[1]王跃慧.急性缺血性脑卒中的药物治疗[J].医学信息,2022,35(11):44-46,59.[doi:10.3969/j.issn.1006-1959.2022.11.013]
　WANG Yue-hui.Drug Treatment of Acute Ischemic Stroke[J].Medical Information,2022,35(11):44-46,59.[doi:10.3969/j.issn.1006-1959.2022.11.013]
点击复制

急性缺血性脑卒中的药物治疗()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年11期
页码:
44-46,59
栏目:
综述
出版日期:
2022-06-01

文章信息/Info

Title:
Drug Treatment of Acute Ischemic Stroke
文章编号:
1006-1959（2022）11-0044-04
作者:
王跃慧
（天津医科大学总医院滨海医院神经内科，天津 300480）
Author(s):
WANG Yue-hui
(Department of Neurology,Binhai Hospital,General Hospital of Tianjin Medical University,Tianjin 300480,China)
关键词:
急性缺血性脑卒中; 脑内动脉狭窄; 脑组织缺血; 药物治疗
Keywords:
Acute ischemic stroke; Cerebral artery stenosis; Cerebral ischemia; Drug therapy
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.11.013
文献标志码:
A
摘要:
脑卒中临床主要表现为脑组织缺血、缺氧，严重威胁患者的健康和生命安全。急性缺血性脑卒中具有较高的病死率、致残率，已经发展为社会公共卫生问题；即使临床给予及时有效的治疗，部分患者也伴有不同程度后遗症，临床预后较差。目前，临床对急性缺血性脑卒中的治疗缺乏特效方法。虽然药物治疗急性缺血性脑卒中可通过改善脑血液循环、保护神经等获得良好的治疗效果，但是不同药物疗效存在差异，如何科学合理选择治疗药物是当前研究热点。本文对急性缺血性脑卒中西药和中药治疗进展进行综述，以期为临床药物治疗急性缺血性脑卒中提供参考。
Abstract:
The clinical manifestations of stroke are mainly cerebral ischemia and hypoxia, which seriously threaten the health and life safety of patients. Acute ischemic stroke has a high mortality and disability rate, and has developed into a social public health problem. Even if given timely and effective treatment, some patients also have varying degrees of sequelae, patients with poor clinical prognosis. At present, the clinical treatment of acute ischemic stroke lacks specific methods. Although drug treatment for acute ischemic stroke can achieve good therapeutic effect by improving cerebral blood circulation and protecting nerves. However, there are differences in the efficacy of different drugs. How to select therapeutic drugs scientifically and reasonably is the current research hotspot. This article reviews the progress of western medicine and traditional Chinese medicine in the treatment of acute ischemic stroke, in order to provide reference for clinical drug treatment of acute ischemic stroke.

参考文献/References:

[1]邓珊,潘丽雅,阳洪,等.急性脑梗死患者静脉溶栓前进行阿托伐他汀预处理的疗效及安全性分析[J].中国医药导报,2017,14(19):55-58.[2]尹娟,刘本德.巴曲酶治疗早期急性缺血性脑卒中疗效分析[J].温州医科大学学报,2017,47(3):222-224.[3]Tang SC,Luo CJ,Zhang KH,et al.Effects of dl-3-nbutylphthalide on serum VEGF and bFGF levels in acute cerebral infarction[J].Eur Rev Med Pharmacol Sci,2017,21(19):4431-4436.[4]王广杰.大剂量瑞舒伐他汀联合重组人组织纤溶酶原激活剂治疗急性脑梗死临床疗效分析[J].国际医药卫生导报,2017,23(3):378-80.[5]Wang P,Miao CY.NAMPT as a therapeutic target against stroke[J].Trends Pharmacol Sci,2016,36(12):891-905.[6]彭斌,吴波.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.[7]王艳芳,魏占伟,曹阳,等.阿司匹林联合氯吡格雷双重抗血小板治疗对急性脑梗死合并脑微出血的影响分析[J].医药论坛杂志,2018,39(10):130-131[8]吴慧君,王立敏,李倩,等.双重抗血小板治疗对轻度急性缺血性脑卒中患者临床效果的影响[J].心脑血管病防治,2019,19(2):156-157,176.[9]Wang W,Jiang B,Sun H,et al.Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based survey of 480 687 adults[J].Circulation,2017,135(8):759-771.[10]张晓曼,王润清,李艾帆,等.丁苯酞软胶囊治疗缺血性脑卒中的临床疗效及安全性观察[J].中国实用神经疾病杂志,2010,13(17):81-83.[11]李虹,陈娜,陆连生,等.不同疗程的丁苯酞对急性缺血性脑卒中颈后及炎性因子的影响[J].河北医药,2017,39(1):130-132.[12]Xiong Z,Lu W,Zhu L,et al.Dl-3-n-butylphthalide treatment enhances hemodynamics and ameliorates memory deficits in rats with chronic cerebral hypoperfusion[J].Front Aging Neurosci,2017,9:238.[13]郭华,陈炅,索冬卫.瑞舒伐他汀对冠心病患者心功能、血脂水平、血液流变学水平及内皮功能的影响[J].中国生化药物杂志,2015,35(5):98-100,104.[14]罗孜贤.添加丁苯酞注射液治疗急性脑梗死的临床疗效评估研究[D].大连:大连医科大学,2016.[15]朱平华,邓同兴.静脉注射硫酸镁对急性缺血性脑卒中患者的临床疗效[J].中国药物经济学,2014,9(7):46-47.[16]郭子华.益气活血汤联合丁苯酞对缺血性脑卒中病人血清UA、ET-1、PTX-3、sICAM-1及神经功能的影响[J].中西医结合心脑血管病杂志,2018,16(8):1008-1011.[17]周曾,李美英,凤兆海,等.超早期静脉溶栓联合依达拉奉治疗急性脑梗死的临床效果观察[J].贵州医药,2017,41(11):1164-1165.[18]Johnston SC,Easton JD,Farrant M,et al.Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA[J].N Engl J Med,2018,379(3):215-225.[19]池卫明,林力.人尿激肽原酶对急性脑梗死患者CRP和血液流变学的影响[J].中国实用神经疾病杂志,2016,19(9):110-111.[20]王雷宇,吕丹丽,田常冬,等.化痰通腑汤治疗缺血性卒中急性期痰热腑实证患者的临床疗效及对神经功能缺损和生活质量的影响[J].河北中医,2021,43(11):1832-1835.[21]万海同,别晓东,姚政,等.养阴益气活血方治疗气阴两虚证、瘀血阻络证缺血性中风疗效观察[J].中国中西医结合杂志,2015,35(3):281-286.[22]范崇桂,付国惠,闪海霞,等.丹参多酚酸对急性缺血性脑卒中患者脑灌注的改善作用及其作用机制[J].世界中西医结合杂志,2020,15(5):939-942.

相似文献/References:

[1]王珊珊.国内丁苯肽治疗急性缺血性脑卒中机制的应用研究[J].医学信息,2019,32(09):58.[doi:10.3969/j.issn.1006-1959.2019.09.019]
　WANG Shan-shan.Study on the Application of Domestic Butyl Phenyl Peptide in the Treatment of Acute Ischemic Stroke[J].Medical Information,2019,32(11):58.[doi:10.3969/j.issn.1006-1959.2019.09.019]
[2]宋贵军.急性缺血性脑卒中静脉溶栓治疗[J].医学信息,2020,33(17):47.[doi:10.3969/j.issn.1006-1959.2020.17.014]
　SONG Gui-jun.Intravenous Thrombolytic Therapy for Acute Ischemic Stroke[J].Medical Information,2020,33(11):47.[doi:10.3969/j.issn.1006-1959.2020.17.014]
[3]王 楠.替罗非班对急性缺血性脑卒中患者新发脑微出血的影响[J].医学信息,2021,34(14):114.[doi:10.3969/j.issn.1006-1959.2021.14.030]
　WANG Nan.The Effect of Tirofiban on New Cerebral Microhemorrhage in Patients with Acute Ischemic Stroke[J].Medical Information,2021,34(11):114.[doi:10.3969/j.issn.1006-1959.2021.14.030]
[4]王 楠.肠内营养联合双歧杆菌三联活菌对神经介入治疗后急性缺血性脑卒中患者二胺氧化酶及营养指标的影响[J].医学信息,2021,34(15):169.[doi:10.3969/j.issn.1006-1959.2021.15.047]
　WANG Nan.The Effect of Enteral Nutrition Combined with Live Bifidobacterium Triple Bacteria on Diamine Oxidase and Nutritional Indicators in Patients with Acute Ischemic Stroke After Neurointerventional Therapy[J].Medical Information,2021,34(11):169.[doi:10.3969/j.issn.1006-1959.2021.15.047]
[5]钮 静,权文娟,赵春洪,等.优化静脉溶栓流程在改善急性缺血性脑卒中患者即时疗效的应用[J].医学信息,2021,34(20):139.[doi:10.3969/j.issn.1006-1959.2021.20.036]
　NIU Jing,QUAN Wen-juan,ZHAO Chun-hong,et al.Application of Optimizing Intravenous Thrombolysis Process in Improving Immediate Efficacy ofPatients with Acute Ischemic Stroke[J].Medical Information,2021,34(11):139.[doi:10.3969/j.issn.1006-1959.2021.20.036]
[6]贾红芳,董林森,李文芳.尤瑞克林联合丁苯酞治疗急性缺血性脑卒中的效果及对神经功能的影响[J].医学信息,2021,34(22):139.[doi:10.3969/j.issn.1006-1959.2021.22.043]
　JIA Hong-fang,DONG Lin-sen,LI Wen-fang.Effect of Urinary Kallidinogenase Combined with Butylphthalide on Acute Ischemic Stroke and its Effect on Neurological Function[J].Medical Information,2021,34(11):139.[doi:10.3969/j.issn.1006-1959.2021.22.043]
[7]郑钰蓉,殷 梅,罗 悯.急性缺血性脑卒中伴发脑心综合征的临床研究[J].医学信息,2022,35(17):156.[doi:10.3969/j.issn.1006-1959.2022.17.043]
　ZHENG Yu-rong,YIN Mei,LUO Min.Clinical Study of Acute Ischemic Stroke with Cerebrocardiac Syndrome[J].Medical Information,2022,35(11):156.[doi:10.3969/j.issn.1006-1959.2022.17.043]
[8]褚春沐.血浆纤维蛋白原和D-二聚体在急性缺血性脑卒中治疗中的应用价值[J].医学信息,2022,35(21):101.[doi:10.3969/j.issn.1006-1959.2022.21.024]
　CHU Chun-mu.The Application Value of Plasma Fibrinogen and D-dimer in the Treatment of Acute Ischemic Stroke[J].Medical Information,2022,35(11):101.[doi:10.3969/j.issn.1006-1959.2022.21.024]
[9]罗贤云.阿托伐他汀联合双抗治疗对急性缺血性脑卒中患者血脂、神经功能及预后的影响[J].医学信息,2022,35(23):133.[doi:10.3969/j.issn.1006-1959.2022.23.027]
　LUO Xian-yun.Effect of Atorvastatin Combined with Double Antibody Therapy on Blood Lipid, Neurological Function and Prognosis in Patients with Acute Ischemic Stroke[J].Medical Information,2022,35(11):133.[doi:10.3969/j.issn.1006-1959.2022.23.027]
[10]赵东慧,王 楠,杨思远.不同阿替普酶溶栓时间对急性缺血性脑卒中患者神经功能及不良反应的影响[J].医学信息,2023,36(14):108.[doi:10.3969/j.issn.1006-1959.2023.14.021]
　ZHAO Dong-hui,WANG Nan,YANG Si-yuan.Effect of Different Alteplase Thrombolysis Time on Neurological Function and Adverse Reactions in Patients with Acute Ischemic Stroke[J].Medical Information,2023,36(11):108.[doi:10.3969/j.issn.1006-1959.2023.14.021]

更新日期/Last Update: 1900-01-01