[1]刘华志,王春森.骨髓增生异常综合征突变基因与预后关系的研究现状[J].医学信息,2022,35(02):51-56.[doi:10.3969/j.issn.1006-1959.2022.02.013]
 LIU Hua-zhi,WANG Chun-sen.Research Status of Relationship Between Mutation Gene and Prognosis inMyelodysplastic Syndrome[J].Medical Information,2022,35(02):51-56.[doi:10.3969/j.issn.1006-1959.2022.02.013]
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骨髓增生异常综合征突变基因与预后关系的研究现状()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年02期
页码:
51-56
栏目:
综述
出版日期:
2022-01-15

文章信息/Info

Title:
Research Status of Relationship Between Mutation Gene and Prognosis inMyelodysplastic Syndrome
文章编号:
1006-1959(2022)02-0051-06
作者:
刘华志王春森
川北医学院,四川 南充 637000
Author(s):
LIU Hua-zhiWANG Chun-sen
North Sichuan Medical College,Nanchong 637000,Sichuan,China
关键词:
骨髓增生异常综合征驱动基因突变去甲基化骨髓移植
Keywords:
Myelodysplastic syndromeDrive gene mutationDemethylationBone marrow transplantation
分类号:
R733.3
DOI:
10.3969/j.issn.1006-1959.2022.02.013
文献标志码:
A
摘要:
骨髓增生异常综合症(MDS)是一种以造血功能不全和发育异常为特征的克隆性疾病。临床表现为外周血细胞的减少,可能演变为急性髓细胞性白血病(AML)。通过了解MDS患者的病理学参数与细胞遗传学信息,将有助于患者的诊断、预后判断及治疗。研究表明,基因突变对治疗结果也有影响,对预后的影响可导致患者预后风险分层的改善。某些基因突变自身就可能是治疗该病的潜在靶向目标,为新的靶标药物的研究与应用提供了可能。本文主要对MDS相关基因突变的致病机制及其对MDS预后的影响,基因突变与去甲基化药物治疗疗效的关系进行综述,以期为临床治疗MDS提供参考。
Abstract:
Myelodysplastic syndrome (MDS) is a clonal disease characterized by hematopoietic insufficiency and dysplasia. The clinical manifestation is a decrease in peripheral blood cells, which may evolve into acute myeloid leukemia (AML). By understanding the pathological parameters and cytogenetic information of patients with MDS, it will be helpful to the diagnosis, prognosis and treatment of patients. Recent studies have shown that gene mutations also have a key impact on treatment outcomes, and the impact on prognosis will lead to improved prognostic risk stratification. Certain gene mutations may themselves be potential targets for treatment, providing the feasibility for the research and application of new target drugs. This article reviews the pathogenic mechanism of MDS-related gene mutations, their influence on the prognosis of MDS, and their relationship with the efficacy of demethylation drugs.

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更新日期/Last Update: 1900-01-01