Patients with Idiopathic Thrombocytopenic Purpura[J].Medical Information,2022,35(24):131.[doi:10.3969/j.issn.1006-1959.2022.09.032]
[6]李 冬,方长太,程高翔.双重血浆分子吸附模式人工肝在重症急性肝衰竭患者中的应用效果[J].医学信息,2022,35(09):147.[doi:10.3969/j.issn.1006-1959.2022.09.037]
　LI Dong,FANG Chang-tai,CHENG Gao-xiang.Application Effect of Dual Plasma Molecular Adsorption System Artificial Liver in Patients with Severe Acute Liver Failure[J].Medical Information,2022,35(24):147.[doi:10.3969/j.issn.1006-1959.2022.09.037]

更新日期/Last Update: 1900-01-01