[1]黄 芳,任建云,申晓敏,等.某传染病医院耐碳青霉烯类肠杆菌科细菌的分布特点及耐药性分析[J].医学信息,2021,34(11):144-147.[doi:10.3969/j.issn.1006-1959.2021.11.040]
　HUANG Fang,REN Jian-yun,SHEN Xiao-min,et al.Distribution Characteristics and Drug Resistance Analysis of Carbapenem-resistant Enterobacteriaceae in an Infectious Disease Hospital[J].Medical Information,2021,34(11):144-147.[doi:10.3969/j.issn.1006-1959.2021.11.040]
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某传染病医院耐碳青霉烯类肠杆菌科细菌的分布特点及耐药性分析()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年11期
页码:
144-147
栏目:
调查分析
出版日期:
2021-06-01

文章信息/Info

Title:
Distribution Characteristics and Drug Resistance Analysis of Carbapenem-resistant Enterobacteriaceae in an Infectious Disease Hospital
文章编号:
1006-1959（2021）11-0144-04
作者:
黄 芳; 任建云; 申晓敏; 等
（天津市第二人民医院检验科，天津 300192）
Author(s):
HUANG Fang; REN Jian-yun; SHEN Xiao-min; et al.
(Department of Laboratory Medicine,Tianjin Second People’s Hospital,Tianjin 300192,China)
关键词:
耐碳青霉烯类肠杆菌科细菌; 药敏试验; 耐药率
Keywords:
Carbapenem-resistant Enterobacteriaceae; Drug susceptibility test; Drug resistance rate
分类号:
R446.5
DOI:
10.3969/j.issn.1006-1959.2021.11.040
文献标志码:
A
摘要:
目的 探讨本院2016年1月~2020年11月耐碳青霉烯类肠杆菌科细菌（CRE）的分布及耐药性，为临床预防和治疗CRE提供参考依据。方法 回顾性分析我院2016年1月~2020年11月从临床标本中分离的112株CRE的分布及耐药性，使用法国生物梅里埃公司的VITEK-Compact Ⅱ进行细菌鉴定和药敏试验，英国OXOID纸片行扩散法（K-B法）作为药敏试验补充方法，改良Hodge试验对CRE产碳青霉烯酶情况进行确认。结果 2016年1月~2020年11月分离出112株CRE总检出率为5.62%，检出率呈逐年上升趋势；CRE菌种主要以肺炎克雷伯菌为主，其次为大肠埃希菌、阴沟肠杆菌；标本类型主要以痰液为主，其次为尿液和血液；我院感染CRE患者以≥60岁年龄为主（55.36%）。药敏试验结果显示，我院CRE菌株对替加环素的耐药率最低（4.46%），其次为阿米卡星（13.39%），对于其余大多数常用抗菌药物耐药率较高；CRE菌种间耐药率存在差异，尤其是耐碳青霉烯类肺炎克雷伯菌（CRKP）较其他菌种表现出更高的耐药率。结论 我院近5年CRE检出率逐年上升，且对于常用的抗菌药物耐药率较高。临床应重视对CRE的耐药性监测，尤其是对CRKP的重点防控，规范临床合理使用抗菌药物，采取综合防控措施，阻止CRE的感染和传播。
Abstract:
Objective To investigate the distribution and drug resistance of carbapenem-resistant Enterobacteriaceae (CRE) in our hospital from January 2016 to November 2020, and provide a reference for clinical prevention and treatment of CRE.Methods To retrospectively analyze the distribution and drug resistance of 112 CRE strains isolated from clinical specimens in our hospital from January 2016 to November 2020.Use VITEK-Compact Ⅱ from France BioMérieux for bacterial identification and drug sensitivity test,the British OXOID paper-line diffusion method (K-B method) was used as a supplementary method for the drug susceptibility test, and the modified Hodge test confirmed the production of carbapenemase by CRE.Results The total detection rate of 112 CRE isolates from January 2016 to November 2020 was 5.62%, and the detection rate was increasing year by year;CRE strains are mainly Klebsiella pneumoniae, followed by Escherichia coli and Enterobacter cloacae; specimen types are mainly sputum, followed by urine and blood;The majority of patients with CRE infection in our hospital are ≥60 years old (55.36%).The results of the drug sensitivity test showed that the CRE strains in our hospital had the lowest resistance rate to tigecycline (4.46%), followed by amikacin (13.39%), and the resistance rate to most of the other commonly used antibacterial drugs was higher;There were differences in the drug resistance rate among CRE strains, especially the carbapenem-resistant Klebsiella pneumoniae (CRKP) had a higher drug resistance rate than other strains.Conclusion The detection rate of CRE in our hospital has increased year by year in the past 5 years, and the resistance rate to commonly used antimicrobial drugs is relatively high.Clinics should pay attention to the monitoring of CRE resistance, especially the key prevention and control of CRKP, standardize the clinical rational use of antibacterial drugs, and adopt comprehensive prevention and control measures to prevent the infection and spread of CRE.

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更新日期/Last Update: 1900-01-01