[1]王 霞,周 华.血清胱抑素C、凝血功能检测在急性脑梗死患者中的应用价值[J].医学信息,2022,35(22):148-150.[doi:10.3969/j.issn.1006-1959.2022.22.036]
　WANG Xia,ZHOU Hua.Application Value of Detection of Serum Cystatin C and Coagulation Function in Patients with Acute Cerebral Infarction[J].Journal of Medical Information,2022,35(22):148-150.[doi:10.3969/j.issn.1006-1959.2022.22.036]
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血清胱抑素C、凝血功能检测在急性脑梗死患者中的应用价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年22期
页码:
148-150
栏目:
诊疗技术
出版日期:
2022-11-15

文章信息/Info

Title:
Application Value of Detection of Serum Cystatin C and Coagulation Function in Patients with Acute Cerebral Infarction
文章编号:
1006-1959（2022）22-0148-03
作者:
王 霞; 周 华
（宜兴市第二人民医院检验科，江苏 宜兴 214221）
Author(s):
WANG Xia; ZHOU Hua
(Department of Laboratory,Yixing No.2 People’s Hospital,Yixing 214221,Jiangsu,China)
关键词:
急性脑梗死; 血清胱抑素C; 凝血功能; 血浆纤维蛋白; 凝血酶原时间; 抗血凝酶-Ⅲ
Keywords:
Acute cerebral infarction; Serum cystatin C; Coagulation function; Plasma fibrin; Prothrombin time; Anticoagulant-Ⅲ
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.22.036
文献标志码:
A
摘要:
目的 探究血清胱抑素C（CysC）与凝血功能检测在急性脑梗死（ACI）患者中的价值。方法 选取宜兴市第二人民医院2019年1月-2021年10月收治的83例ACI患者作为观察组，另选同期83名体检健康者为对照组，比较两组血清CysC水平及凝血功能指标[血浆纤维蛋白（FIB）、凝血酶原时间（PT）、抗血凝酶-Ⅲ（AT-Ⅲ）]，比较观察组不同TOAST分型与改良Rankin量表（mRS）评分患者的CysC水平及凝血功能指标。结果 观察组CysC、FIB水平高于对照组，PT、AT-Ⅲ低于对照组（P＜0.05）；不同TOAST分型患者的CysC、FIB、PT、AT-Ⅲ水平比较，差异有统计学意义（P＜0.05），其中CysC、FIB水平由高到低依次为心源性脑栓塞型（CE）＞大动脉粥样硬化型（LAA）＞小血管闭塞型脑梗死（SAO），PT、AT-Ⅲ由高到低依次为SAO＞LAA＞CE；mRS评分＞2分的患者CysC、FIB水平高于mRS评分≤2分的患者，PT、AT-Ⅲ水平低于mRS评分≤2分的患者（P＜0.05）。结论 血清CysC与凝血功能指标可为ACI诊断提供可靠的依据，且在ACI分型及预后判断中也具有重要作用。
Abstract:
Objective To explore the value of serum cystatin C (CysC) and coagulation function in patients with acute cerebral infarction (ACI).Methods A total of 83 patients with ACI admitted to the Yixing No.2 People’s Hospital from January 2019 to October 2021 were selected as the observation group, and 83 healthy subjects were selected as the control group. The serum CysC level and coagulation function indexes [plasma fibrinogen (FIB), prothrombin time (PT), antithrombin-Ⅲ(AT-Ⅲ)] were compared between the two groups. The CysC level and coagulation function indexes of patients with different TOAST classifications and modified Rankin scale (mRS) scores in the observation group were compared.Results The levels of CysC and FIB in the observation group were higher than those in the control group, and PT and AT-Ⅲ were lower than those in the control group (P<0.05). The levels of CysC, FIB, PT and AT-III in patients with different TOAST types were statistically significant (P<0.05), while the levels of CysC and FIB from high to low were cardiogenic cerebral embolism (CE)>large artery atherosclerosis (LAA)>small vessel occlusion cerebral infarction (SAO), and PT and AT-Ⅲ from high to low were SAO>LAA>CE. The levels of CysC and FIB in patients with mRS score>2 were higher than those in patients with mRS score≤2, and the levels of PT and AT-Ⅲ were lower than those in patients with mRS score≤2 (P<0.05).Conclusion Serum CysC and coagulation function indicators can provide a reliable basis for the diagnosis of ACI, and also play an important role in the classification and prognosis of ACI.

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更新日期/Last Update: 1900-01-01