[1]柳旭丽,徐 红,刘金香,等.TIPE2、TNF-α、IL-1β在高血压脑出血患者的表达和意义[J].医学信息,2023,36(21):94-97.[doi:10.3969/j.issn.1006-1959.2023.21.021]
　LIU Xu-li,XU Hong,LIU Jin-xiang,et al.Expression and Significance of TIPE2, TNF-α and IL-1β in Patients with Hypertensive Cerebral Hemorrhage[J].Journal of Medical Information,2023,36(21):94-97.[doi:10.3969/j.issn.1006-1959.2023.21.021]
点击复制

TIPE2、TNF-α、IL-1β在高血压脑出血患者的表达和意义()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年21期
页码:
94-97
栏目:
论著
出版日期:
2023-11-01

文章信息/Info

Title:
Expression and Significance of TIPE2, TNF-α and IL-1β in Patients with Hypertensive Cerebral Hemorrhage
文章编号:
1006-1959（2023）21-0094-04
作者:
柳旭丽; 徐 红; 刘金香; 等
（1.昌邑市人民医院特检科，山东 昌邑 261300；2.昌邑市人民医院检验科，山东 昌邑 2613003.潍坊市人民医院创伤骨科，山东 潍坊 261041）
Author(s):
LIU Xu-li; XU Hong; LIU Jin-xiang; et al.
(1.Department of Special Inspection,Changyi People’s Hospital,Changyi 261300,Shandong,China;2.Department of Clinical Laboratory,Changyi People’s Hospital,Changyi 261300,Shandong,China;3.Department of Orthopedics and Trauma,Weifang People’s Hospital,Weifang 261041,Shandong,China)
关键词:
高血压脑出血; TIPE2; TNF-α; IL-1β
Keywords:
Hypertensive cerebral hemorrhage; TIPE2; TNF- α; IL-1β
分类号:
R741
DOI:
10.3969/j.issn.1006-1959.2023.21.021
文献标志码:
A
摘要:
目的 观察高血压患者血清TIPE2、TNF-α、IL-1β的表达水平，并探讨其对高血压脑出血患者的影响。方法 选取2017年1月-2020年12月在昌邑市人民医院确诊的高血压脑出血患者45例作为观察组，另选取同期45例健康人作为对照组。ELISA试验检测两组血清TIPE2、TNF-α、IL-1β的表达量，分析TIPE2、TNF-α、IL-1β与临床指标的关系及TIPE2与TNF-α、IL-1β的相关性。结果 观察组血清TIPE2低于对照组，TNF-α、IL-1β高于对照组（P＜0.05）；TIPE2、TNF-α、IL-1β与年龄、性别均无关（P＞0.05）。TGF-β1与TNF-α（r=-0.368）、IL-1β（r=-0.338）呈负相关。结论 高血压脑出血患者血清中TIPE2的表达较健康人降低，TNF-α、IL-1β的表达升高，且TIPE2的表达与TNF-α、IL-1β密切相关。
Abstract:
Objective To observe the expression levels of serum TIPE2, TNF-α and IL-1β in patients with hypertension, and to explore their effects on patients with hypertensive cerebral hemorrhage.Methods A total of 45 patients with hypertensive cerebral hemorrhage diagnosed in Changyi People’s Hospital from January 2017 to December 2020 were selected as the observation group, and 45 healthy people in the same period were selected as the control group. The expression levels of serum TIPE2, TNF-α and IL-1β in the two groups were detected by ELISA test. The relationship between TIPE2, TNF-α, IL-1β and clinical indicators and the correlation between TIPE2 and TNF-α, IL-1β were analyzed.Results Serum TIPE2 in the observation group was lower than that in the control group, and TNF-α and IL-1β were higher than those in the control group (P<0.05). TIPE2, TNF-α and IL-1β were not related to age and gender (P>0.05). TGF-β1 was negatively correlated with TNF-α (r=-0.368) and IL-1β (r=-0.338).Conclusion The expression of serum TIPE2 in patients with hypertensive cerebral hemorrhage is lower than that of healthy people, and the expression of TNF-α and IL-1β is increased. While, the expression of TIPE2 is closely related to TNF-α and IL-1β.

参考文献/References:

[1]王增武.中国高血压流行和防治现状[J].中国心血管病研究,2022,20(8):673-678. [2]徐婷玲,周脉耕,刘江美,等.1990年与2019年中国居民归因于高血压的死亡负担分析[J].中国慢性病预防与控制,2022,30(5):327-331,335.[3]石代乐,高继英,高晓玲,等.血清eNOS、sIL-2R、NF-κB在高血压脑出血术后颅内感染预测中的价值及与预后关联性[J].中国老年学杂志,2022,42(7):1553-1557. [4]薛龙转,任光辉,李武雄.微创颅内血肿清除术与开颅手术治疗高血压脑出血患者的手术指标及预后对比[J].包头医学,2022,46(3):34-36.[5]Li W,Li Y,Guan Y,et al.TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis[J].Autophagy,2021,17(6):1410-1425. [6]Chakraborty S,Galla S,Cheng X,et al.Salt-Responsive Metabolite,β-Hydroxybutyrate,Attenuates Hypertension[J].Cell Rep,2018,25(3):677-689.e4. [7]Chua J,Le TT,Tan B,et al.Choriocapillaris microvasculature dysfunction in systemic hypertension[J].Sci Rep,2021,11(1):4603. [8]庞翀,陈群娟.缬沙坦联合富马酸比索洛尔对老年高血压心脏病患者相关生化指标、炎症因子及氧化应激水平的影响[J].中国老年学杂志,2021,41(4):673-676.[9]李娜,张岩,贾营.NF-κB/RBP4信号通路与高血压患者炎症因子变化的相关性[J].临床和实验医学杂志,2021,20(24):2592-2595. [10]Garcia Fragas M,Gast?觔o Davanzo G.Cross-Talk between TNF-α and Angiotensin II in the Neural Control of Hypertension[J].J Neurosci,2021,41(36):7512-7513. [11]Rong W,Liu C,Li X,et al.Caspase-8 Promotes Pulmonary Hypertension by Activating Macrophage-Associated Inflammation and IL-1β (Interleukin 1β) Production[J].Arterioscler Thromb Vasc Biol,2022,42(5):613-631.[12]Zhai Z,Yang F,Xu W,et al.Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor-Induced Caspase 3/Gasdermin E-Mediated Pyroptosis[J].Arthritis Rheumatol,2022,74(3):427-440. [13]Baker MC,Sheth K,Witteles R,et al.TNF-alpha inhibition for the treatment of cardiac sarcoidosis[J].Semin Arthritis Rheum,2020,50(3):546-552. [14]Chien SY,Tsai CH,Liu SC,et al.Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis[J].Cells,2020,9(4):927. [15]杨雪娇,吴艳飞.HPV感染及IL-1β、EGFR单核苷酸多态性与非吸烟女性肺癌的相关性研究[J].公共卫生与预防医学,2022,33(6):115-118.[16]刘莉,戈春城,黄婧.慢性牙周炎患者龈沟液中IL-35、IL-1β及IFN-γ的表达与临床意义[J].分子诊断与治疗杂志,2022,14(9):1628-1631. [17]杜娟,李智慧,郭建华,等.高血压脑出血患者术后预后不良危险因素分析[J].中国医刊,2022,57(9):981-984. [18]姜拓之,李培武.中药治疗脑出血后脑损伤病理机制的研究进展[J].生物医学转化,2022,3(3):57-63. [19]李丹,徐沙丽,周志林.基于p38 MAPK/Drosha信号通路探讨脑出血患者继发性脑损伤及神经细胞凋亡的机制[J].华南国防医学杂志,2021,35(11):786-791,795. [20]蒋丽娜,张红,翟嘉怡,等.TIPE2及其在炎症相关疾病中的作用[J].中国免疫学杂志,2019,35(19):2410-2413,2418.[21]马乔炎,张平.冠心病病人血浆中相关炎性因子水平及其与TIPE2的关系研究[J].实用老年医学,2019,33(6):569-572.

相似文献/References:

[1]刘伟兰,罗丽珍.围手术护理干预在高血压脑出血小骨窗开颅血肿清除术中的效果观察[J].医学信息,2018,31(02):166.[doi:10.3969/j.issn.1006-1959.2018.02.064]
　LIU Wei-lan,LUO Li-zhen.Effect of Perioperative Nursing Intervention on Craniotomy Hematoma Clearance of Small Bone Window in Hypertensive Intracerebral Hemorrhage[J].Journal of Medical Information,2018,31(21):166.[doi:10.3969/j.issn.1006-1959.2018.02.064]
[2]韩 冬.小骨窗血肿清除术与微创穿刺血肿引流术治疗 高血压脑出血的效果比较[J].医学信息,2018,31(05):105.[doi:10.3969/j.issn.1006-1959.2018.05.035]
　HAN Dong.Comparison of Small Window Hematoma Clearance and Minimally Invasive Hematoma Drainage in the Treatment of Hypertensive Intracerebral Hemorrhage[J].Journal of Medical Information,2018,31(21):105.[doi:10.3969/j.issn.1006-1959.2018.05.035]
[3]雷 明.微创穿刺引流联合开颅血肿清除术治疗高血压脑出血 并发脑疝临床效果观察[J].医学信息,2018,31(07):89.[doi:10.3969/j.issn.1006-1959.2018.07.028]
　LEI Ming.Clinical Effect of Minimally Invasive Puncture Drainage Combined with Craniotomy Hematoma in the Treatment of Hypertensive Cerebral Hemorrhage Complicated with Cerebral Hernia[J].Journal of Medical Information,2018,31(21):89.[doi:10.3969/j.issn.1006-1959.2018.07.028]
[4]陈春香,顾宇丹.循证护理干预对高血压脑出血与患者心理状态恢复及 并发症的影响[J].医学信息,2018,31(14):180.[doi:10.3969/j.issn.1006-1959.2018.14.057]
　CHEN Chun-xiang,GU Yu-dan.Effect of Evidence-based Nursing Intervention on Hypertensive Cerebral Hemorrhage and Recovery of Patients' Psychological State and Complications[J].Journal of Medical Information,2018,31(21):180.[doi:10.3969/j.issn.1006-1959.2018.14.057]
[5]陈加富,陈新生.右正中神经电刺激对高血压脑出血后昏迷患者早期促醒治疗的研究[J].医学信息,2018,31(22):85.[doi:10.3969/j.issn.1006-1959.2018.22.023]
　CHEN Jia-fu,CHEN Xin-sheng.Study of the Clinical Effect of the Early Right Median Nerve Electrical Stimulation to Hypertensive Intracerebral Hemorrhage-induced Coma[J].Journal of Medical Information,2018,31(21):85.[doi:10.3969/j.issn.1006-1959.2018.22.023]
[6]袁新春,董 伟,潘泰峰.血清D-二聚体水平与高血压脑出血患者病情严重程度及术后预后的关系[J].医学信息,2022,35(13):165.[doi:10.3969/j.issn.1006-1959.2022.13.041]
　YUAN Xin-chun,DONG Wei,PAN Tai-feng.The Relationship Between Serum D-dimer Level and the Severity and Postoperative Prognosis of Patients with Hypertensive Cerebral Hemorrhage[J].Journal of Medical Information,2022,35(21):165.[doi:10.3969/j.issn.1006-1959.2022.13.041]
[7]王春城.神经内镜辅助对高血压脑出血中患者神经缺损及安全性的影响[J].医学信息,2019,32(08):139.[doi:10.3969/j.issn.1006-1959.2019.08.041]
　WANG Chun-cheng.Effect of Neuroendoscopy on Neurological Deficit and Safety in Patients with Hypertensive Brain Hemorrhage[J].Journal of Medical Information,2019,32(21):139.[doi:10.3969/j.issn.1006-1959.2019.08.041]
[8]刘 宏,吴政俊,何明方.开颅减压结合脑室外引流术对高血压脑出血破入脑室 感染及预后的影响[J].医学信息,2019,32(12):112.[doi:10.3969/j.issn.1006-1959.2019.12.035]
　LIU Hong,WU Zheng-jun,HE Ming-fang.Effect of Craniotomy and Decompression Combined with Extraventricular Drainage on Cerebral Ventricular Infection and Prognosis of Hypertensive Intracerebral Hemorrhage[J].Journal of Medical Information,2019,32(21):112.[doi:10.3969/j.issn.1006-1959.2019.12.035]
[9]韩 晋,陈淑媛,董瑞宾,等.神经生长因子与盐酸氟桂利嗪联合治疗高血压脑出血的疗效[J].医学信息,2019,32(21):81.[doi:10.3969/j.issn.1006-1959.2019.21.025]
　HAN Jin,CHEN Shu-yuan,DONG Rui-bin,et al.Effect of Nerve Growth Factor Combined with Flunarizine Hydrochloride on Hypertensive Intracerebral Hemorrhage[J].Journal of Medical Information,2019,32(21):81.[doi:10.3969/j.issn.1006-1959.2019.21.025]
[10]吴六仔.纳络酮联合局部亚低温治疗高血压脑出血的疗效及对患者神经功能恢复、认知改善的影响[J].医学信息,2022,35(16):125.[doi:10.3969/j.issn.1006-1959.2022.16.031]
　WU Liu-zi.Effect of Naloxone Combined with Local Mild Hypothermia on Hypertensive Cerebral Hemorrhage and its Effect on Neurological Function Recovery and Cognitive Improvement[J].Journal of Medical Information,2022,35(21):125.[doi:10.3969/j.issn.1006-1959.2022.16.031]

更新日期/Last Update: 1900-01-01