[1]郭龙芳,钟 珊.拉贝洛尔片联合硫酸镁治疗对妊娠高血压综合征孕妇脐血流指数及母婴预后的影响[J].医学信息,2026,39(10):131-134,139.[doi:10.3969/j.issn.1006-1959.2026.10.023]
　GUO Longfang,ZHONG Shan.Effects of Labetalol Tablets Combined with Magnesium Sulfate on Umbilical Cord Blood Flow Indexes and Maternal-Infant Outcomes in Patients with Pregnancy-induced Hypertension Syndrome[J].Journal of Medical Information,2026,39(10):131-134,139.[doi:10.3969/j.issn.1006-1959.2026.10.023]
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拉贝洛尔片联合硫酸镁治疗对妊娠高血压综合征孕妇脐血流指数及母婴预后的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年10期
页码:
131-134,139
栏目:
临床证据信息
出版日期:
2026-05-15

文章信息/Info

Title:
Effects of Labetalol Tablets Combined with Magnesium Sulfate on Umbilical Cord Blood Flow Indexes and Maternal-Infant Outcomes in Patients with Pregnancy-induced Hypertension Syndrome
文章编号:
1006-1959（2026）10-0131-05
作者:
郭龙芳; 钟 珊
兴国县妇幼保健院妇产科，江西 兴国 342400
Author(s):
GUO Longfang;  ZHONG Shan
Department of Obstetrics and Gynecology, Xingguo County Maternal and Child Health Hospital, Xingguo 342400, Jiangxi, China
关键词:
拉贝洛尔片; 硫酸镁; 妊娠高血压综合征; 脐血流指数; 母婴预后
Keywords:
Labetalol tablets;  Magnesium sulfate;  Pregnancy-induced hypertension syndrome;  Umbilical cord blood flow indexes;  Maternal-infant outcomes
分类号:
R714.2
DOI:
10.3969/j.issn.1006-1959.2026.10.023
文献标志码:
A
摘要:
目的 评估妊娠高血压综合征治疗过程中拉贝洛尔片+硫酸镁的应用效果及对孕妇脐血流指数及母婴预后的影响。方法 采用随机数字表法将我院2023年4月-2025年3月诊治的56例妊娠高血压综合征孕妇分为对照组28例和治疗组28例。对照组以硫酸镁治疗，治疗组在对照组基础上联合拉贝洛尔片治疗，对比两组孕妇脐血流指数（脐动脉血流速度峰谷比、脐动脉阻力指数）、血压指标（收缩压、舒张压）、母婴预后、血压恢复时间、24h尿蛋白定量、不良反应发生率。结果 两组脐动脉血流速度峰谷比、脐动脉阻力指数均小于治疗前，且治疗组小于对照组（P＜0.05）；两组收缩压、舒张压均低于治疗前，且治疗组低于对照组（P＜0.05）；治疗组不良妊娠结局总发生率（10.71%）低于对照组（25.00%）（P＜0.05）；治疗组血压恢复时间短于对照组，24h尿蛋白定量低于对照组（P＜0.05）；治疗组（7.14%）与对照组（10.71%）不良反应发生率相比无差异（P＞0.05）。结论 拉贝洛尔片联合硫酸镁治疗妊娠高血压综合征的效果理想，可降低脐血流指数、脐动脉阻力指数及血压水平，改善母婴预后，且未增加不良反应，安全性良好，值得临床加以应用。
Abstract:
Objective To investigate the effects of labetalol tablets combined with magnesium sulfate on umbilical cord blood flow indexes and maternal-infant outcomes in pregnancy-induced hypertension syndrome. Methods A total of 56 pregnant women with pregnancy-induced hypertension syndrome who were treated in our hospital from April 2023 to March 2025 were selected as the research objects. They were divided into control group and treatment group by random number table method, with 28 pregnant women in each group. The control group was treated with magnesium sulfate, and the treatment group was treated with labetalol tablets on the basis of the control group. The umbilical cord blood flow indexes (peak-to-valley ratio of umbilical artery blood flow velocity, umbilical artery resistance index), blood pressure indexes (systolic blood pressure, diastolic blood pressure), maternal-infant outcomes, blood pressure recovery time, 24 h urine protein quantification, and incidence of adverse reactions were compared between the two groups. Results The peak-to-valley ratio of umbilical artery blood flow velocity and umbilical artery resistance index in the two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P<0.05). The systolic blood pressure and diastolic blood pressure in the two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group (P<0.05). The total incidence of adverse pregnancy outcomes in the treatment group was lower than that in the control group (10.71% vs. 25.00%) (P<0.05). The recovery time of blood pressure in the treatment group was shorter than that in the control group, and the 24 h urine protein was lower than that in the control group (P<0.05). There was no difference in the incidence of adverse reactions between the treatment group (7.14%) and the control group (10.71%) (P>0.05). Conclusion Labetalol tablets combined with magnesium sulfate is effective in the treatment of pregnancy-induced hypertension syndrome, which can reduce umbilical cord blood flow indexes, umbilical artery resistance indexes and blood pressure levels, improve maternal-infant outcomes, and has no significant adverse reactions. It is safe and worthy of clinical application.

参考文献/References:

[1]沈晓苗,陆竹梅,邓姗,等.硝苯地平、酚妥拉明及硫酸镁联合治疗对妊娠期高血压综合征患者血流动力学及血管内皮功能的影响[J].新疆医学,2021,51(8):908-910.[2]林敏.硫酸镁与硝苯地平联合治疗妊娠期高血压综合征的有效性[J].中国社区医师,2021,37(17):39-40.[3]吴海艳,刘嗣超.硫酸镁与硝苯地平结合在妊娠期高血压综合征中的治疗效果及对脐血流指数、核糖核酸酶抑制因子的影响[J].贵州医药,2022,46(2):192-193.[4]王静静.拉贝洛尔、硝苯地平、硫酸镁联合治疗妊娠期高血压综合征的疗效及对炎性因子的影响研究[J].数理医药学杂志,2022,35(7):1060-1063. [5]陈英.硫酸镁联合硝苯地平对妊娠期高血压疾病患者血压及妊娠结局的影响[J].包头医学,2020,45(3):5-7.[6]王煜,张晓娜.硫酸镁注射液联合硝苯地平治疗对妊娠期高血压 综合征患者血液流变学及炎性因子的影响分析[J].贵州医药,2022,46(11):1759-1760.[7]马梓汶,庄伯乐,奚杰,等.孕前体质指数和孕期增重速率与妊娠期高血压疾病的相关性[J].中国妇幼保健,2023,38(2):201-204.[8]中华医学会妇产科学分会妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南(2020)[J].中华妇产科杂志,2020,55(4):227-238.[9]陈洁,仇春波,罗琪.硫酸镁酚妥拉明及硝苯地平联合治疗对妊娠期高血压疾病孕妇血压变化妊娠结局及不良反应的影响[J].中国妇幼保健,2021,36(10):2220-2224.[10]午庆玲,赵婷,王彰勇,等.孕妇妊娠期高血压疾病发生危险因素及疾病严重程度对妊娠结局影响[J].临床军医杂志,2023,51(3):288-290,293.[11]徐雪莉,杨宝玲.硫酸镁联合硝苯地平对妊娠期高血压疾病患者凝血功能及妊娠结局的影响[J].血栓与止血学,2022,28(2):264-265,267.[12]马静,霍飞霞,王征.硝苯地平联合硫酸镁治疗妊娠期高血压及母婴结局[J].西北药学杂志,2023,38(2):143-146.[13]王永红,卢爱军,刘春光,等.参芎注射液联合硫酸镁和拉贝洛尔治疗妊娠期高血压的临床疗效观察[J].世界中医药,2020,16(6):883-886,891.[14]陈小琳,慕婷,雷洁.血肾损伤分子1与β2微球蛋白浓度在妊娠期高血压并发早期肾损伤的诊断价值[J].中国综合临床,2020,36(3):263-266.[15]许靖宁,徐琳,刘进军.拉贝洛尔联合硫酸镁对妊娠期高血压的治疗效果及对分娩结局的影响[J].实用临床医药杂志,2020,24(20):87-89,93.[16]王子宏,周婷婷.硝苯地平联合拉贝洛尔治疗妊娠期高血压疗效及对血清脂联素水平和血液黏度的影响[J].中国计划生育学杂志,2022,30(7):1577-1581.[17]周立娜,张蕾,孙晓娜,等.妊娠期高血压疾病患者凝血功能指标,血小板参数和血清钙离子浓度的变化及意义[J].河北医药,2022,44(12):1851-1854.[18]欧周芬,章莉荔.硫酸镁联合硝苯地平治疗妊娠期高血压疾病临床疗效[J].深圳中西医结合杂志,2022,32(21):118-120.[19]晁代永.拉贝洛尔片联合硝苯地平片治疗妊娠高血压的效果及对患者生化指标和妊娠结局的影响[J].中国药物经济学,2020,15(4):31-34.[20]张卫新.拉贝洛尔联合硫酸镁对妊娠期高血压疾病患者血清NO、ET-1水平及妊娠结局的影响分析[J].现代诊断与治疗,2021,32(21):3368-3370.

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更新日期/Last Update: 1900-01-01