[1]谭新沙,杨 艳,席红琳.GnRHa降调节联合人工周期方案在反复植入失败患者中的 应用研究[J].医学信息,2018,31(14):88-91.[doi:10.3969/j.issn.1006-1959.2018.14.025]
　TAN Xin-sha,YANG Yan,XI Hong-lin.Application of GnRHa Descending Regulation Combined with Artificial Cycle in Patients with Recurrent Implantation Failure[J].Journal of Medical Information,2018,31(14):88-91.[doi:10.3969/j.issn.1006-1959.2018.14.025]
点击复制

GnRHa降调节联合人工周期方案在反复植入失败患者中的 应用研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年14期
页码:
88-91
栏目:
论著
出版日期:
2018-07-15

文章信息/Info

Title:
Application of GnRHa Descending Regulation Combined with Artificial Cycle in Patients with Recurrent Implantation Failure
文章编号:
1006-1959（2018）14-0088-04
作者:
谭新沙; 杨 艳; 席红琳
三峡大学附属仁和医院生殖中心，湖北 宜昌 443000
Author(s):
TAN Xin-sha; YANG Yan; XI Hong-lin
Reproductive Center,Renhe Hospital,Sanxia University,Yichang 443000,Hubei,China
关键词:
促性腺激素释放激素激动剂; 胚胎反复植入失败; 冻融胚胎周期; 人工周期
Keywords:
Key words：Gonadotropin-releasing hormone agonist; Recurrent embryo implantation failure; Freeze-thaw embryo cycle; Artificial cycle
分类号:
R717
DOI:
10.3969/j.issn.1006-1959.2018.14.025
文献标志码:
A
摘要:
目的 探讨GnRHa降调节联合人工周期方案对反复植入失败后冻融胚胎移植妊娠结局的影响。方法 对170例胚胎反复植入失败患者的解冻胚胎移植周期进行回顾性分析，根据内膜准备方案的不同分为两组。A组90例GnRHa降调节联合人工周期组，B组80例人工周期组，分别比较两组在黄体酮转化日内膜厚度、类型、血清雌二醇水平以及移植胚胎数、优胚数、优胚率、临床妊娠率、异位妊娠率、多胎率、早期流产率。结果 A组与B组患者在黄体酮转化日内膜的厚度、移植胚胎数、优质胚胎数、优质胚胎率、多胎率、异位妊娠率及早期流产率，差异无统计学意义(P＞0.05)；A组患者黄体酮转化日血清雌二醇水平低于B组，差异有统计学意义(P＜0.05)；两组患者内膜分型比较，差异无统计学意义(P＞0.05),但降调节联合人工周期组患者A型内膜的比例较人工周期组高；A组患者的临床妊娠率为56.67%高于B组42.50%,差异有统计学意义(P＜0.05)。结论 GnRHa降调节联合人工周期方案可改善反复植入失败后冻融胚胎移植的妊娠率。
Abstract:
Abstract：Objective To investigate the effect of GnRHa descending regulation combined with artificial cycle on the outcome of frozen-thawed embryo transfer after recurrent implantation failure.Methods 170 cases of thawed embryo transfer were analyzed retrospectively.According to the different plans of endometrial preparation,in group A there were 90 cases of GnRHa descending regulation combined with artificial cycle group,and in group B there were 80 cases of artificial cycle.The diurnal thickness, type, serum estradiol level of the two groups and the number of transplanted embryos, optimal embryo number,optimal embryo rate,clinical pregnancy rate,ectopic pregnancy rate,multiple fetal rate and early abortion rate were compared respectively.Results There was no significant difference between group A and group B in the diurnal thickness of progesterone,the number of embryos transplanted,the number of high quality embryos,high quality embryo rate,multiple fetal rate,ectopic pregnancy rate and early abortion rate(P>0.05).The serum estradiol level in group A was lower than that in group B on the day of progesterone conversion,the difference was statistically significant(P<0.05).There was no significant difference in endometrial classification between the two groups(P>0.05),but the proportion of type A intima in patients with downregulation combined with artificial cycle group was higher than that of artificial cycle group. The clinical pregnancy rate of patients in group A was 56.67% higher than that in group B 42.50%,and the difference was statistically significant(P<0.05).Conclusion GnRHa combined with artificial cycle regimen can improve the pregnancy rate of frozen and thawed embryo transfer after recurrent implantation failure.

参考文献/References:

[1]Goden Y,Casper RF.Prediction of implantation by the sonographic appearance of the endometrium during controlled ovarian stimulation for IVF[J].In vitro fertilization embryo transfer,1990,7(3):146-152. [2]Opien HK,Fedorcsak P,Omland AK,et al.Invitro fertilization is a successful treatment in endometriosis-associated infertility[J].Fertility&Sterility,2012,97(4):912-918. [3]祁静,腊晓琳.反复种植失败的相关对策新进展[J].中华生殖与避孕杂志,2014(2):149-154. [4]张波,颜军昊.胚胎反复着床失败的病因及处理措施[J].中华生殖与避孕杂志,2014,34(7):564-570. [5]Groenewoud ER,Cantineau AE,Kollen BJ,et al.What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles A systematic review and meta-analysis[J]. Human Reproduction Update,2013,19(5):458-470. [6]江成龙,张昌军.降调节与非降调节激素替代内膜准备对冻融胚胎移植结局的影响[J].现代妇产科进展,2015(6):441-443. [7]Groenewoud ER,Cantineau AE,Kollen BJ,et al.What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles A systematic review and meta-analysis[J].Human Reproduction Update,2013,19(5):458-470. [8]东亚君,李玉艳,李敏,等.GnRH-a预处理在冻融胚胎移植中的价值[J].第三军医大学学报,2014,36(15):1619-1622. [9]Nekoo EA,Chamani M,Tehrani ES,et al.Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses[J].Journal of Family&Reproductive Health,2015,9(1):1-4. [10]程婷婷,孙莹璞,苏迎春,等.降调节联合人工周期方案在冻融胚胎移植周期中的应用[J].生殖与避孕,2013,33(3):167-172.

相似文献/References:

[1]熊永崂,孙晓燕,聂晓莉,等.卵泡期半量长方案在反复种植失败患者再次行IVF-ET治疗中的疗效[J].医学信息,2022,35(14):116.[doi:10.3969/j.issn.1006-1959.2022.14.028]
　XIONG Yong-lao,SUN Xiao-yan,NIE Xiao-li,et al.Efficacy of Follicular Half-dose Long Protocol in Repeated IVF-ET for Patients with Failed Implantation[J].Journal of Medical Information,2022,35(14):116.[doi:10.3969/j.issn.1006-1959.2022.14.028]

更新日期/Last Update: 2018-07-15