[1]郑楚丽,宋 硕,谭晓瑜,等.自噬在宫颈癌发生发展中的作用[J].医学信息,2021,34(05):9-11.[doi:10.3969/j.issn.1006-1959.2021.05.003]
 ZHENG Chu-li,SONG Shuo,TAN Xiao-yu,et al.The Role of Autophagy in the Occurrence and Development of Cervical Cancer[J].Medical Information,2021,34(05):9-11.[doi:10.3969/j.issn.1006-1959.2021.05.003]
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自噬在宫颈癌发生发展中的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年05期
页码:
9-11
栏目:
出版日期:
2021-03-01

文章信息/Info

Title:
The Role of Autophagy in the Occurrence and Development of Cervical Cancer
文章编号:
1006-1959(2021)05-0009-03
作者:
郑楚丽宋 硕谭晓瑜
(广东医科大学,广东 湛江 524000)
Author(s):
ZHENG Chu-liSONG ShuoTAN Xiao-yuet al.
(Department of Obstetrics and Gynecology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050, Inner Mongolia,China)
关键词:
自噬宫颈癌Beclin1LC3
Keywords:
Cervical cancerEpidemiologyEtiology
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2021.05.003
文献标志码:
A
摘要:
宫颈癌起源于宫颈上皮内瘤变,人乳头瘤病毒(HPV)持续感染是其高危因素。而HPV致病过程伴随着细胞的异常代谢、基因的异常调控。自噬指细胞利用溶酶体降解细胞质中错误折叠的蛋白质及受损细胞器等,重新利用降解物质及胞内有害物质的过程,以维持细胞内环境稳定。正常状态下细胞的自噬维持在低水平,当细胞处在不利因素条件下,自噬也会被激活应对不利因素。在宫颈癌发生发展过程中,自噬相关蛋白表达被抑制,如Beclin1、LC3表达水平降低,自噬下调诱导肿瘤的发生。本文将对自噬在宫颈癌发生发展中的作用,及其在宫颈癌治疗中的应用进展进行阐述。
Abstract:
Cervical cancer is one of the major malignant tumors threatening the health and life of women around the world, and its incidence is second only to breast cancer.In recent decades, with the development of social economy, the improvement of living standard, the popularization of medical knowledge, the enhancement of women’s health awareness, the promotion of medical level, and the "three-step" screening method for cervical lesions, the vigorous promotion of the "two cancers" screening and the development of general cervical cancer treatment, cervical cancer in my country has shown a series of new changes.This article now reviews the current status of cervical cancer epidemiology and research on high-risk factors of cervical cancer in my country, aiming to provide a reference for the future development of cervical cancer prevention strategies and diagnosis and treatment measures.

参考文献/References:

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更新日期/Last Update: 1900-01-01