[1]曾文宏,叶芳芳,周志明.哌拉西林钠他唑巴坦钠联合左氧氟沙星治疗慢性支气管炎的临床疗效及安全性观察[J].医学信息,2022,35(23):140-142.[doi:10.3969/j.issn.1006-1959.2022.23.029]
　ZENG Wen-hong,YE Fang-fang,ZHOU Zhi-ming.Observation on Clinical Efficacy and Safety of Piperacillin Sodium and Tazobactam Sodium Combined with Levofloxacin in the Treatment of Chronic Bronchitis[J].Journal of Medical Information,2022,35(23):140-142.[doi:10.3969/j.issn.1006-1959.2022.23.029]
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哌拉西林钠他唑巴坦钠联合左氧氟沙星治疗慢性支气管炎的临床疗效及安全性观察()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年23期
页码:
140-142
栏目:
药物与临床
出版日期:
2022-12-01

文章信息/Info

Title:
Observation on Clinical Efficacy and Safety of Piperacillin Sodium and Tazobactam Sodium Combined with Levofloxacin in the Treatment of Chronic Bronchitis
文章编号:
1006-1959（2022）23-0140-04
作者:
曾文宏; 叶芳芳; 周志明
（吉水县人民医院呼吸内科，江西 吉水 331600）
Author(s):
ZENG Wen-hong; YE Fang-fang; ZHOU Zhi-ming
(Department of Respiratory,Jishui County People’s Hospital,Jishui 331600,Jiangxi,China)
关键词:
慢性支气管炎; 左氧氟沙星; 哌拉西林钠他唑巴坦钠; 肺功能
Keywords:
Chronic bronchitis; Levofloxacin; Piperacillin sodium and tazobactam sodium; Pulmonary function
分类号:
R562.2+1
DOI:
10.3969/j.issn.1006-1959.2022.23.029
文献标志码:
A
摘要:
目的 观察哌拉西林钠他唑巴坦钠（PS/TS）联合左氧氟沙星治疗慢性支气管炎（CB）的临床疗效及安全性。方法 选取2019年1月-2021年5月吉水县人民医院收治的68例CB患者为研究对象，按照随机数字表法分为对照组与观察组，各34例。对照组给予PS/TS治疗，观察组在其基础上加用左氧氟沙星治疗，比较两组临床疗效、症状缓解时间、肺功能[呼气流量峰值（PEF）、最大通气量（MVV）、第1 s用力呼气量（FEV1）]、实验室指标[白细胞（WBC）、中性粒细胞百分比（NEUT）、C反应蛋白（CRP）]、不良反应。结果 观察组治疗有效率较对照组高（P＜0.05）；观察组症状（咳嗽、咳痰、喘息）缓解时间短于对照组（P＜0.05）；两组治疗后PEF、MVV、FEV1均有所升高，且观察组较对照组高（P＜0.05）；两组治疗后WBC、NEUT、CRP水平均有所下降，且观察组较对照组低（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 PS/TS联合左氧氟沙星治疗CB效果确切，可缩短症状缓解时间，改善患者肺功能及实验室指标，且不良反应少。
Abstract:
Objective To observe the clinical efficacy and safety of piperacillin sodium and tazobactam sodium (PS/TS) combined with levofloxacin in the treatment of chronic bronchitis (CB).Methods A total of 68 CB patients admitted to Jishui County People’s Hospital from January 2019 to May 2021 were selected as the research objects and divided into control group and observation group according to the random number table method, with 34 cases in each group. The control group was treated with PS/TS, and the observation group was treated with levofloxacin on the basis of the control group. The clinical efficacy, symptom relief time, pulmonary function [peak expiratory flow (PEF), maximum ventilation (MVV), forced expiratory volume in one second (FEV1)], laboratory indexes [white blood cell (WBC), neutrophil percentage (NEUT), C-reactive protein (CRP)] and adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group (P<0.05). The remission time of symptoms (cough, sputum, wheezing) in the observation group was shorter than that in the control group (P<0.05). PEF, MVV and FEV1 increased in both groups after treatment, and the observation group was higher than the control group (P<0.05). The levels of WBC, NEUT and CRP in the two groups decreased after treatment, and the levels in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion PS/TS combined with levofloxacin is effective in the treatment of CB, which can shorten the time of symptom relief, improve the lung function and laboratory indexes of patients, and has fewer adverse reactions.

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更新日期/Last Update: 1900-01-01