[1]张文旭,徐 绸.血必净联合连续肾脏替代治疗对感染性休克患者的疗效及对血液循环状态的影响[J].医学信息,2022,35(04):153-155.[doi:10.3969/j.issn.1006-1959.2022.04.040]
　ZHANG Wen-xu,XU Chou.Effect of Xuebijing Combined with Continuous Renal Replacement Therapy on Patientswith Septic Shock and its Effect on Blood Circulation[J].Medical Information,2022,35(04):153-155.[doi:10.3969/j.issn.1006-1959.2022.04.040]
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血必净联合连续肾脏替代治疗对感染性休克患者的疗效及对血液循环状态的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年04期
页码:
153-155
栏目:
药物与临床
出版日期:
2022-02-15

文章信息/Info

Title:
Effect of Xuebijing Combined with Continuous Renal Replacement Therapy on Patientswith Septic Shock and its Effect on Blood Circulation
文章编号:
1006-1959（2022）04-0153-03
作者:
张文旭; 徐 绸
解放军联勤保障部队第九八三医院重症医学科，天津 300142
Author(s):
ZHANG Wen-xu; XU Chou
Department of Critical Medicine,983 Hospital of PLA Joint Logistics Support Force,Tianjin 300142,China
关键词:
感染性休克; 肾脏替代治疗; 血必净; 血液循环
Keywords:
Septic shock; Renal replacement therapy; Xuebijing; Blood circulation
分类号:
R631+.4；R459.5
DOI:
10.3969/j.issn.1006-1959.2022.04.040
文献标志码:
A
摘要:
目的 探讨血必净联合连续肾脏替代治疗对感染性休克患者的疗效及对血液循环状态的影响。方法 选取2020年6月-2021年5月我院收治的感染性休克患者100例为研究对象，根据随机数字法为对照组53例和观察组47例。对照组单独给予连续肾脏替代治疗，观察组在给予连续肾脏替代治疗联合使用血必净治疗，比较两组并发症发生率、病死率、治疗前后急性生理与慢性健康评分Ⅱ（APACHE Ⅱ）、炎性因子[血清血乳酸（LA）、降钙素原（PCT）、Ｃ-反应蛋白（CRP）]表达水平、血液循环状态指标[活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）、纤维蛋白原（Fbg）]。结果 观察组并发症发生率、病死率及APACHEⅡ评分低于对照组（P＜0.05）；两组LA、PCT、CRP均低于治疗前，观察组低于对照组（P＜0.05）；两组APTT、TT均较治疗前降低，且观察组低于对照组（P＜0.05）；两组PT值均高于治疗前，观察组治疗后72 h的PT值低于对照组（P＜0.05）；对照组24、48 h的Fbg值与治疗前比较，差异无统计学意义（P＞0.05），但其72 h的Fbg值低于治疗前（P＜0.05）；观察组Fbg值低于治疗前，且不同时间点的Fbg值均低于对照组（P＜0.05）。结论 血必净联合连续肾脏替代治疗对感染性休克的疗效及对血液循环的改善显著优于单独给予肾脏替代治疗。
Abstract:
Objective To investigate the effect of Xuebijing combined with continuous renal replacement therapy on patients with septic shock and its effect on blood circulation.Methods A total of 100 patients with septic shock admitted to our hospital from June 2020 to May 2021 were selected as the study subjects. According to the random number method, 53 cases in the control group and 47 cases in the observation group were selected. The control group was treated with continuous renal replacement therapy alone, and the observation group was treated with continuous renal replacement therapy combined with Xuebijing. The incidence of complications, mortality, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) before and after treatment, the expression levels of inflammatory factors [serum lactic acid (LA), procalcitonin (PCT), C-reactive protein (CRP)] and blood circulation status indexes [activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen (Fbg)] were compared between the two groups.Results The incidence of complications, mortality and APACHE II score in the observation group were lower than those in the control group (P<0.05); LA, PCT and CRP in the two groups were lower than those before treatment, the observation group was lower than the control group(P<0.05). APTT and TT of the two groups were lower than those before treatment, and the observation group was lower than the control group(P<0.05); the PT values of the two groups were higher than those before treatment, the PT value of the observation group at 72 h after treatment was lower than that of the control group(P<0.05); there was no significant difference in the Fbg value at 24 h and 48 h in the control group before treatment (P>0.05), but the Fbg value at 72 h was lower than that before treatment (P<0.05); the Fbg value of the observation group was lower than that before treatment, and the Fbg value at different time points was lower than that of the control group(P<0.05).Conclusion The therapeutic effect and improvement of blood circulation in Xuebijing combined with continuous renal replacement therapy is superior to renal replacement therapy alone in the treatment of septic shock.

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更新日期/Last Update: 1900-01-01