[1]王 杰.阿加曲班对脑梗塞急性期患者血液流变指标及APTT、PT的影响[J].医学信息,2022,35(22):130-132.[doi:10.3969/j.issn.1006-1959.2022.22.030]
　WANG Jie.Effects of Argatroban on Hemorheology Indexes, APTT and PT in Patients with Acute Cerebral Infarction[J].Journal of Medical Information,2022,35(22):130-132.[doi:10.3969/j.issn.1006-1959.2022.22.030]
点击复制

阿加曲班对脑梗塞急性期患者血液流变指标及APTT、PT的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年22期
页码:
130-132
栏目:
药物与临床
出版日期:
2022-11-15

文章信息/Info

Title:
Effects of Argatroban on Hemorheology Indexes, APTT and PT in Patients with Acute Cerebral Infarction
文章编号:
1006-1959（2022）22-0130-03
作者:
王 杰
（佳木斯市中心医院康复科，黑龙江 佳木斯 154002）
Author(s):
WANG Jie
(Department of Rehabilitation,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
脑梗塞; 阿加曲班; 活化部分凝血活酶时间; 凝血酶原时间; 血液流变
Keywords:
Cerebral infarction; Agathuban; Activated partial thrombin time; Prothrombin time; The blood rheological
分类号:
R741.05
DOI:
10.3969/j.issn.1006-1959.2022.22.030
文献标志码:
A
摘要:
目的 探讨阿加曲班对脑梗塞急性期患者的血液流变指标、活化部分凝血活酶时间（APTT）和凝血酶原时间（PT）的影响。方法 选取2019年2月-2021年10月我院收治的脑梗塞急性期患者40例，采用随机数字表法分为对照组与治疗组，各20例。对照组予以常规治疗，治疗组在对照组基础上予以阿加曲班治疗，疗程为1个月。比较两组临床疗效、血液流变指标（全血高切黏度和低切黏度、血浆黏度、红细胞压积）和凝血功能指标[APTT、PT、纤维蛋白原（FIB）和血小板计数（PLT）]。结果 治疗组临床疗效高于对照组（P＜0.05）；治疗组治疗后全血高切黏度和低切黏度、血浆黏度、红细胞压积水平均低于对照组（P＜0.05）；治疗组治疗后FIB、PLT水平低于对照组，APTT、PT高于对照组（P＜0.05）。结论 将阿加曲班应用于治疗脑梗塞急性期患者，可降低患者各项血液流变指标水平、FIB和PLT水平，并提高APTT、PT指标，改善患者凝血功能和血液流变指标。
Abstract:
Objective To investigate the effects of argatroban on hemorheology, activated partial thromboplastin time (APTT) and prothrombin time (PT) in patients with acute cerebral infarction.Methods Forty patients with acute cerebral infarction admitted to our hospital from February 2019 to October 2021 were selected and divided into a control group and a treatment group by random number table method, with 20 cases in each group. The control group was given routine treatment, and the treatment group was treated with argatroban on the basis of the control group for 1 month. The clinical efficacy, blood rheological indexes (whole blood high shear viscosity and low shear viscosity, plasma viscosity, hematocrit) and coagulation function indexes [APTT, PT, fibrinogen (FIB) and platelet count (PLT)] were compared between the two groups.Results The clinical efficacy of the treatment group was higher than that of the control group (P<0.05). The whole blood high shear viscosity, low shear viscosity, plasma viscosity and hematocrit in the treatment group were lower than those in the control group (P<0.05). After treatment, FIB and PLT levels in the treatment group were lower than those in the control group, APTT and PT were higher than those in the control group (P<0.05).Conclusion The application of argatroban treatment can reduce the levels of hemorheology indexes, FIB and PLT in patients with acute cerebral infarction, and increase APTT and PT indexes, improve coagulation function and hemorheology indexes.

参考文献/References:

[1]刘杰,任晓艳,张昊.缺血性脑卒中急性期认知障碍危险因素及其与Lp-PLA2、VILIP-1的相关性[J].中西医结合心脑血管病杂志,2021,19(16):2833-2837.[2]Herpich F,Rincon F.Management of Acute Ischemic Stroke[J].Crit Care Med,2020,48(11):1654-1663.[3]郑伟城,肖卫民,石铸.缺血性脑卒中急性期的抗血小板治疗[J].中华脑血管病杂志,2013,7(3):142-147.[4]Maida CD,Norrito RL,Daidone M,et al.Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches[J].Int J Mol Sci,2020,21(18):6454.[5]李博,杨利孙,杨瑞林.血管内介入疗法对急性缺血性脑卒中患者的临床疗效及对血液流变学和炎性因子的影响[J].贵州医药,2021,45(2):210-211.[6]Paul S,Candelario-Jalil E.Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies[J].Exp Neurol,2021,335:113518.[7]宋贺,刘存华,李健.血管内介入疗法治疗急性缺血性脑卒中患者的疗效及对血液流变学和炎性因子的影响[J].河北医药,2019,41(23):3609-3612.[8]孔雪丽.氯吡格雷结合阿托伐他汀治疗脑梗死疗效观察[J].云南医药,2021,42(4):391-392.[9]Bao L,Zhang S,Gong X,et al.Trousseau Syndrome Related Cerebral Infarction: Clinical Manifestations, Laboratory Findings and Radiological Features[J].J Stroke Cerebrovasc Dis,2020,29(9):104891.[10]Ni T,Fu Y,Zhou W,et al.Carotid plaques and neurological impairment in patients with acute cerebral infarction[J].PLoS One,2020,15(1):e0226961.[11]Yuan Q,Yu L,Wang F.Efficacy of using thromboelastography to detect coagulation function and platelet function in patients with acute cerebral infarction[J].Acta Neurol Belg,2021,121(6):1661-1667.[12]Schuhmann MK,Stoll G,Bieber M,et al.CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke[J].Circ Res,2020,127(8):1023-1035.[13]Wang N,Liu L,Jiang X,et al.Acute multiple cerebral infarction combined with cerebral microhemorrhage in Polycythemia vera: A case report[J].Exp Ther Med,2019,18(4):2949-2955.[14]Liang Y,Wu J,Liu J,et al.The Clinical Implications of Thrombelastography in the Diagnosis of Acute Cerebral Infarction[J].Clin Lab,2018,64(1):147-152.[15]Beyer JT,Lind SE,Fisher S,et al.Evaluation of intravenous direct thrombin inhibitor monitoring tests: Correlation with plasma concentrations and clinical outcomes in hospitalized patients[J].J Thromb Thrombolysis,2020,49(2):259-267.[16]Aliter KF,Al-Horani RA.Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19[J].Cardiovasc Drugs Ther,2021,35(2):195-203.[17]Sun Z,Lan X,Li S,et al.Comparisons of argatroban to lepirudin and bivalirudin in the treatment of heparin-induced thrombocytopenia: a systematic review and meta-analysis[J].Int J Hematol,2017,106(4):476-483.[18]宋翠云,刘扬,侯丽艳.阿加曲班抗凝治疗进展性脑梗死的效果及安全性分析[J].中西医结合心脑血管病杂志,2021,19(2):336-338.[19]Liu S,Liu P,Wang P,et al.Argatroban Increased the Basal Vein Drainage and Improved Outcomes in Acute Paraventricular Ischemic Stroke Patients[J].Med Sci Monit,2020,26:e924593.[20]Wert L,Hanke JS,Dogan G,et al.Argatroban administration as therapy for thrombosis in patients with continuous-flow ventricular assist devices[J].J Thorac Dis,2018,10(Suppl 15):S1720-S1727.

相似文献/References:

[1]冯 湧.新一代抗凝血药阿加曲班的临床应用进展[J].医学信息,2018,31(02):43.[doi:10.3969/j.issn.1006-1959.2018.02.015]
　FENG Yong.Progress in Clinical Application of the New Generation Anticoagulant Agatripine[J].Journal of Medical Information,2018,31(22):43.[doi:10.3969/j.issn.1006-1959.2018.02.015]
[2]胡少勇,姜浩斌,张景硕,等.3例动脉瘤夹闭术后脑梗塞的手术治疗报告[J].医学信息,2018,31(07):189.[doi:10.3969/j.issn.1006-1959.2018.07.068]
　HU Shao-yong,JIANG Hao-bin,ZHANG Jing-shuo,et al.Surgical Treatment of 3 Cases of Cerebral Infarction after Aneurysm Clipping[J].Journal of Medical Information,2018,31(22):189.[doi:10.3969/j.issn.1006-1959.2018.07.068]
[3]陈建新.阿加曲班注射液治疗急性脑梗死的疗效及对血清VEGF、GLUT-1水平的影响[J].医学信息,2018,31(19):5.[doi:10.3969/j.issn.1006-1959.2018.19.002]
　CHEN Jian-xin.Effect of Argatroban Injection on Acute Cerebral Infarction and Its Effect on Serum VEGF and GLUT-1 Levels[J].Journal of Medical Information,2018,31(22):5.[doi:10.3969/j.issn.1006-1959.2018.19.002]
[4]钱朝庆,刘 淼,王家平,等.肾病综合征合并肾静脉血栓应用阿加曲班疗效评价[J].医学信息,2018,31(21):135.[doi:10.3969/j.issn.1006-1959.2018.21.038]
　QIAN Chao-qing,LIU Miao,WANG Jia-ping,et al.Clinical Efficacy Evaluation of Argatroban in Nephrotic Syndrome with Renal Vein Thrombosis[J].Journal of Medical Information,2018,31(22):135.[doi:10.3969/j.issn.1006-1959.2018.21.038]
[5]倪 明,张平平,刘明法.滨海新区脑梗塞发病情况及影响因素分析[J].医学信息,2019,32(20):124.[doi:10.3969/j.issn.1006-1959.2019.20.038]
　NI Ming,ZHANG Ping-ping,LIU Ming-fa.Analysis of Incidence and Influencing Factors of Cerebral Infarction in Binhai New Area[J].Journal of Medical Information,2019,32(22):124.[doi:10.3969/j.issn.1006-1959.2019.20.038]
[6]王 浩.DWI对超急性期脑梗塞的诊断价值[J].医学信息,2020,33(14):172.[doi:10.3969/j.issn.1006-1959.2020.14.057]
　WANG Hao.The Diagnostic Value of DWI in Hyperacute Cerebral Infarction[J].Journal of Medical Information,2020,33(22):172.[doi:10.3969/j.issn.1006-1959.2020.14.057]
[7]王桂丽.责任制护理对序贯抗凝治疗老年脑梗塞患者生存质量的影响[J].医学信息,2020,33(16):95.[doi:10.3969/j.issn.1006-1959.2020.16.028]
　WANG Gui-li.The Effect of Responsible Nursing on the Quality of Life of Elderly Patients with Cerebral Infarction Treated by Sequential Anticoagulation[J].Journal of Medical Information,2020,33(22):95.[doi:10.3969/j.issn.1006-1959.2020.16.028]
[8]徐 萌,潘琳娜,季 莹.糖尿病合并高血压患者脑微出血和脑梗塞的关系[J].医学信息,2020,33(18):83.[doi:10.3969/j.issn.1006-1959.2020.18.025]
　XU Meng,PAN Lin-na,JI Ying.The Relationship Between Cerebral Microbleeds and Cerebral Infarction in Diabetic Patients with Hypertension[J].Journal of Medical Information,2020,33(22):83.[doi:10.3969/j.issn.1006-1959.2020.18.025]
[9]陈亚楠.急性脑梗塞患者TNF-α、IL-6、CRP、MDA 和SOD水平及其临床意义[J].医学信息,2020,33(24):107.[doi:10.3969/j.issn.1006-1959.2020.24.029]
　CHEN Ya-nan.The Levels of TNF-α,IL-6,CRP,MDA and SOD in Patients with Acute Cerebral Infarction and Their Clinical Significance[J].Journal of Medical Information,2020,33(22):107.[doi:10.3969/j.issn.1006-1959.2020.24.029]
[10]胡卫华.三向同性扩散加权成像与表观扩散系数图在不同时期脑梗塞诊断、转归和分期中的应用价值[J].医学信息,2021,34(21):94.[doi:10.3969/j.issn.1006-1959.2021.21.024]
　HU Wei-hua.Application Value of Three-dimensional Isotropic Diffusion Weighted Imaging and Apparent Diffusion Coefficient Map in the Diagnosis, Prognosis and Staging of Cerebral Infarction in Different Periods[J].Journal of Medical Information,2021,34(22):94.[doi:10.3969/j.issn.1006-1959.2021.21.024]

更新日期/Last Update: 1900-01-01