[1]王 楠.血栓通注射液对急性冠脉综合征介入治疗后血脂、炎症因子及内皮功能的影响[J].医学信息,2021,34(09):122-124.[doi:10.3969/j.issn.1006-1959.2021.09.032]
　WANG Nan.Effect of Xueshuantong Injection on Blood Lipid,Inflammatory Factors and Endothelial Function After Interventional Therapy for Acute Coronary Syndrome[J].Medical Information,2021,34(09):122-124.[doi:10.3969/j.issn.1006-1959.2021.09.032]
点击复制

血栓通注射液对急性冠脉综合征介入治疗后血脂、炎症因子及内皮功能的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年09期
页码:
122-124
栏目:
论著
出版日期:
2021-05-01

文章信息/Info

Title:
Effect of Xueshuantong Injection on Blood Lipid,Inflammatory Factors and Endothelial Function After Interventional Therapy for Acute Coronary Syndrome
文章编号:
1006-1959（2021）09-0122-03
作者:
王 楠
（佳木斯市中心医院神经内科，黑龙江 佳木斯 154002）
Author(s):
WANG Nan
(Department of Neurology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
血栓通; 急性冠脉综合征; 炎症因子; 血管内皮功能
Keywords:
Xueshuantong; Acute coronary syndrome; Inflammatory factors; Vascular endothelial function
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2021.09.032
文献标志码:
A
摘要:
目的 观察血栓通注射液对急性冠脉综合征（ACS）患者介入治疗预后的影响。方法 选取2019年10月~2020年10月在我院行介入治疗的84例ACS患者作为研究对象，采用随机数字表法分为对照组和观察组，各42例。对照组采用常规治疗，观察组在对照组基础上应用血栓通注射液治疗，比较两组血脂、炎症因子、血管内皮功能及不良反应发生情况。结果 两组TC、TG、LDL-C低于治疗前，HDL-C高于治疗前，且观察组TC、TG、LDL-C低于对照组，HDL-C高于对照组，差异均有统计学意义（P＜0.05）；两组血清CRP、TNF-α、IL-6均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；两组ET、vWF均低于治疗前，NO高于治疗前，且观察组ET、vWF低于对照组，NO高于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率（7.14%）与对照组（9.52%）比较，差异无统计学意义（P＞0.05）。结论 血栓通注射液可抑制急性冠脉综合征患者介入术后的炎症反应，降低炎症因子水平，控制血脂水平，改善血管内皮功能，且不会增加不良反应，具有良好安全性。
Abstract:
Objective To observe the effect of Xueshuantong injection on the prognosis of patients with acute coronary syndrome (ACS) interventional therapy.Methods A total of 84 patients with ACS who underwent interventional therapy in our hospital from October 2019 to October 2020 were selected as the research objects. They were divided into control group and observation group by random number table method, with 42 cases in each group.The control group was treated with conventional treatment, and the observation group was treated with Xueshuantong injection on the basis of the control group. The blood lipids, inflammatory factors, vascular endothelial function and adverse reactions were compared between the two groups.Results TC, TG, LDL-C of the two groups were lower than before treatment, HDL-C was higher than before treatment, and TC, TG, LDL-C of the observation group were lower than those of the control group, and HDL-C was higher than the control group,the differences were statistically significant (P＜0.05);Serum CRP, TNF-α and IL-6 in the two groups were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05);Both ET and vWF were lower than before treatment, NO was higher than before treatment, and ET and vWF in the observation group were lower than the control group, and NO was higher than the control group, the difference was statistically significant (P<0.05);Compared with the control group (9.52%) in the incidence of adverse reactions in the observation group (7.14%), there was no statistically significant difference (P>0.05).Conclusion Xueshuantong injection can inhibit the inflammatory reaction of patients with acute coronary syndrome after interventional operation, reduce the level of inflammatory factors, control the level of blood lipids, and improve the vascular endothelial function without increasing adverse reactions. It has good safety.

参考文献/References:

[1]于尧.丁苯酞软胶囊治疗缺血性脑卒中神经功能的效果分析[J].北方药学,2019,16(6):11-12. [2]樊秀雷.丁苯酞软胶囊联合尿激酶对缺血性脑卒中患者神经功能、不良反应及日常生活能力的影响[J].中国实用医药,2018,13(18):107-108. [3]何仲春,肖慧宇,石顺华,等.血栓通联合低分子肝素治疗对急性冠脉综合征患者PCI术后炎症因子及内皮功能的影响[J].现代生物医学进展,2017,17(18):3540-3543. [4]李健,杨治平,张国盛,等.血栓通联合低分子肝素治疗高龄急性冠脉综合征介入治疗术后患者临床分析[J].内科,2016,11(1):16-19. [5]季倩倩,张文高,杨传华,等.张文高教授益气温阳活血与解毒配伍治疗急性冠脉综合征经验[J].中西医结合心脑血管病杂志,2016,14(6):662-663. [6]胡其源,岳静雯,王寅.阿司匹林与氯吡格雷双抗联合早期应用血栓通、低分子肝素治疗不稳定心绞痛的疗效和不良反应[J].实用临床医药杂志,2017,21(5):29-31,45. [7]焦燕,李江,李红燕.血栓通注射液对急性脑梗死患者血清超敏C反应蛋白及白细胞介素-6水平的影响[J].现代中西医结合杂志,2016,22(10):223-224. [8]刘红樱,王长谦,解玉水,等.心悦胶囊对介入后急性冠脉综合征患者预后的影响[J].中成药,2015,37(6):1191-1196． [9]艾秋玲,左雪容,杨静,等.西洛他唑片对急性冠脉综合征经皮冠状动脉介入术后患者内皮功能的影响[J].中国临床药理学杂志,2020,36(17):2610-2613. [10]张薇薇,董宏伟,张文泉.丹红注射液对老年急性冠脉综合征冠状动脉介入术后血管内皮功能及炎性因子水平的影响[J].中国老年学杂志,2016,36(22):5591. [11]何凤莲.经皮冠状动脉介入治疗对急性冠脉综合征伴左心衰竭患者心功能的影响分析[J].中西医结合心血管病电子杂志,2020,8(1):55-56. [12]路陆,杨静,姚天宇.血府逐瘀汤联合心脉隆注射液对急性冠脉综合征患者经皮冠状动脉介入术后影响[J].辽宁中医药大学学报,2020,192(4):176-179. [13]崔勇波.经皮冠脉介入手术时机对急性心肌梗死后左室重构及心功能的价值体会[J].淮海医药,2020,38(1):63-65. [14]马晶茹,邰玉玲.早期心脏康复对急性冠状动脉综合征患者经皮冠状动脉介入术后疗效的影响[J].中国医科大学学报,2020(9):803-806. [15]胡蕊,郭书文,杨涛.温阳通络方对急性心肌梗死经皮冠状动脉介入治疗术后患者心室重构和血管内皮功能的影响[J].河北中医,2019,41(10):52-57.

相似文献/References:

[1]赵殿儒,祁景蕊.不同剂量瑞舒伐他汀对急性冠脉综合征患者心功能和炎症因子的影响[J].医学信息,2019,32(01):148.[doi:10.3969/j.issn.1006-1959.2019.01.046]
　ZHAO Dian-ru,YAN Jing-rui.Effects of Different Doses of Rosuvastatin on Cardiac Function and Inflammatory Factors in Patients with Acute Coronary Syndrome[J].Medical Information,2019,32(09):148.[doi:10.3969/j.issn.1006-1959.2019.01.046]
[2]镡子鸣,叶怀阔,任长杰.超敏C反应蛋白及妊娠相关血浆蛋白A预测再发急性冠脉综合征的临床价值[J].医学信息,2019,32(08):173.[doi:10.3969/j.issn.1006-1959.2019.08.055]
　TAN Zi-ming,YE Huai-kuo,et al.Clinical Value of High-sensitivity C-reactive Protein and Pregnancy-associated Plasma Protein A in Predicting Recurrent Acute Coronary Syndrome[J].Medical Information,2019,32(09):173.[doi:10.3969/j.issn.1006-1959.2019.08.055]
[3]梁道博,姚卜飞,夏双燕.氯吡格雷联合阿司匹林治疗急性冠脉综合征疗效与 安全性的Meta分析[J].医学信息,2019,32(11):76.[doi:10.3969/j.issn.1006-1959.2019.11.021]
　LIANG Dao-bo,YAO Bu-fei,XIA Shuang-yan.Meta-analysis of the Efficacy and Safety of Clopidogrel Combined with Aspirin in the Treatment of Acute Coronary Syndrome[J].Medical Information,2019,32(09):76.[doi:10.3969/j.issn.1006-1959.2019.11.021]
[4]张牧秋,古俊楠,刘 瑜,等.NOACS治疗房颤合并急性冠脉综合征的研究[J].医学信息,2019,32(13):28.[doi:10.3969/j.issn.1006-1959.2019.13.010]
　ZHANG Mu-qiu,GU Jun-nan,LIU Yu,et al.Study of NOACS in the Treatment of Atrial Fibrillation Complicated with Acute Coronary Syndrome[J].Medical Information,2019,32(09):28.[doi:10.3969/j.issn.1006-1959.2019.13.010]
[5]王建强,刘 瑜,张牧秋,等.房颤伴ACS患者经皮冠状动脉介入术后抗栓研究[J].医学信息,2019,32(14):35.[doi:10.3969/j.issn.1006-1959.2019.14.013]
　WANG Jian-qiang,LIU Yu,ZHANG Mu-qiu,et al.Study on Antithrombotic after Percutaneous Coronary Intervention in Patients with Atrial Fibrillation and ACS[J].Medical Information,2019,32(09):35.[doi:10.3969/j.issn.1006-1959.2019.14.013]
[6]孙 洋,高 山,宋 京,等.血尿酸、同型半胱氨酸、脑钠肽、肌钙蛋白Ⅰ与急性冠脉综合征病变程度的相关性[J].医学信息,2020,33(02):105.[doi:10.3969/j.issn.1006-1959.2020.02.028]
　SUN Yang,GAO Shan,SONG Jing,et al.Correlation Between Serum Uric Acid,Homocysteine,Brain Natriuretic Peptide,TroponinⅠ and the Severity of Acute Coronary Syndrome[J].Medical Information,2020,33(09):105.[doi:10.3969/j.issn.1006-1959.2020.02.028]
[7]史作霞,张文彦,李 馨,等.改良桡动脉止血器在老年ACS患者动脉穿刺后压迫止血中的效果[J].医学信息,2020,33(02):184.[doi:10.3969/j.issn.1006-1959.2020.02.060]
　SHI Zuo-xia,ZHANG Wen-yan,LI Xin,et al.Evaluation of Improved Radial Arterial Hemostatic Device in Compression Hemostasis After Arterial Puncture in Elderly Patients with ACS[J].Medical Information,2020,33(09):184.[doi:10.3969/j.issn.1006-1959.2020.02.060]
[8]夏 雪,顾 明.急性冠脉综合征患者血清Gal-3浓度与病变程度及肌钙蛋白的相关性[J].医学信息,2021,34(01):116.[doi:10.3969/j.issn.1006-1959.2021.01.030]
　XIA Xue,GU Ming.Correlation of Serum Gal-3 Concentration with Disease Degree and Troponin in Patients with Acute Coronary Syndrome[J].Medical Information,2021,34(09):116.[doi:10.3969/j.issn.1006-1959.2021.01.030]
[9]董 谦,陈 康,王伟佳.多重指标在急性冠脉综合症中的应用价值[J].医学信息,2021,34(05):172.[doi:10.3969/j.issn.1006-1959.2021.05.050]
　DONG Qian,CHEN Kang,WANG Wei-jia.The Application Value of Multiple Indexes in Acute Coronary Syndrome[J].Medical Information,2021,34(09):172.[doi:10.3969/j.issn.1006-1959.2021.05.050]
[10]李文军.脂蛋白相关磷脂酶A2、血清胱抑素C在急性冠脉综合征患者中表达及意义[J].医学信息,2021,34(13):70.[doi:10.3969/j.issn.1006-1959.2021.13.018]
　LI Wen-jun.Expression and Significance of Lipoprotein-related Phospholipase A2 and Serum Cystatin C in Patients with Acute Coronary Syndrome[J].Medical Information,2021,34(09):70.[doi:10.3969/j.issn.1006-1959.2021.13.018]

更新日期/Last Update: 1900-01-01