[1]朱子观,苏朝江,姜 燕.高通量血液透析联合加巴喷丁治疗血液透析患者不安腿综合征的临床效果[J].医学信息,2024,37(07):124-126,130.[doi:10.3969/j.issn.1006-1959.2024.07.024]
　ZHU Zi-guan,SU Chao-jiang,JIANG Yan.Clinical Effect of High Flux Hemodialysis Combined with Gabapentin in the Treatment of Restless Leg Syndrome in Hemodialysis Patients[J].Journal of Medical Information,2024,37(07):124-126,130.[doi:10.3969/j.issn.1006-1959.2024.07.024]
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高通量血液透析联合加巴喷丁治疗血液透析患者不安腿综合征的临床效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年07期
页码:
124-126,130
栏目:
论著
出版日期:
2024-04-01

文章信息/Info

Title:
Clinical Effect of High Flux Hemodialysis Combined with Gabapentin in the Treatment of Restless Leg Syndrome in Hemodialysis Patients
文章编号:
1006-1959（2024）07-0124-04
作者:
朱子观; 苏朝江; 姜 燕
（1.德江县人民医院肾内科，贵州 德江 565200；2.贵州医科大学附属肿瘤医院肾内科，贵州 贵阳 550003）
Author(s):
ZHU Zi-guan; SU Chao-jiang; JIANG Yan
(1.Department of Nephrology,Dejiang County People’s Hospital,Dejiang 565200,Guizhou,China;2.Departmengt of Nephrology,Cancer Hospital Affiliated to Guizhou Medical University,Guiyang 550003,Guizhou,China)
关键词:
高通量血液透析; 加巴喷丁; 血液透析; 不安腿综合征
Keywords:
High flux hemodialysis; Gabapentin; Hemodialysis; Restless legs syndrome
分类号:
R746.9
DOI:
10.3969/j.issn.1006-1959.2024.07.024
文献标志码:
A
摘要:
目的 观察高通量血液透析（HFHD）联合加巴喷丁治疗维持性血液透析患者不安腿综合征（RLS）的临床效果。方法 选取2021年6月-2022年2月德江县人民医院血液净化中心符合RLS诊断标准的规律血液透析治疗患者40例作为研究对象。采用随机分组法将患者分为观察组和对照组，每组20例。对照组予以常规血液透析治疗，观察组予以HFHD联合加巴喷丁治疗，比较两组临床疗效、国际不安腿综合征研究组（IRLSSG）评分、匹茨堡睡眠质量指数量表（PSQI）评分及血β2-微球蛋白（β2-MG）、全段甲状旁腺素（iPTH）、单室尿素清除指数（Kt/V）水平、不良反应发生情况。结果 观察组治疗总有效率高于对照组（P＜0.05）；观察组治疗后IRLSSG评分、PSQI评分、β2-MG、iPTH水平低于对照组，Kt/V水平高于对照组（P＜0.05）；两组均未发生严重不良反应。结论 血液透析患者采用HFHD联合加巴喷丁治疗可降低β2-MG、iPTH水平，改善RLS症状及患者睡眠质量，值得临床应用。
Abstract:
Objective To observe the clinical effect of high flux hemodialysis (HFHD) combined with gabapentin in the treatment of restless legs syndrome (RLS) in maintenance hemodialysis patients.Methods From June 2021 to February 2022, 40 patients with regular hemodialysis who met the diagnostic criteria of RLS in the blood purification center of Dejiang County People’s Hospital were selected as the research objects. The patients were divided into observation group and control group by random grouping method, with 20 patients in each group. The control group was treated with routine hemodialysis, and the observation group was treated with HFHD combined with gabapentin. The clinical efficacy, International Restless Legs Syndrome Study Group (IRLSSG) score, Pittsburgh Sleep Quality Index (PSQI) score, blood β2-microglobulin (β2-MG), intact parathyroid hormone (iPTH), single partment urea clearance index (Kt/V) level and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group (P<0.05). After treatment, the IRLSSG score, PSQI score, β2-MG and iPTH levels in the observation group were lower than those in the control group, and the Kt/V level was higher than that in the control group (P<0.05). Both groups had no serious adverse reactions.Conclusion HFHD combined with gabapentin in hemodialysis patients can reduce the levels of β2-MG and iPTH, improve RLS symptoms and sleep quality of patients, which is worthy of clinical application.

参考文献/References:

[1]Turk AC,Ozkurt S,Turgal E,et al.The association between the prevalence of restless leg syndrome,fatigue,and sleep quality in patients undergoing hemodialysis[J].Saudi Med J,2018,39(8):792-798.[2]Gossard TR,Trotti LM,Videnovic A,et al.Restless legs syndrome: contemporary diagnosis and treatment[J].Neurotherapeutics,2021,18(1):140-155.[3]Beladi-Mousavi SS,Jafarizade M,Shayanpour S,et al.Restless Legs Syndrome: associated risk factors in hemodialysis patients[J].Nephrourol Mon,2015,7(6):e31967.]Lin CH,Wu VC,Li WY,et al.Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan[J].Eur J Neurol,2013,20(7):1025-1031.[5]Xia M,He Q,Ying G,et al.Clinical Efficacy and Safety of Massage for the Treatment of Restless Leg Syndrome in Hemodialysis Patients: A Meta-Analysis of 5 Randomized Controlled Trials[J].Front Psychiatry,2022,13:843263.[6]李红敏,郭军会,陈元武,等.围刺法联合加味芍药甘草汤治疗不宁腿综合征疗效及对患者睡眠周期性肢体运动指数和25-羟基维生素D的影响[J].陕西中医,2023,44(1):119-123.[7]韩磊.蔗糖铁配合活血安神方治疗尿毒症维持性血液透析并发不安腿综合征的疗效及对功能性缺铁状态及睡眠质量的影响[J].现代中西医结合杂志,2020,29(18):1990-1994.[8]高丽华,孙妍,邓春颖,等.高通量血液透析对维持性血液透析患者不安腿及睡眠质量的改善作用[J].华南国防医学杂志,2021,35(2):108-111.[9]郑凤云,周健美.维生素B12联合加巴喷丁治疗维持性血液透析患者不安腿综合征的效果[J].国际移植与血液净化杂志,2020,18(6):20-22.[10]龚豪,黄丽,张庆红,等.高通量血液透析和血液透析滤过 对慢性肾功能衰竭患者临床疗效、肾功能及毒素清除率 的影响[J].解放军医药杂志,2019,31(8):62-65.[11]王宇静，钟育祥.不同血液净化对 DN 慢性肾衰竭患者 血清脂肪及炎性因子水平的影响[J].贵州医科大学学报,2019,44(8):960-964．[12]余彬,暴小方,张新庄,等.高通量血液透析与低通量血液透析在尿毒症患者中的应用效果[J].河南医学研究,2022,31(9):1658-1661.[13]彭李,杨建兵.高通量血液透析对糖尿病肾病患者心功能及血清BNP、cTnI、CK-MB水平的影响[J].中国中西医结合肾病杂志,2020,21(4):346-348.[14]Abdelsalam M,Demerdash TM,Assem M,et al.Improvement of clinical outcomes in dialysis: No convincing superiority in dialysis efficacy using hemodiafiltration vs high‐flux hemodialysis[J].Therapeutic Apheresis and Dialysis,2021,25(4):483-489.[15]薛贤.高通量血液透析联合腹膜透析治疗尿毒症的临床分析[J].临床医学,2022,42(9):61-62.[16]徐涛,郝丽梅,刘长春,等.多巴胺受体激动剂普拉克索治疗原发性不宁腿综合征[J].临床军医杂志,2016,44(3):275-278.[17]Gonzalez-Latapi P,Malkani R.Update on restless legs syndrome: from mechanisms to treatment[J].Current Neurology and Neuroscience Reports,2019,19:1-12.[18]邱琳蕊,张睿健,廖丽萍.组合型人工肾联合加巴喷丁治疗维持性血液透析并发不宁腿综合征的有效性和安全性[J].临床合理用药,2023,16(6):111-113.[19]Winkelmann J,Allen R P,H?觟gl B,et al.Treatment of restless legs syndrome:Evidence‐based review and implications for clinical practice (Revised 2017)[J].Movement Disorders,2018,33(7):1077-1091.[20]史春红,孙瑶,李秀娟.血液灌流联合加巴喷丁治疗维持性血液透析患者不宁腿综合征的临床疗效观察[J].中国中西医结合急救杂志,2016,23(6):655-656.

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更新日期/Last Update: 1900-01-01