[1]胡晓丹,蒙 云,吕思娆,等.视频眼震电图扫视检查对帕金森病轻度认知障碍患者的诊断价值[J].医学信息,2025,38(03):85-90.[doi:10.3969/j.issn.1006-1959.2025.03.016]
　HU Xiaodan,MENG Yun,LYU Sirao,et al.Diagnostic Value of Video Nystagmography in Patients with Mild Cognitive Impairment in Parkinson′s Disease[J].Journal of Medical Information,2025,38(03):85-90.[doi:10.3969/j.issn.1006-1959.2025.03.016]
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视频眼震电图扫视检查对帕金森病轻度认知障碍患者的诊断价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年03期
页码:
85-90
栏目:
论著
出版日期:
2025-02-01

文章信息/Info

Title:
Diagnostic Value of Video Nystagmography in Patients with Mild Cognitive Impairment in Parkinson′s Disease
文章编号:
1006-1959（2025）03-0085-06
作者:
胡晓丹; 蒙 云; 吕思娆; 宁 茜
玉林市红十字会医院神经内科，广西 玉林 537000
Author(s):
HU Xiaodan;  MENG Yun;  LYU Sirao;  NING Qian
Department of Neurology, Yulin Red Cross Hospital, Yulin 537000, Jiangxi, China
关键词:
视频眼震电图; 扫视检查; 帕金森病; 轻度认知障碍
Keywords:
Video electronystagmogram;  Saccade inspection;  Parkinson′s disease;  Mild cognitive impairment
分类号:
R742.5
DOI:
10.3969/j.issn.1006-1959.2025.03.016
文献标志码:
A
摘要:
目的 分析视频眼震电图扫视检查诊断帕金森病轻度认知障碍的价值。方法 选取我院2021年2月-2023年12月收治的帕金森病患者60例，按照患者是否存在轻度认知障碍将其分成认知障碍组（n=30）与无认知障碍组（n=30），另外选取同期在我院接受体检的30例健康体检者，将其设为对照组；全部研究对象均接受视频眼震电图扫视检查，对检查结果进行分析比较，如扫视潜伏期、速度以及准确度。所有受试者均进行帕金森病认知功能评定量表（PD-CRS）、蒙特利尔认知评估量表（MoCA）评估，记录各项评分结果。多因素Logistic回归分析帕金森病轻度认知障碍的相关影响因素，并通过ROC分析对各指标单独诊断及联合诊断帕金森病轻度认知障碍的效能进行分析。结果 认知障碍组、无认知障碍组扫视潜伏期均长于对照组（P＜0.05），且认知障碍组扫视潜伏期长于无认知障碍组（P＜0.05）；认知障碍组、无认知障碍组扫视速度均低于对照组（P＜0.05），且认知障碍组扫视速度低于无认知障碍组（P＜0.05）；认知障碍组、无认知障碍组的扫视准确度低于对照组（P＜0.05），且认知障碍组扫视准确度低于无认知障碍组（P＜0.05）；认知障碍组、无认知障碍组MoCA、PD-CRS评分均低于对照组（P＜0.05），且认知障碍组MoCA、PD-CRS评分均低于无认知障碍组（P＜0.05）。多因素Logistic回归分析显示，扫视潜伏期延长、扫视速度缩短、扫视准确度下降与帕金森病轻度认知障碍的发生密切相关（P＜0.05）。各指标联合预测帕金森病轻度认知障碍的AUC最大，联合AUC与扫视潜伏、扫视速度、扫视准确度、MoCA评分、PD-CRS评分比较，差异有统计学意义（P＜0.05）。结论 帕金森病轻度认知障碍患者存在明显的眼球扫视运动障碍，视频眼震电图扫视检查不仅具有较高的可操作性，而且简单无创，通过视频眼震电图扫视检查联合PD-CRS、MoCA量表的联合诊断模型能对帕金森病轻度认知障碍进行早期准确诊断，进而为早期干预方案的制定提供指导，具有临床价值。
Abstract:
Objective To analyze the value of video nystagmography in the diagnosis of mild cognitive impairment in Parkinson′s disease. Methods A total of 60 patients with Parkinson′s disease admitted to our hospital from February 2021 to December 2023 were selected. According to whether the patients had mild cognitive impairment, they were divided into cognitive impairment group (n=30) and non-cognitive impairment group (n=30). In addition, 30 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group. All subjects were examined by video nystagmography, and the results were analyzed and compared, such as saccade latency, speed and accuracy. All subjects were assessed with Parkinson′s disease cognitive function rating scale (PD-CRS) and Montreal cognitive assessment scale (MoCA), and the scores were recorded. Multivariate Logistic regression analysis was used to analyze the related influencing factors of mild cognitive impairment in Parkinson ′s disease, and ROC analysis was used to analyze the efficacy of individual diagnosis and combined diagnosis of mild cognitive impairment in Parkinson’s disease. Results The saccade latency of the cognitive impairment group and the non-cognitive impairment group was longer than that of the control group (P<0.05), and the saccade latency of the cognitive impairment group was longer than that of the non-cognitive impairment group (P<0.05). The saccade speed of the cognitive impairment group and the non-cognitive impairment group was lower than that of the control group (P<0.05),and the saccade speed of the cognitive impairment group was lower than that of the non-cognitive impairment group (P<0.05). The saccade accuracy of the cognitive impairment group and the non-cognitive impairment group was lower than that of the control group (P<0.05), and the saccade accuracy of the cognitive impairment group was lower than that of the non-cognitive impairment group (P<0.05). The MoCA and PD-CRS scores of the cognitive impairment group and the non-cognitive impairment group were lower than those of the control group (P<0.05), and the MoCA and PD-CRS scores of the cognitive impairment group were lower than those of the non-cognitive impairment group (P<0.05). Multivariate Logistic regression analysis showed that prolonged saccade latency, shortened saccade speed and decreased saccade accuracy were closely related to the occurrence of mild cognitive impairment in Parkinson′s disease (P<0.05). The AUC of each index combined to predict mild cognitive impairment in Parkinson′s disease was the largest, and the combined AUC was compared with saccade latency, saccade speed, saccade accuracy, MoCA score and PD-CRS score, the difference was statistically significant (P<0.05). Conclusion Patients with mild cognitive impairment in Parkinson′s disease have obvious eye saccade movement disorders. Video nystagmography saccade examination not only has high operability, but also is simple and non-invasive. The combined diagnostic model of video nystagmography saccade examination combined with PD-CRS and MoCA scales can accurately diagnose mild cognitive impairment in Parkinson′s disease early, and then provide guidance for the formulation of early intervention programs, which has clinical value.

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更新日期/Last Update: 1900-01-01