[1]杨立顺,陈思佳,康建华.miRNA和脂联素在2型糖尿病发病机制中的研究[J].医学信息,2021,34(08):50-52,56.[doi:10.3969/j.issn.1006-1959.2021.08.013]
 YANG Li-shun,CHEN Si-jia,KANG Jian-hua.Study on miRNA and Adiponectin in the Pathogenesis of Type 2 Diabetes Mellitus[J].Medical Information,2021,34(08):50-52,56.[doi:10.3969/j.issn.1006-1959.2021.08.013]
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miRNA和脂联素在2型糖尿病发病机制中的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年08期
页码:
50-52,56
栏目:
综述
出版日期:
2021-04-15

文章信息/Info

Title:
Study on miRNA and Adiponectin in the Pathogenesis of Type 2 Diabetes Mellitus
文章编号:
1006-1959(2021)08-0050-04
作者:
杨立顺陈思佳康建华
(天津市北辰区中医医院检验科,天津 300400)
Author(s):
YANG Li-shunCHEN Si-jiaKANG Jian-hua
(Department of Clinical Laboratory,Tianjin Beichen Traditional Chinese Medicine Hospital,Tianjin 300400,China)
关键词:
脂联素miRNA2型糖尿病
Keywords:
AdiponectinmiRNAType 2 diabetes mellitus
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2021.08.013
文献标志码:
A
摘要:
2型糖尿病是由胰岛素抵抗及分泌不足引起的代谢类疾病,严重危害人类的健康。脂联素属于可溶性防御性胶原家族成员,具有抗炎症、增加胰岛素敏感性以及影响胰岛β细胞分泌胰岛素等作用。微小RNA(miRNA)是一类小分子非编码RNA,其通过影响胰岛细胞功能,引起胰岛素抵抗,从而参与糖尿病的发病。本文就脂联素的功能、miRNA在糖尿病中的调节作用、miRNA与脂联素的调节关系及其在T2DM中的作用作一综述,旨在为2型糖尿病患者及易感人群的早期诊断筛查和治疗提供参考。
Abstract:
Type 2 diabetes mellitusis a metabolic disease caused by insulin resistance and insufficient secretion, which seriously endangers human health.Adiponectin is a member of the soluble defensive collagen family, which has the functions of anti-inflammatory, increasing insulin sensitivity and affecting the secretion of insulin by pancreatic β cells.MicroRNA (miRNA) is a type of small molecule non-coding RNA, miRNA affects the function of pancreatic islet cells, causes insulin resistance, and participates in the pathogenesis of diabetes.This article reviews the function of adiponectin, the regulatory role of miRNA in diabetes, the regulatory relationship between miRNA and adiponectin, and its role in T2DM, aiming to screen for early diagnosis of type 2 diabetes patients and susceptible people Provide reference for investigation and treatment.

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更新日期/Last Update: 1900-01-01