[1]牛旭东,牛晓霞.不同孕妇妊娠各期血清甲状腺激素及TPO-Ab水平变化及其相关性研究[J].医学信息,2025,38(07):82-86.[doi:10.3969/j.issn.1006-1959.2025.07.014]
　NIU Xudong,NIU Xiaoxia.Study on the Changes and Correlation of Serum Thyroid Hormone and TPO-Ab Levels in Different Pregnant Women During Pregnancy Periods[J].Journal of Medical Information,2025,38(07):82-86.[doi:10.3969/j.issn.1006-1959.2025.07.014]
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不同孕妇妊娠各期血清甲状腺激素及TPO-Ab水平变化及其相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年07期
页码:
82-86
栏目:
论著
出版日期:
2025-04-01

文章信息/Info

Title:
Study on the Changes and Correlation of Serum Thyroid Hormone and TPO-Ab Levels in Different Pregnant Women During Pregnancy Periods
文章编号:
1006-1959（2025）07-0082-05
作者:
牛旭东; 牛晓霞
银川市妇幼保健院内科，宁夏 银川 750001
Author(s):
NIU Xudong;  NIU Xiaoxia
Department of Internal Medicine, Yinchuan Maternal and Child Health Hospital, Yinchuan 750001, Ningxia, China
关键词:
妊娠; 亚临床甲状腺功能减退; 甲状腺激素; TPO-Ab
Keywords:
Pregnancy;  Subclinical hypothyroidism;  Thyroid hormone;  TPO-Ab
分类号:
R714.1
DOI:
10.3969/j.issn.1006-1959.2025.07.014
文献标志码:
A
摘要:
目的 探讨不同孕妇不同妊娠周期血清甲状腺激素水平的差异及其和甲状腺过氧化物酶抗体（TPO-Ab）的相关性。方法 回顾性选取我院2022年5月-2023年5月收治的110例正常孕妇为正常孕产组，78例妊娠合并亚临床甲状腺功能减退（SCH）为亚甲减孕产组，100例无妊娠健康女性为无妊娠对照组，检测两组孕产组和无妊娠对照组血清甲状腺激素[促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺激素（FT4）]、TPO-Ab水平，分析血清甲状腺激素与TPO-Ab阳性的相关性。结果 与无妊娠对照组比较，正常孕产组TSH较低，亚甲减孕产组TSH较高，两组妊娠组FT4、FT3均低于无妊娠对照组，亚甲减孕产组TPO-Ab高于无妊娠对照组（P均＜0.05）；亚甲减孕产组TSH、TPO-Ab均高于正常孕产组（P＜0.05），FT4、FT3略低于正常孕产组，但差异无统计意义（P＞0.05）；正常孕产组不同孕期比较：TSH：孕早期＜孕中期＜孕晚期（P＜0.05），呈上升趋势；正常孕产组不同孕期FT4、FT3：孕早期＞孕中期＞孕晚期，呈下降趋势（P＜0.05）；不同孕期TPO-Ab比较，差异无统计学意义（P＞0.05）；亚甲减孕产组不同孕期比较：TSH：孕早期＜孕中期＜孕晚期（P＜0.05），呈上升趋势；孕产组不同孕期FT4、FT3呈下降趋势，FT3孕早期＞孕中期＞孕晚期（P＜0.05），不同孕期FT4比较，差异无统计学意义（P＞0.05）；不同孕期TPO-Ab比较，差异有统计学意义（P＜0.05）。亚甲减孕产组78例，TPO-Ab阳性率73.08%，血清TSH水平与TPO-Ab阳性率呈正相关（r=0.409，P＜0.05），血清FT3与TPO-Ab阳性率呈负相关（r=-0.256，P＜0.05），FT4水平与TPO-Ab阳性率无相关（r=-0.077，P＞0.05）。结论 妊娠孕产妇不同孕期血清甲状腺激素水平变化具有规律性，妊娠合并SCH孕产妇血清FT3、TSH水平与TPO-Ab阳性率密切相关。
Abstract:
Objective To investigate the difference of serum thyroid hormone levels in different pregnant women during different pregnancy periods and its correlation with thyroid peroxidase antibody (TPO-Ab). Methods Retrospectively selected 110 normal pregnant women admitted to our hospital from May 2022 to May 2023 as normal pregnancy group, 78 pregnant women with subclinical hypothyroidism (SCH) as subclinical hypothyroidism pregnancy group, and 100 non-pregnant healthy women as non-pregnant control group. The levels of serum thyroid hormones [thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroid hormone (FT4)] and TPO-Ab in the two groups of pregnant women and non-pregnant control group were detected, and the correlation between serum thyroid hormones and TPO-Ab positive was analyzed. Results Compared with the non-pregnancy control group, TSH in the normal pregnancy group was lower, and TSH in the subclinical hypothyroidism group was higher. FT4 and FT3 in the two pregnancy groups were lower than those in the non-pregnancy control group, and TPO-Ab in the subclinical hypothyroidism group was higher than that in the non-pregnancy control group (all P<0.05). TSH and TPO-Ab in the subclinical hypothyroidism group were higher than those in the normal pregnancy group (P<0.05), FT4 and FT3 were slightly lower than those in the normal pregnancy group, but the difference was not statistically significant (P>0.05). Comparison of different pregnancy periods in normal pregnancy group: TSH: early pregnancymiddle pregnancy>late pregnancy, showing a downward trend (P<0.05); Comparison of different pregnancy periods in the subclinical hypothyroidism group: TSH: early pregnancymiddle pregnancy>late pregnancy (P<0.05), there was no significant difference in FT4 at different pregnancy periods in the pregnant group (P>0.05), but the difference of TPO-Ab at different pregnancy periods was statistically significant (P<0.05). The positive rate of TPO-Ab was 73.08% in 78 pregnant women with subclinical hypothyroidism, serum TSH levelO-Ab positive rate (r=0.409, P<0.05), serum FT3 level was negatively correlated with TPO-Ab positive rate (r=-0.256, P<0.05), and there was no correlation between FT4 level and TPO-Ab positive rate (r=-0.077, P>0.05). Conclusion The changes of serum thyroid hormone levels in pregnant women during different pregnancy periods are regular. The levels of serum FT3 and TSH in pregnant women with SCH are closely related to the positive rate of TPO-Ab.

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更新日期/Last Update: 1900-01-01