[1]缪 华,楼迪栋.线粒体自噬与肾损伤理论探讨[J].医学信息,2025,38(03):179-183.[doi:10.3969/j.issn.1006-1959.2025.03.037]
 MIAO Hua,LOU Didong.Theoretical Exploration of Mitochondrial Autophagy and Renal Injury[J].Journal of Medical Information,2025,38(03):179-183.[doi:10.3969/j.issn.1006-1959.2025.03.037]
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线粒体自噬与肾损伤理论探讨()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年03期
页码:
179-183
栏目:
综述
出版日期:
2025-02-01

文章信息/Info

Title:
Theoretical Exploration of Mitochondrial Autophagy and Renal Injury
文章编号:
1006-1959(2025)03-0179-05
作者:
缪 华12楼迪栋123
1.贵州中医药大学基础医学院,贵州 贵阳 550000;2.贵州省法医中药毒理学特色重点实验室,贵州 贵阳 550000;3.贵州中医药大学司法鉴定所,贵州 贵阳 550000
Author(s):
MIAO Hua12 LOU Didong123
1.School of Medicine of Basic Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China;2.Guizhou Provincial Key Laboratory of Forensic Traditional Chinese Medicine Toxicology, Guiyang 550000, Guizhou, China;3.Judicial Authentication Institute of Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China
关键词:
线粒体自噬肾疾病肾损伤细胞死亡PINK1/Parkin通路
Keywords:
Mitochondrial autophagy Kidney disease Kidney injury Cell death PINK1/Parkin pathway
分类号:
R994
DOI:
10.3969/j.issn.1006-1959.2025.03.037
文献标志码:
A
摘要:
目前不明原因肾损伤患病率逐年上升,其死亡率也逐年增加,已经成为高度流行的疾病,不仅影响患者的生存质量,也给社会造成严重负担,而受损伤线粒体发生自噬时在肾疾病中也起重要调控作用并且极为关键。线粒体自噬通过清除受损、功能障碍的线粒体,同时减少活性氧积累达到保护肾小管上皮细胞作用,是生理和病理条件下线粒体质量控制的重要机制。因此,清除受损的线粒体对机体稳态和生存极为重要。本文旨在通过线粒体自噬相关途径寻求靶点调控以期为防治肾损伤、延缓其进入慢性肾脏病提供思路和策略。
Abstract:
At present, the prevalence of unexplained renal injury is increasing year by year, and its mortality rate is also increasing year by year. It has become a highly prevalent disease, which not only affects the quality of life of patients, but also causes a serious burden on society. Autophagy of damaged mitochondria also plays an important regulatory role and is critical in renal diseases. Mitochondrial autophagy protects renal tubular epithelial cells by removing damaged and dysfunctional mitochondria and reducing the accumulation of reactive oxygen species, which is an important mechanism for mitochondrial quality control under physiological and pathological conditions. Therefore, the removal of damaged mitochondria is extremely important for the body ’s homeostasis and survival. The purpose of this paper is to seek target regulation through mitophagy-related pathways in order to provide ideas and strategies for the prevention and treatment of renal injury and delay its entry into chronic kidney disease.

参考文献/References:

[1]王凌晨,王琛.基于线粒体功能障碍探讨中医药改善慢性肾脏病肾纤维化研究概况[J].中国中医药信息杂志,2023,30(1):170-175.[2]唐蜜,石永芳,肖珍,等.PINK1介导的线粒体自噬对大鼠骨髓内皮祖细胞衰老及其功能的影响[J].中国药理学通报,2022,38(10):1472-1480.[3]Carraro M,Bernardi P.The mitochondrial permeability transition pore in Ca2+ homeostasis[J].Cell Calcium,2023,111:102719.[4]Panisello-Roselló A,Lopez A,Folch-Puy E.Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update[J].World J Gastroenterol,2018,24(27):2984-2994.[5]Lu H,Li G,Liu L,et al.Regulation and function of mitophagy in de-velopment and cancer[J].Autophagy,2013,9(11):1720-1736.[6]Rabinovich-Nikitin I,Rasouli M,Reitz C,et al.Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress[J].Autophagy,2021,17(11):3794-3812.[7]Yu S,Du M,Yin A,et al.Bcl-xL inhibits PINK1/Parkin-dependent mitophagy by preventing mitochondrial Parkin accumulation[J].Int J Biochem Cell Biol,2020,122:105720.[8]Liang Q,Wan J,Liu H,et al.A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector[J].Autophagy,2023,19(2):616-631.[9]Yang B,Liu Q,Bi Y.Autophagy and apoptosis are regulated by stress on Bcl2 by AMBRA1 in the endoplasmic reticulum and mitochondria[J].Theor Biol Med Model,2019,16(1):18.[10]Lin Q,Li S,Jin H,et al.Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis[J].Int J Biol Sci,2023,19(4):1192-1210.[11]Meng L,Gao J,Mo W,et al.MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma[J].Redox Biol,2023,68:102956.[12]Ashkar F,Bhullar KS,Wu J.The Effect of Polyphenols on Kidney Disease: Targeting Mitochondria[J].Nutrients,2022,14(15):3115.[13]Sivitz WI,Yorek MA.Mitochondrial dys-function in diabetes: from molecular mecha-nisms to functional significance and thera-peutic opportunities[J].Antioxid Redox Signal,2010,12(4):537-577.[14]Zhao RZ,Jiang S,Zhang L,et al.Mitochondrial electron transport chain, ROS generation and uncoupling (Review)[J].Int J Mol Med,2019,44(1):3-15.[15]李轶男,裴汉军,余学文.远隔缺血预处理上调线粒体自噬减轻小鼠急性肾缺血再灌注损伤[J].智慧健康,2022,8(23):44-48.[16]Wolf P,Schoeniger A,Edlich F.Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane[J].Biochim Biophys Acta Mol Cell Res,2022,1869(10):119317.[17]Lysyk L,Brassard R,Arutyunova E.Insights into the catalytic properties of the mitochondrial rhomboid protease PARL[J].J Biol Chem,2021,296:100383.[18]廖金花,王兴,王晓琳,等.真武汤对慢性心力衰竭大鼠PINK1/parkin介导线粒体自噬的作用研究[J].中国中医基础医学杂志,2025,31(1):43-48.[19]Wang Y,Dai X,Li H,et al.The role of mitochondrial dynamics in disease[J].Med Comm,2023,4(6):e462.[20]王孙萍,代培,胡浩,等.基于PINK1/Parkin通路介导的线粒体自噬探讨泛酸对糖尿病肾病小鼠的影响[J].新疆医科大学学报,2023.46(8):991-996[21]Di Rienzo M,Romagnoli A,Ciccosanti F,et al.AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability[J].Autophagy,2022,18(8):1752-1762.[22]Yao RQ,Ren C,Xia ZF.Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles[J].Autophagy,2021,17(2):385-401.[23]Tang C,Han H,Yan M,et al.PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury[J].Autophagy,2018,14(5):880-897.[24]Wang Y,Cai J,Tang C,et al.Mitophagy in Acute Kidney Injury and Kidney Repair[J].Cells,2020,9(2):338.[25]Liu T,Yang Q,Zhang X,et al.Quercetin alleviates kidneyfibrosis by reducing renal tubular epithelial cell senescencethrough the SIRT1/PINK1/mitophagy axis[J].Life Sci,2020,257:118116.[26]Dai XG,Xu W,Li T,et al.Involvement of phosphatase and tensin homolog- induced putative kinase 1- Parkin- mediated mitophagy in septic acute kidney injury[J].Chin Med J,2019,132(19):2340-2347[27]胡彦,王锁刚,翟琼瑶,等.积雪草苷调控SIRT1-FOXO3-PINK1-Parkin通路介导的线粒体自噬保护肾缺血再灌注损伤的机制研究[J].天津医药,2021,49(11):1148-1153.[28]Fu ZJ,Wang ZY,Xu L,et al.HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury[J].Redox Biol,2020,36:101671.[29]Fujimura R,Yamamoto T,Takabatake Y,et al.Autophagy protects kidney from phosphate-induced mitochondrial injury[J].Biochem Biophys Res Commun,2020,524(3):636-642.[30]Kawakami T,Gomez IG,Ren S,et al.Deficient Autophagy Results in Mitochondrial Dysfunction and FSGS[J].J Am Soc Nephrol,2015,26(5):1040-1052.[31]Cui J,Shi S,Sun X,et al.Mitochondrial autophagy involving renal injury and aging is modulated by caloric intake in aged rat kidneys[J].PLoS One,2013,8(7):69720.

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更新日期/Last Update: 1900-01-01