[1]殷章圣,侯克莉,邹云龙.血必净注射液协同亚胺培南对脓毒血症患者预后的影响[J].医学信息,2024,37(21):115-118，129.[doi:10.3969/j.issn.1006-1959.2024.21.026]
　YIN Zhangsheng,HOU Keli,ZOU Yunlong.Effect of Xuebijing Injection Combined with Imipenem on Prognosis of Patients with Sepsis[J].Journal of Medical Information,2024,37(21):115-118，129.[doi:10.3969/j.issn.1006-1959.2024.21.026]
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血必净注射液协同亚胺培南对脓毒血症患者预后的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年21期
页码:
115-118，129
栏目:
药物与临床
出版日期:
2024-11-01

文章信息/Info

Title:
Effect of Xuebijing Injection Combined with Imipenem on Prognosis of Patients with Sepsis
文章编号:
1006-1959（2024）21-0115-05
作者:
殷章圣; 侯克莉; 邹云龙
赣州市赣县区人民医院综合ICU，江西 赣州 341100
Author(s):
YIN Zhangsheng; HOU Keli; ZOU Yunlong
ICU of Ganzhou Ganxian District People’s Hospital,Ganzhou 341100,Jiangxi,China
关键词:
脓毒血症; 血必净注射液; 亚胺培南; 炎症反应; 凝血功能; 免疫功能
Keywords:
Sepsis; Xuebijing injection; Imipenem; Inflammatory response; Coagulation function; Immunologic function
分类号:
R515.3
DOI:
10.3969/j.issn.1006-1959.2024.21.026
文献标志码:
A
摘要:
目的 研究血必净注射液协同亚胺培南对脓毒血症患者预后的影响。方法 选取2020年1月-2023年9月赣州市赣县区人民医院综合ICU收治的240例脓毒血症患者，经随机数字表法分为A组（80例）、B组（80例）、C组（80例），A组给予亚胺培南治疗，B组给予血必净注射治疗，C组采用血必净注射液协同亚胺培南治疗，比较三组病死率（治疗后28d）、病情严重程度[急性生理与慢性健康评分（APACHEⅡ）]、ICU住院时间、凝血功能指标[纤维蛋白原（FIB）、血小板计数（PLT）、D-二聚体（D-D）、凝血酶时间（TT）]、炎症指标[降钙素原（PCT）、高敏C反应蛋白（hs-CRP）、淀粉样蛋白A（SAA）]、免疫功能指标[CD3+、CD4+、CD8+、CD4+/CD8+、免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、免疫球蛋白M（IgM）]。结果 C组病死率、ICU住院时间少于A组、B组（P＜0.05），且C组治疗后APACHEⅡ评分低于A组、B组（P＜0.05）。C组治疗后FIB、PLT、D-D水平低于A组、B组，TT水平高于A组、B组（P＜0.05）。C组治疗后PCT、hs-CRP、SAA水平低于A组、B组（P＜0.05）。C组治疗后CD3+、CD4+、CD4+/CD8+、IgA、IgG、IgM水平高于A组、B组，CD8+低于A组、B组（P＜0.05）。结论 血必净注射液协同亚胺培南可降低脓毒血症病死风险，减轻疾病严重程度，缩短患者的ICU住院时间，下调其炎症因子水平，改善机体凝血状态与免疫功能。
Abstract:
Objective To study the effect of Xuebijing injection combined with imipenem on the prognosis of patients with sepsis.Methods A total of 240 patients with sepsis admitted to the general ICU of Ganzhou Ganxian District People’s Hospital from January 2020 to September 2023 were selected and divided into group A (80 patients), group B (80 patients) and group C (80 patients) by random number table method. Group A was treated with imipenem, group B was treated with Xuebijing injection, and group C was treated with Xuebijing injection combined with imipenem. The mortality rate (28 days after treatment), severity of disease [Acute Physiology and Chronic Health Evaluation score (APACHEⅡ)], ICU hospitalization time, coagulation function indexes [fibrinogen (FIB), platelet count (PLT), D-dimer (D-D), thrombin time (TT)], inflammation indexes [procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), amyloid A (SAA)], immune function indexes [CD3+, CD4+, CD8+, CD4+/CD8+, immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM)] were compared among the three groups.Results The mortality and ICU hospitalization time of group C were less than those of group A and group B (P<0.05), and the APACHEⅡ score of group C was lower than that of group A and group B (P<0.05). After treatment, the levels of FIB, PLT and D-D in group C were lower than those in group A and group B, and the level of TT was higher than that in group A and group B (P<0.05). After treatment, the levels of PCT, hs-CRP and SAA in group C were lower than those in group A and group B (P<0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+, IgA, IgG and IgM in group C were higher than those in group A and group B, and CD8+ was lower than those in group A and group B (P<0.05).Conclusion Xuebijing injection combined with imipenem can reduce the risk of sepsis death, reduce the severity of the disease, shorten the ICU hospitalization time of patients, down-regulate the level of inflammatory factors, and improve the coagulation status and immune function of the body.

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更新日期/Last Update: 1900-01-01