[1]陈亚楠.急性脑梗塞患者TNF-α、IL-6、CRP、MDA 和SOD水平及其临床意义[J].医学信息,2020,33(24):107-109.[doi:10.3969/j.issn.1006-1959.2020.24.029]
　CHEN Ya-nan.The Levels of TNF-α,IL-6,CRP,MDA and SOD in Patients with Acute Cerebral Infarction and Their Clinical Significance[J].Medical Information,2020,33(24):107-109.[doi:10.3969/j.issn.1006-1959.2020.24.029]
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急性脑梗塞患者TNF-α、IL-6、CRP、MDA 和SOD水平及其临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年24期
页码:
107-109
栏目:
临床研究
出版日期:
2020-12-15

文章信息/Info

Title:
The Levels of TNF-α,IL-6,CRP,MDA and SOD in Patients with Acute Cerebral Infarction and Their Clinical Significance
文章编号:
1006-1959（2020）24-0107-03
作者:
陈亚楠
天津市东丽区东丽医院神经内科，天津 300300
Author(s):
CHEN Ya-nan
Department of Neurology,Dongli Hospital,Dongli District,Tianjin 300300,China
关键词:
脑梗塞; 肿瘤坏死因子; 白介素; 日常生活能力
Keywords:
Cerebral infarction; Tumor necrosis factor; Interleukin; Ability of daily living
分类号:
R74
DOI:
10.3969/j.issn.1006-1959.2020.24.029
文献标志码:
A
摘要:
目的 观察急性脑梗塞患者的TNF-α、IL-6、CRP、MDA和SOD水平，并分析其临床意义。方法 选取2017年1月~2019年2月在我院接受治疗的急性脑梗塞患者100例作为研究对象，根据其梗塞面积分为大面积梗塞组25例和中小面积梗塞组75例，同时选取同期在我院接受体检的100名健康成年人作为对照组。比较急性脑梗塞患者和对照组、大面积梗塞组和中小面积梗塞组患者肿瘤坏死因子（TNF-α）、白介素-6（IL-6）、C反应蛋白（CRP）、丙二醛（MDA）、超氧化物歧化酶（SOD）水平和日常生活能力的差异。结果 急性脑梗塞患者血清TNF-α、IL-6、CRP、MDA水平高于对照组，SOD水平、日常生活能力低于对照组，差异有统计学意义（P＜0.05）；大面积梗塞组血清TNF-α、IL-6、CRP、MDA水平高于中小面积梗塞组，SOD水平、日常生活能力低于中小面积梗塞组，差异有统计学意义（P＜0.05）。结论 急性脑梗塞患者的TNF-α、IL-6、CRP、MDA水平较健康人群高，SOD水平和日常生活能力较健康人群低，且与梗塞面积相关。
Abstract:
Objective To observe the levels of TNF-α, IL-6, CRP, MDA and SOD in patients with acute cerebral infarction, and analyze their clinical significance.Methods A total of 100 patients with acute cerebral infarction who were treated in our hospital from January 2017 to February 2019 were selected as the research objects. According to their infarct size, they were divided into 25 cases in the large-area infarction group and 75 cases in the medium- and small-area infarction group. The same period was selected. 100 healthy adults who underwent physical examination in our hospital served as the control group. Comparing patients with acute cerebral infarction and control group, large-area infarction group and small-to-medium-area infarction group, tumor necrosis factor (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), malondialdehyde (MDA) , Superoxide dismutase (SOD) levels and differences in activities of daily living.Results The levels of serum TNF-α, IL-6, CRP, and MDA in patients with acute cerebral infarction were higher than those in the control group, and the levels of SOD and activities of daily living were lower than those in the control group,the difference was statistically significant (P＜0.05);Serum levels of TNF-α, IL-6, CRP, and MDA in the large-area infarct group were higher than those in the small-medium-sized infarct group, and the SOD level and activities of daily living were lower than those in the small-medium-sized infarct group,the difference was statistically significant (P<0.05).Conclusion The levels of TNF-α, IL-6, CRP, and MDA in patients with acute cerebral infarction are higher than those in healthy people, while SOD levels and activities of daily living are lower than those in healthy people, and are related to the infarct size.

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更新日期/Last Update: 1900-01-01