[1]彭全林,钟丽丽,罗礼亮,等.熟地黄联合椎体成形术治疗帕金森病合并胸腰椎骨质疏松性压缩性骨折的临床疗效[J].医学信息,2024,37(17):131-134.[doi:10.3969/j.issn.1006-1959.2024.17.028]
　PENG Quan-lin,ZHONG Li-li,LUO Li-liang,et al.Clinical Efficacy of Shudihuang Combined with Vertebroplasty in the Treatment of Parkinson’s Disease Complicated with Thoracolumbar Osteoporotic Compression Fractures[J].Journal of Medical Information,2024,37(17):131-134.[doi:10.3969/j.issn.1006-1959.2024.17.028]
点击复制

熟地黄联合椎体成形术治疗帕金森病合并胸腰椎骨质疏松性压缩性骨折的临床疗效()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年17期
页码:
131-134
栏目:
中医中药
出版日期:
2024-09-01

文章信息/Info

Title:
Clinical Efficacy of Shudihuang Combined with Vertebroplasty in the Treatment of Parkinson’s Disease Complicated with Thoracolumbar Osteoporotic Compression Fractures
文章编号:
1006-1959（2024）17-0131-04
作者:
彭全林; 钟丽丽; 罗礼亮; 兰义鑫; 蔡伟华
上犹县中医院骨二科，江西 上犹 341200
Author(s):
PENG Quan-lin; ZHONG Li-li; LUO Li-liang; LAN Yi-xin; CAI Wei-hua
The Second Department of Orthopaedics,Shangyou County Hospital of Traditional Chinese Medicine,Shangyou 341200,Jiangxi,China
关键词:
熟地黄; 椎体成形术; 帕金森病; 胸腰椎; 骨质疏松性压缩性骨折
Keywords:
Shudihuang; Vertebroplasty; Parkinson’s disease; Thoracolumbar spine; Osteoporotic compression fracture
分类号:
R742.5；R683
DOI:
10.3969/j.issn.1006-1959.2024.17.028
文献标志码:
A
摘要:
目的 观察熟地黄联合椎体成形术治疗帕金森病合并胸腰椎骨质疏松性压缩性骨折的临床效果。方法 选取2020年1月1日-2023年8月1日我院诊治的58例帕金森病合并胸腰椎骨质疏松性压缩性骨折为研究对象，采用随机数字表法分为对照组（n=29）和观察组（n=29）。对照组单纯采用椎体成形术治疗，观察组在对照组基础上联合应用熟地黄，比较两组临床胸腰椎功能恢复优良率、帕金森病评定量表（UPDRS）评分、Oswestr功能障碍指数（ODI）评分、椎体前缘高度、疼痛评分（VAS）、帕金森病生活质量评分（PDQ-39）。结果 观察组胸腰椎功能恢复优良率为93.10%，高于对照组的82.76%（P＜0.05）；两组治疗后UPDRS评分均低于治疗前，且观察组低于对照组（P＜0.05）；两组治疗后ODI评分均低于治疗前，且观察组低于对照组（P＜0.05）；两组治疗后椎体前缘高度均大于治疗前，且观察组大于对照组（P＜0.05）；两组治疗后VAS评分均低于治疗前，且观察组低于对照组（P＜0.05）；两组治疗后PDQ-39评分均低于治疗前，且观察组低于对照组（P＜0.05）。结论 熟地黄联合椎体成形术治疗帕金森病合并胸腰椎骨质疏松性压缩性骨折的效果确切，可促进胸腰椎功能恢复，减轻帕金森病症状，改善患者功能障碍，增大椎体前缘高度，降低患者疼痛程度，进而提高患者生活质量。
Abstract:
Objective To observe the clinical effect of Shudihuang combined with vertebroplasty in the treatment of Parkinson’s disease with thoracolumbar osteoporotic compression fractures.Methods From January 1, 2020 to Augest 1， 2023, 58 patients of Parkinson’s disease complicated with thoracolumbar osteoporotic compression fractures in our hospital were selected as the research objects. They were divided into control group (n=29) and observation group (n=29) by random number table method. The control group was treated with vertebroplasty alone, and the observation group was combined with Shudihuang on the basis of the control group. The excellent and good rate of clinical thoracolumbar function recovery, Unified Parkinson’s disease rating scale (UPDRS) score, Oswestry Disability Index (ODI) score, anterior vertebral height, pain score (VAS), and Parkinson’s Disease Questionnaire (PDQ-39) were compared between the two groups.Results The excellent and good rate of thoracolumbar function recovery in the observation group was 93.10%, which was higher than 82.76% in the control group (P<0.05). The UPDRS score of the two groups after treatment was lower than that before treatment, and that of the observation group was lower than that of the control group (P<0.05). The ODI score of the two groups after treatment was lower than that before treatment, and that of the observation group was lower than that of the control group (P<0.05). After treatment, the anterior vertebral height of the two groups was higher than that before treatment, and that of the observation group was higher than that of the control group (P<0.05). After treatment, the VAS score of the two groups was lower than that before treatment, and that of the observation group was lower than that of the control group (P<0.05). After treatment, the PDQ-39 score of the two groups was lower than that before treatment, and that of the observation group was lower than that of the control group (P<0.05).Conclusion Shudihuang combined with vertebroplasty is effective in the treatment of Parkinson’s disease with thoracolumbar osteoporotic compression fractures, which can promote the recovery of thoracolumbar function, reduce the symptoms of Parkinson’s disease, improve the dysfunction of patients, increase the height of the anterior edge of the vertebral body, reduce the degree of pain of patients, and improve the quality of life of patients.

参考文献/References:

[1]杜江,孟利锋,贺竟哲.补肾健骨汤联合西药治疗老年骨质疏松性胸腰椎压缩性骨折临床观察[J].社区医学杂志,2019,17(15):931-933.[2]李关鑫,郑金尧,冯伟利.益肾补骨汤联合椎体成形术治疗老年骨质疏松性胸腰椎压缩骨折76例[J].中医研究,2019,32(3):41-43.[3]吴俊彪,方弘伟,黄晓东,等.钱氏通痹和身方联合经皮椎体成形术治疗老年骨质疏松性胸腰椎压缩性骨折肾虚血瘀证50例[J].浙江中医杂志,2020,55(1):62-63.[4]梁启楼,徐禄基,周启付.补肾益精汤联合PKP治疗老年骨质疏松性胸腰椎压缩性骨折患者的疗效分析[J].云南中医学院学报,2018,41(3):69-72.[5]王楠,许建柱,陈恩良,等.经皮椎弓根螺钉结合椎体成形术治疗骨质疏松性胸腰段骨折[J].中国骨伤,2018,31(4):339-346.[6]林朝迪,杨梓华,陈明辉.补肾壮骨汤辅助治疗老年骨质疏松性胸腰椎压缩性骨折的效果及对患者血清Leptin水平、生活质量的影响[J].中医临床研究,2019,11(18):128-129,144.[7]程永远.益肾补骨汤联合椎体成形术治疗老年骨质疏松性胸腰椎压缩骨折临床观察[J].陕西中医,2017,38(1):76-78.[8]刘小可,叶品良,陈翼,等.《辨证录》熟地用药特点分析[J].中国中医基础医学杂志,2020,26(11):1699-1701.[9]滕龙,洪芳,何建成.中药复方地黄方对帕金森病异动症模型大鼠△FosB mRNA及蛋白表达的影响[J].中华中医药杂志,2018,33(10):4403-4406.[10]孙雪,梁建庆,何建成,等.神经营养因子与帕金森病DA能神经元再生[J].中国老年学杂志,2020,40(13):2904-2908.[11]Liang Y,Chen C,Xia B,et al.Neuroprotective Effect of Echinacoside in Subacute Mouse Model of Parkinson’s Disease[J].Biomed Res Int,2019,2019:4379639.[12]冯玉龙,夏俊博.地黄益智方联合脑蛋白水解物治疗帕金森病痴呆的临床研究[J].中西医结合心脑血管病杂志,2019,17(13):2030-2034.[13]陈昕彦,李湘,于萌,等.唑来膦酸在胸腰椎骨质疏松性压缩性骨折患者PKP术后的应用观察[J].颈腰痛杂志,2018,39(2):154-157.[14]顾超,沈婷,袁灿兴,等.地黄益智方联合盐酸多奈哌齐治疗帕金森病痴呆临床研究[J].四川中医,2016,34(9):107-111.[15]杨旭,王花欣,张倩,等.六味地黄丸联合密固达对骨质疏松症的临床疗效及生活质量的影响[J].中国实验方剂学杂志,2022,28(14):115-120.[16]李伦莘,吴连国,梁博程,等.六味地黄丸防治肾阴虚型绝经后骨质疏松的临床疗效评价[J].中华全科医学,2022,20(8):1392-1395.[17]安娟,匡浩铭,李振宇,等.六味地黄丸治疗2型糖尿病性骨质疏松症的疗效评价[J].湖南中医药大学学报,2022,42(7):1216-1220.[18]于雪冰,马建强,汪栋,等.六味地黄丸治疗绝经后骨质疏松症肾阴虚证对骨钙素、骨密度及JAK/STAT信号通路的影响[J].中药材,2020,43(3):734-737.[19]郭志颖.益肾补骨汤联合椎体成形术治疗老年骨质疏松性胸腰椎压缩性骨折的临床疗效观察[J].实用中西医结合临床,2019,19(6):33-35.[20]张焕香.地黄益智汤联合西医治疗血管性帕金森综合征的疗效观察[J].河北中医,2022,44(2):244-247.

相似文献/References:

[1]杨可佳,孙春华,洪全明,等.经皮椎体成形术治疗骨质疏松性压缩性椎体骨折的疗效观察[J].医学信息,2018,31(17):98.[doi:10.3969/j.issn.1006-1959.2018.17.030]
　YANG Ke-jia,SUN Chun-hua,HONG Quan-ming,et al.Therapeutic Effect of Percutaneous Vertebroplasty for treatment of Osteoporotic Vertebral Compression Fracture[J].Journal of Medical Information,2018,31(17):98.[doi:10.3969/j.issn.1006-1959.2018.17.030]
[2]杨 杰,彭旭东,叶小斌.椎体成形术单双侧注入骨水泥治疗OVCF的效果分析[J].医学信息,2018,31(24):95.[doi:10.3969/j.issn.1006-1959.2018.24.026]
　YANG Jie.Analysis of the Effect of Vertebroplasty with Single and Bilateral Injection of Bone Cement in the treatment of OVCF[J].Journal of Medical Information,2018,31(17):95.[doi:10.3969/j.issn.1006-1959.2018.24.026]
[3]谭兆惠.经皮椎体成形术与经皮椎体后凸成形术治疗重度骨质疏松性椎体压缩骨折的疗效[J].医学信息,2019,32(24):111.[doi:10.3969/j.issn.1006-1959.2019.24.038]
　TAN Zhao-hui.Efficacy of Percutaneous Vertebroplasty and Percutaneous Kyphoplasty for Severe Osteoporotic Vertebral Compression Fractures[J].Journal of Medical Information,2019,32(17):111.[doi:10.3969/j.issn.1006-1959.2019.24.038]
[4]李卫科,诸赛玲.经皮椎体后凸成形术对老年胸腰椎骨折患者椎体功能恢复及并发症的影响[J].医学信息,2021,34(22):60.[doi:10.3969/j.issn.1006-1959.2021.22.017]
　LI Wei-ke,ZHU Sai-ling.Effect of Percutaneous Kyphoplasty on Vertebral Function Recovery and Complications in Elderly Patients with Thoracolumbar Fractures[J].Journal of Medical Information,2021,34(17):60.[doi:10.3969/j.issn.1006-1959.2021.22.017]
[5]王彦金,周英杰,黄 勇.单、双侧椎弓根入路经皮椎体成形术治疗骨质疏松型椎体压缩骨折的对比研究[J].医学信息,2023,36(08):127.[doi:10.3969/j.issn.1006-1959.2023.08.027]
　WANG Yan-jin,ZHOU Ying-jie,HUANG Yong,et al.Comparative Study of Unilateral and Bilateral Pedicle Approach Percutaneous Vertebroplasty in the Treatment of Osteoporotic Vertebral Compression Fractures[J].Journal of Medical Information,2023,36(17):127.[doi:10.3969/j.issn.1006-1959.2023.08.027]
[6]袁圣薰,杨蓉华.MRI影像特征评估在椎体成形术前胸腰椎骨折患者中的应用价值[J].医学信息,2024,37(17):150.[doi:10.3969/j.issn.1006-1959.2024.17.033]
　YUAN Sheng-xun,YANG Rong-hua.Application Value of MRI Image Feature Evaluation in Patients with Thoracic and Lumbar Fractures Before Vertebroplasty[J].Journal of Medical Information,2024,37(17):150.[doi:10.3969/j.issn.1006-1959.2024.17.033]

更新日期/Last Update: 1900-01-01