[1]黄榕梅,钟晓青,肖巧玲.不同激素替代治疗方案对围绝经期综合征患者的影响[J].医学信息,2024,37(23):33-37.[doi:10.3969/j.issn.1006-1959.2024.23.007]
　HUANG Rongmei,ZHONG Xiaoqing,XIAO Qiaoling.Effect of Different Hormone Replacement Therapy on Patients with Perimenopausal Syndrome[J].Journal of Medical Information,2024,37(23):33-37.[doi:10.3969/j.issn.1006-1959.2024.23.007]
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不同激素替代治疗方案对围绝经期综合征患者的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年23期
页码:
33-37
栏目:
论著
出版日期:
2024-12-01

文章信息/Info

Title:
Effect of Different Hormone Replacement Therapy on Patients with Perimenopausal Syndrome
文章编号:
1006-1959（2024）23-0033-05
作者:
黄榕梅; 钟晓青; 肖巧玲
信丰县妇幼保健院妇产科，江西 信丰 341600
Author(s):
HUANG Rongmei; ZHONG Xiaoqing; XIAO Qiaoling
Department of Obstetrics and Gynecology,Xinfeng County Maternal and Child Health Hospital,Xinfeng 341600,Jiangxi,China
关键词:
激素替代疗法; 围绝经期综合征; 促黄体素
Keywords:
Hormone replacement therapy; Perimenopausal syndrome; Luteinizing hormone
分类号:
R588.6
DOI:
10.3969/j.issn.1006-1959.2024.23.007
文献标志码:
A
摘要:
目的 探究不同激素替代治疗方案对于围绝经期综合征患者症状缓解的影响，为临床制定更合理的治疗方案提供参考。方法 选取信丰县妇幼保健院2022年5月-2023年10月收治的66例围绝经综合征患者作为研究对象，采用随机数字表法分为常规组（33例）和研究组（33例），常规组采用月经后半周期孕激素治疗，研究组采用雌孕激素周期序贯治疗。比较两组子宫状况（子宫内膜厚度、子宫体积）、血脂水平[总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）]、激素水平[促黄体素（LH）、血清雌二醇（E2）和卵泡刺激素（FSH）]、神经递质水平[5-羟色胺（5-HT）、β-内啡肽（β-EP）、去甲肾上腺素（NE）]、Kupperman评分及不良反应（阴道少量出血、乳房胀痛、恶心、腹泻）发生率。结果 两组子宫体积比较，差异无统计学意义（P＞0.05）；研究组子宫内膜厚度低于常规组（P＜0.05）；研究组TC、TG和LDL-C水平低于常规组，HDL-C水平高于常规组（P＜0.05）；研究组LH和FSH水平低于常规组，E2水平高于常规组（P＜0.05）；研究组5-HT和β-EP水平高于常规组，NE水平低于常规组（P＜0.05）；研究组Kupperman评分低于常规组（P＜0.05）；研究组不良反应发生率与常规组比较，差异无统计学意义（P＞0.05）。结论 雌孕激素周期序贯治疗围绝经期综合征患者的疗效确切，能够降低患者Kupperman评分，改善患者子宫内膜厚度和激素水平。
Abstract:
Objective To explore the effect of different hormone replacement therapy on symptom relief in patients with perimenopausal syndrome, and to provide reference for clinical formulation of more reasonable treatment plan.Methods A total of 66 patients with perimenopausal syndrome admitted to Xinfeng County Maternal and Child Health Hospital from May 2022 to October 2023 were selected as the research objects. According to the random number table method, they were divided into routine group and study group, with 33 patients in each group. The routine group was treated with progesterone in the second half of menstruation, and the study group was treated with estrogen and progesterone cycle sequential therapy. The uterine status (endometrial thickness, uterine volume), blood lipid levels [total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)], hormone levels [luteinizing hormone (LH), serum estradiol (E2) and follicle stimulating hormone (FSH)], neurotransmitter levels [5-hydroxytryptamine (5-HT), β-endorphin (β-EP), norepinephrine (NE)], Kupperman score and incidence of adverse reactions (small amount of vaginal bleeding, breast distending pain, nausea and diarrhea) were compared between the two groups.Results There was no significant difference in uterine volume between the two groups (P>0.05). The endometrial thickness of the study group was lower than that of the routine group (P<0.05). The levels of TC, TG and LDL-C in the study group were lower than those in the routine group, and the level of HDL-C was higher than that in the routine group (P<0.05). The levels of LH and FSH in the study group were lower than those in the routine group, and the level of E2 was higher than that in the routine group (P<0.05). The levels of 5-HT and β-EP in the study group were higher than those in the routine group, and the level of NE was lower than that in the routine group (P<0.05). The Kupperman score of the study group was lower than that of the routine group (P<0.05). There was no significant difference in the incidence of adverse reactions between the study group and the routine group (P>0.05).Conclusion Estrogen and progesterone cycle sequential therapy is effective in the treatment of patients with perimenopausal syndrome, which can reduce the Kupperman score, improve the endometrial thickness and hormone level of patients.

参考文献/References:

[1]陈礼梅,林晓洁,徐嘉辉,等.激素替代疗法对改善宫颈鳞状细胞癌术后患者围绝经期综合征的临床观察研究[J].肿瘤预防与治疗,2021,34(6):502-508.[2]丁桂英,余晓.小剂量雌孕激素替代疗法治疗围绝经期综合征的疗效及激素变化探析[J].中国性科学,2019,28(4):104-107.[3]张晨虹,林惠英,魏若菡.不同激素替代治疗对围绝经期综合征妇女的效果比较[J].中国妇幼健康研究,2019,30(6):732-735.[4]成晓玲,周仲瑜,黄伟,等.电针与激素替代疗法比较治疗围绝经期综合征系统评价[J].中国中医药信息杂志,2018,25(3):107-111.[5]李祥芬,高文芳,李相宜,等.低剂量激素替代治疗糖尿病围绝经期综合征的疗效观察[J].西南国防医药,2018,28(2):135-137.[6]魏若菡,阮婴丹,张晨虹,等.针灸联合激素替代疗法治疗围绝经期综合征临床研究[J].新中医,2021,53(6):97-100.[7]焦宏伟.激素替代疗法对围绝经期综合征合并肥胖症患者血脂水平的影响[J].临床药物治疗杂志,2019,17(3):74-78.[8]刘群香,李瑞青,叶海丽.小剂量雌孕激素替代治疗对围绝经期综合征患者性激素水平的影响[J].中国妇幼保健,2020,35(11):2047-2050.[9]李益书,马春季.新加龙牡汤联合激素替代疗法治疗围绝经期综合征临床研究[J].四川中医,2020,38(12):179-182.[10]欧凤柳,胡艳丽.小剂量雌、孕激素替代疗法对围绝经期综合征患者激素水平、Kupperman评分及子宫内膜厚度的影响[J].中国妇幼保健,2018,33(20):4682-4685.[11]古卫华.激素替代治疗围绝经期综合征的应用及意义[J].医药论坛杂志,2018,39(8):154-156.[12]丁坤琼,毛世华,谈宗国.坤泰胶囊与雌激素替代疗法联合治疗围绝经期综合征的疗效分析[J].蚌埠医学院学报,2018,43(9):1163-1165.[13]门晓亮,赵丽萍,杨杰,等.坤泰胶囊治疗围绝经期综合征的系统评价再评价[J].中国中药杂志,2021,46(19):5103-5109.[14]闫学花,杨玲,刘向娇,等.穴位电刺激联合耳穴贴压对围绝经期综合征患者免疫炎性反应和氧化应激的影响[J].河北医药,2020,42(7):1044-1046,1050.[15]左宏玲,邓燕,王艳芳,等.低剂量与标准剂量结合雌激素联合不同孕激素应用对围绝经期综合征患者骨密度的影响[J].中华妇产科杂志,2018,53(4):243-247.[16]李晓燕,王陶然,田喜慧.北京市海淀山后地区部分围绝经期女性围绝经期综合征及绝经激素治疗认知度的调查分析[J].山西医药杂志,2019,48(12):1404-1406.[17]张育强.小剂量戊酸雌二醇联合甲羟孕酮治疗围绝经期综合征患者的临床疗效[J].中国药物与临床,2020,20(18):3107-3108.[18]左宏玲,林守清,高晓黎,等.两种结合雌激素对围绝经期妇女雌激素水平及脂代谢影响多中心临床研究[J].中国实用妇科与产科杂志,2018,34(1):84-88.

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更新日期/Last Update: 1900-01-01