[1]刘雨虹.血清AFP、CEA和CA199联合检测在丙肝相关肝硬化和肝癌鉴别诊断中的临床价值[J].医学信息,2024,37(17):139-141145.[doi:10.3969/j.issn.1006-1959.2024.17.030]
 LIU Yu-hong.Clinical Value of Combined Detection of Serum AFP, CEA and CA199 in the Differential Diagnosisof Hepatitis C-related Cirrhosis and Liver Cancer[J].Journal of Medical Information,2024,37(17):139-141145.[doi:10.3969/j.issn.1006-1959.2024.17.030]
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血清AFP、CEA和CA199联合检测在丙肝相关肝硬化和肝癌鉴别诊断中的临床价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年17期
页码:
139-141145
栏目:
诊疗技术
出版日期:
2024-09-01

文章信息/Info

Title:
Clinical Value of Combined Detection of Serum AFP, CEA and CA199 in the Differential Diagnosisof Hepatitis C-related Cirrhosis and Liver Cancer
文章编号:
1006-1959(2024)17-0139-04
作者:
刘雨虹
石城县人民医院检验科,江西 石城 342700
Author(s):
LIU Yu-hong
Laboratory Department of Shicheng County People’s Hospital,Shicheng 342700,Jiangxi,China
关键词:
丙肝相关肝硬化肝癌血清甲胎蛋白癌胚抗原糖类抗原199
Keywords:
Hepatitis C-related cirrhosisLiver cancerSerum alpha-fetoproteinCarcinoembryonic antigenCarbohydrate antigen 199
分类号:
R735.7;R575.2
DOI:
10.3969/j.issn.1006-1959.2024.17.030
文献标志码:
A
摘要:
目的 研究血清甲胎蛋白(AFP)、癌胚抗原(CEA)和糖类抗原199(CA199)联合检测在丙肝相关肝硬化(HCV-Cirr)和肝癌(LC)鉴别诊断中的临床价值。方法 选取2021年10月-2023年4月石城县人民医院收治的48例HCV-Cirr患者设为HCV-Cirr组,另取同期确诊的14例LC患者设为LC组,比较两组血清AFP、CEA、CA199水平,统计血清AFP、CEA、CA199指标单独及联合检测在HCV-Cirr与LC中的阳性检出率,随后分析并比较血清AFP、CEA、CA199指标单独及联合检测对HCV-Cirr与LC的鉴别诊断价值。结果 LC组血清AFP、CEA、CA199水平高于HCV-Cirr组(P<0.05);血清AFP、CEA、CA199联合检测的HCV-Cirr阳性检出率、LC阳性检出率高于其单独检测(P<0.05);血清AFP、CEA、CA199联合检测对HCV-Cirr与LC的鉴别诊断准确性、敏感度与特异度高于其单独检测(P<0.05)。结论 血清AFP、CEA、CA199指标在HCV-Cirr与LC检测中具有确切诊断作用,三者联合检测具有更高鉴别诊断价值。
Abstract:
Objective To study the clinical value of combined detection of serum alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) in the differential diagnosis of hepatitis C-related cirrhosis (HCV-Cirr) and liver cancer (LC).Methods A total of 48 patients with HCV-Cirr admitted to Shicheng County People’s Hospital from October 2021 to April 2023 were selected as the HCV-Cirr group, and 14 patients with LC diagnosed at the same time were selected as the LC group. The levels of serum AFP, CEA and CA199 were compared between the two groups. The positive detection rates of serum AFP, CEA and CA199 alone and combined detection in HCV-Cirr and LC were counted. Then the differential diagnostic value of serum AFP, CEA and CA199 alone and combined detection in HCV-Cirr and LC was analyzed and compared.Results The levels of serum AFP, CEA and CA199 in LC group were higher than those in HCV-Cirr group (P<0.05). The HCV-Cirr positive detection rate and LC positive detection rate of combined detection of serum AFP, CEA and CA199 were higher than those of single detection (P<0.05). The accuracy, sensitivity and specificity of combined detection of serum AFP, CEA and CA199 in the differential diagnosis of HCV-Cirr and LC were higher than those of single detection (P<0.05).Conclusion Serum AFP, CEA and CA199 indicators have a definite diagnostic effect in the detection of HCV-Cirr and LC, and the combined detection of the three has a higher differential diagnostic value.

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更新日期/Last Update: 1900-01-01