[1]左耀武.长春西汀联合丹参川芎嗪治疗脑血管痉挛性头痛的疗效及对血清同型半胱氨酸水平的影响[J].医学信息,2021,34(23):129-131.[doi:10.3969/j.issn.1006-1959.2021.23.038]
　ZUO Yao-wu.Effect of Vinpocetine Combined with Salvia Miltiorrhiza Ligustrazine on Cerebral Vasospasm Headache and its Effect on Serum Homocysteine Level[J].Medical Information,2021,34(23):129-131.[doi:10.3969/j.issn.1006-1959.2021.23.038]
点击复制

长春西汀联合丹参川芎嗪治疗脑血管痉挛性头痛的疗效及对血清同型半胱氨酸水平的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年23期
页码:
129-131
栏目:
论著
出版日期:
2021-12-01

文章信息/Info

Title:
Effect of Vinpocetine Combined with Salvia Miltiorrhiza Ligustrazine on Cerebral Vasospasm Headache and its Effect on Serum Homocysteine Level
文章编号:
1006-1959（2021）23-0129-03
作者:
左耀武
（南京市溧水区人民医院神经内科，江苏 南京 211200）
Author(s):
ZUO Yao-wu
(Department of Neurology,Lishui District People’s Hospital,Nanjing 211200,Jiangsu,China)
关键词:
长春西汀; 丹参川芎嗪; 脑血管痉挛性头痛; 血清同型半胱氨酸
Keywords:
Vinpocetine; Salvia miltiorrhiza ligustrazine; Cerebral vasospasm headache; Serum homocysteine
分类号:
R743
DOI:
10.3969/j.issn.1006-1959.2021.23.038
文献标志码:
A
摘要:
目的 分析长春西汀联合丹参川芎嗪治疗脑血管痉挛性头痛的临床疗效及对血清同型半胱氨酸（Hcy）水平的影响。方法 选取我院2016年1月-2020年12月收治的80例脑血管痉挛性头痛患者作为研究对象，采用随机数字表法分为观察组和对照组，各40例。对照组予以长春西汀治疗，观察组予以长春西汀联合丹参川芎嗪治疗，比较两组临床疗效、脑部血流速度[大脑中动脉（MCA）、大脑前动脉（ACA）、大脑后动脉（PCA）]、生活质量、Hcy水平及不良反应发生情况。结果 观察组总有效率为95.00%，高于对照组的65.00%，差异有统计学意义（P＜0.05）；观察组MCA、ACA、PCA、Hcy水平低于对照组，差异有统计学意义（P＜0.05）；观察组心理健康、情感健康、躯体健康、社会健康以及认知评分高于对照组，差异有统计学意义（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 长春西汀联合丹参川芎嗪治疗脑血管痉挛性头痛疗效确切，可有效改善脑部血流速度，降低Hcy水平，有利于促进患者日常活动能力的恢复，提高生活质量，且联合治疗不会增加不良反应发生率。
Abstract:
Objective To analyze the clinical efficacy of vinpocetine combined with salvia miltiorrhiza ligustrazine in the treatment of cerebral vasospasm headache and its influence on serum homocysteine (Hcy) level.Methods A total of 80 patients with cerebral vasospasm headache admitted to our hospital from January 2016 to December 2020 were selected as the research objects. They were divided into observation group and control group by random number table method, with 40 cases in each group. The control group was treated with vinpocetine, and the observation group was treated with vinpocetine combined with salvia miltiorrhiza ligustrazine. The clinical efficacy, cerebral blood flow velocity [middle cerebral artery (MCA), anterior cerebral artery (ACA), posterior cerebral artery (PCA)], quality of life, Hcy level, and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.00%, which was higher than 65.00% of the control group, and the difference was statistically significant (P<0.05). MCA, ACA, PCA and Hcy in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05).The scores of mental health, emotional health, physical health, social health and cognition in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Vinpocetine combined with salvia miltiorrhiza ligustrazine is effective in the treatment of cerebral vasospasm headache, which can effectively improve cerebral blood flow velocity, reduce Hcy level, promote the recovery of patients’ daily activity ability, improve the quality of life, and the combined treatment does not increase the incidence of adverse reactions.

参考文献/References:

[1]吴国访,段红霞,张丽.丹参川芎嗪注射液联合长春西汀治疗颅内动脉瘤的临床研究[J].中西医结合心脑血管病杂志,2020,18(16):2730-2733. [2]赵大伟.中医中药辨证施治治疗脑血管痉挛性头痛临床分析[J].中国现代药物应用,2019,13(22):213-214. [3]Naderinabi B,Saberi A,Hashemi M,et al.Acupuncture and botulinum toxin A injection in the treatment of chronic migraine: A randomized controlled study[J].Caspian Journal of Internal Medicine,2017,8(3):196.[4]张桂贞.中医中药辨证施治治疗脑血管痉挛性头痛临床分析[J].中国实用医药,2018,13(13):108-109.[5]赵大伟.中医中药辨证施治治疗脑血管痉挛性头痛临床分析[J].中国现代药物应用,2019,13(22):213-214.[6]郭韵诗.尼莫地平联合小剂量阿司匹林治疗脑血管痉挛性头痛头晕[J].北方药学,2019,16(9):62-63.[7]任代平.盐酸氟桂利嗪用于脑血管痉挛性头痛患者治疗中的临床研究[J].影像研究与医学应用,2017,1(11):202-203. [8]夏悦晖.中医辨证治疗脑血管痉挛性头痛的临床比较观察[J].中国医药指南,2016,14(35):197-197,198.[9]Mizuma A,Nagata E,Yasuda T,et al.Botulinum toxin A is effective to treat tension-type headache caused by hemifacial spasm[J].J Clin Neurosci,2017(44):284-288.[10]吴东南,赵燕青,肖政,等.从风论治血管痉挛性心绞痛[J].河南中医,2020,40(3):354-356. [11]张胡磊.中医辨证后实施丹参注射液和川穹嗪注射液治疗偏头痛的疗效[J].北方药学,2018,15(9):92-93. [12]李华泉.中医中药辨证施治治疗脑血管痉挛性头痛的疗效观察[J].中国医药指南,2012,10(19):314-315.[13]曾凡鹏,胡光,罗丽梅,等.川芎嗪氨类衍生物合成方法工艺优化及抗血小板聚集活性评价[J].重庆理工大学学报(自然科学),2019,33(11):185-190.[14]陈玉兰.丹参川芎嗪注射液联合双联抗血小板治疗老年急性脑梗死的疗效观察[J].中西医结合心脑血管病杂志,2020,18(16):4.[15]曹丹.中医药辨证施治治疗脑血管痉挛性头痛临床分析[J].亚太传统医药,2017,13(2):125-126.

相似文献/References:

[1]郭建华.丹参川芎嗪联合阿托伐他汀钙治疗急性心肌梗死的疗效观察[J].医学信息,2018,31(01):145.[doi:10.3969/j.issn.1006-1959.2018.01.056]
　GUO Jian-hua.Effect of Salvia Miltiorrhiza Tetramethylpyrazine Combined with Atorvastatin Calcium in the Treatment of Acute Myocardial Infarction[J].Medical Information,2018,31(23):145.[doi:10.3969/j.issn.1006-1959.2018.01.056]
[2]赵东慧.丹参川芎嗪联合尼麦角林对后循环缺血性眩晕患者的效果及基底动脉血流速度的影响[J].医学信息,2022,35(21):58.[doi:10.3969/j.issn.1006-1959.2022.21.012]
　ZHAO Dong-hui.Effect of Danshen Ligustrazine Combined with Nicergoline on Patients with Posterior Circulation Ischemic Vertigo and Basilar Artery Blood Flow Velocity[J].Medical Information,2022,35(23):58.[doi:10.3969/j.issn.1006-1959.2022.21.012]
[3]贾丽华,李佳奇,郭欢迎.长春西汀注射剂小粒径不溶性微粒倍增现象及风险分析[J].医学信息,2023,36(20):89.[doi:10.3969/j.issn.1006-1959.2023.20.016]
　JIA Li-hua,LI Jia-qi,GUO Huan-ying.Multiplication Phenomenon and Risk Analysis of Small Particle Size Insoluble Particles in Vinpocetine Injection[J].Medical Information,2023,36(23):89.[doi:10.3969/j.issn.1006-1959.2023.20.016]

更新日期/Last Update: 1900-01-01