[1]税 莲,邓海军,刘广国,等.卡培他滨联合安罗替尼三线治疗晚期非小细胞肺癌的安全性和有效性[J].医学信息,2024,37(21):30-34.[doi:10.3969/j.issn.1006-1959.2024.21.006]
 SHUI Lian,DENG Haijun,LIU Guangguo,et al.Safety and Efficacy of Capecitabine Combined with Anlotinib in the Third-line Treatment of Advanced Non-small Cell Lung Cancer[J].Journal of Medical Information,2024,37(21):30-34.[doi:10.3969/j.issn.1006-1959.2024.21.006]
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卡培他滨联合安罗替尼三线治疗晚期非小细胞肺癌的安全性和有效性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年21期
页码:
30-34
栏目:
论著
出版日期:
2024-11-01

文章信息/Info

Title:
Safety and Efficacy of Capecitabine Combined with Anlotinib in the Third-line Treatment of Advanced Non-small Cell Lung Cancer
文章编号:
1006-1959(2024)21-0030-05
作者:
税 莲邓海军刘广国苏 州罗文娟
绵阳四〇四医院肿瘤科,四川 绵阳 621000
Author(s):
SHUI LianDENG HaijunLIU GuangguoSU ZhouLUO Wenjuan
Oncology Department of Mianyang 404 Hospital,Mianyang 621000,Sichuan,China
关键词:
三线非小细胞肺癌安罗替尼卡培他滨
Keywords:
Third-line treatment of advanced non-small cell lung cancerAnlotinibCapecitabine
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2024.21.006
文献标志码:
A
摘要:
目的 探讨卡培他滨联合安罗替尼在晚期非小细胞肺癌三线治疗的安全性和有效性。方法 选择本院2018年12月-2021年12月二线治疗失败的晚期非小细胞肺癌患者60例,随机分为观察组和对照组,各30例。观察组口服卡培他滨联合安罗替尼同步治疗,对照组口服安罗替尼单药治疗。比较两组不良反应发生率、客观缓解率(ORR)、疾病控制率(DCR),随访1年观察无疾病生存时间(PFS)。结果 观察组客观缓解率为33.33%、疾病控制率为80.00%,优于对照组的10.00%、30.00%,差异有统计学意义(P<0.05)。观察组的PFS约为7.73个月,优于对照组的5.78个月,差异有统计学意义(P<0.05)。观察组的口腔黏膜反应、手足综合征发生率分别高于对照组,差异有统计学意义(P<0.05);两组高血压、蛋白尿、肝功能损失发生率比较,差异无统计学意义(P>0.05)。结论 卡培他滨联合安罗替尼能安全有效的治疗NSCLC,并且延长患者生存时间。
Abstract:
Objective To investigate the safety and efficacy of capecitabine combined with anlotinib in the third-line treatment of advanced non-small cell lung cancer.Methods A total of 60 patients with advanced non-small cell lung cancer who failed second-line treatment in our hospital from December 2018 to December 2021 were randomly divided into observation group and control group, with 30 patients in each group. The observation group was treated with capecitabine combined with anlotinib, while the control group was treated with anlotinib monotherapy. The incidence of adverse reactions, objective remission rate (ORR) and disease control rate (DCR) were compared between the two groups, and the disease-free survival time (PFS) was observed after 1 year of follow-up.Results The objective remission rate of the observation group was 33.33%, and the disease control rate was 80.00%, which were better than 10.00%, 30.00% of the control group, the difference were statistically significant (P<0.05). The PFS of the observation group was about 7.73 months, which was better than 5.78 months of the control group, and the difference was statistically significant (P<0.05). The incidence of oral mucosal reaction and hand-foot syndrome in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of hypertension, proteinuria and liver function loss between the two groups (P>0.05).Conclusion Capecitabine combined with anlotinib is safe and effective in the treatment of NSCLC and prolongs the survival time of patients.

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更新日期/Last Update: 1900-01-01