[1]王淑娟,林祥灿.血浆NT-proBNP水平与同型半胱氨酸对 糖尿病合并心房颤动的相关性研究[J].医学信息,2018,31(14):169-171.[doi:10.3969/j.issn.1006-1959.2018.14.053]
　WANG Shu-juan,LIN Xiang-can.Correlation between Plasma NT-proBNP level and Homocysteine in Patients with Diabetes Mellitus Complicated with Atrial Fibrillation[J].Journal of Medical Information,2018,31(14):169-171.[doi:10.3969/j.issn.1006-1959.2018.14.053]
点击复制

血浆NT-proBNP水平与同型半胱氨酸对 糖尿病合并心房颤动的相关性研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年14期
页码:
169-171
栏目:
诊疗技术
出版日期:
2018-07-15

文章信息/Info

Title:
Correlation between Plasma NT-proBNP level and Homocysteine in Patients with Diabetes Mellitus Complicated with Atrial Fibrillation
文章编号:
1006-1959（2018）14-0169-03
作者:
王淑娟; 林祥灿
海洋石油总医院心内科，天津 300452
Author(s):
WANG Shu-juan; LIN Xiang-can
Department of Cardiology,Ocean Petroleum General Hospital,Tianjin 300452,China
关键词:
糖尿病; 心房颤动; 血浆NT-proBNP; 同型半胱氨酸
Keywords:
Key words：Diabetes mellitus; Atrial fibrillation; Plasma NT-proBNP; Homocysteine
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2018.14.053
文献标志码:
A
摘要:
目的 探讨2型糖尿病合并心房颤动患者血N末端B型利钠肽原水平与同型半胱氨酸相关性。方法 选取2016年1月~2017年1月在我院接受治疗的T2DM患者120例，根据其有无心房颤动将患者分为房颤组(48例)和无房颤组（72例），所有患者均采用全自动生化分析仪检测血浆NT-proBNP及Hcy的水检测，观察两组血浆NT-proBNP水平与同型半胱氨酸的相关性。结果 观察组血浆NT-proBNP、Hcy均高于对照组，差异有统计学意义（P＜0.05）；观察组血浆NT-proBNP水平与Hcy呈正相关(r=0.328，P＜0.05)；两组间LAD、LVDD、LVEF、糖尿病病程相比较，差异无统计学意义(P＞0.05)。房颤组血浆NT-proBNP水平、Hcy高于无房颤组，差异有统计学意义（P＜0.05），血浆NT-proBNP水平与Hcy呈正相关(r=0.328，P＜0.05)。结论血浆NT-proBNP、Hcy为糖尿病并发房颤的危险因素。可通过联合检测血浆NT-proBNP及Hcy的水平预知糖尿病发生房颤的可能。
Abstract:
Abstract：Objective To investigate the relationship between plasma N-terminal type B natriuretic peptide and homocysteine in patients with type 2 diabetes mellitus complicated with atrial fibrillation.Methods 120 patients with T2DM who were treated in our hospital from January 2016 to January 2017 were selected.Patients were divided into atrial fibrillation group(n=48)and non-atrial fibrillation group(n=72)according to their presence or absence of atrial fibrillation.The plasma NT-proBNP and Hcy were detected by automatic biochemical analyzer,and the correlation between plasma NT-proBNP and homocysteine was observed.Results The plasma NT-proBNP and Hcy levels in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05),the plasma NT-proBNP level in the observation group was positively correlated with Hcy(r=0.328,P< 0.05),there was no significant difference in the duration of LAD,LVDD,LVEF and diabetes between the two groups(P>0.05).The plasma NT-proBNP level and Hcy in the atrial fibrillation group were higher than those in the non atrial fibrillation group,the difference was statistically significant(P<0.05),and the plasma NT-proBNP level was positively correlated with Hcy(r=0.328,P<0.05). Conclusion Plasma NT-proBNP and Hcy are risk factors for diabetes mellitus complicated with atrial fibrillation.The possibility of atrial fibrillation in diabetes can be predicted by combined detection of plasma NT-proBNP and Hcy levels.

参考文献/References:

[1]Hobbs FR,Taylor CJ,JanGeersing G,et al.European Primary CareCardiovascular Society（EPCCS）consensus guidance on strokeprevention in atrial fibrillation（SPAF）in primary care[J].EurJPrev Cardiol,2016,23(5):460-473. [2]Ponikowski P,Voors AA,Anker SD,et al.2016ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure[J].Engl Ed,2016,69(12):1167. [3]Streb W,Mitrga K,Szymaa M,et al.The intracardiac concentrations of the N-terminal-pro B-type natriuretic peptide (NT-proBNP)and the determinants of its secretion in patients with atrial fibrillation[J].Kardiol Pol,2018,76(2):433-439. [4]Guasch E,Mont L,Sitges M,et al.Mechanisms of atrial fibrillation in athletes:what we know and what we do not know[J].Neth Heart J,2018,26(3):133-145. [5]Huxley RR,Filion KB,Konety S,et al.Meta-analysis of cohort andcase-control studies of type 2 diabetes mellitus and risk of atrial fibrillation[J].Am J Cardiol,2011(108):56-62. [6]Hu WS,Lin CL.Role of CHA2DS2-VASc score in predicting new-onset atrial fibrillation in patients with type 2 diabetes mellitus with and without hyperosmolar hyperglycaemic state: real-world data from a nationwide cohort[J].BMJ Open,2018,8(3):e020065. [7]Svennberg E,Henriksson P,Engdahl J,et al.N-terminal pro B-type natriuretic peptide in systematic screening for atrial fibrillation[J].Heart,2017,103(16):1271-1277. [8]Mearns B M.Prevention:BNP screening and collaborative care can help to prevent heart failure[J].Nature Reviews Cardiology,2013,10(9):489. [9]Mark Ledwidge,Joseph Gallagher,Carmel Conlon,et al.Natriuretic Peptide-Based Screening and Collaborative Care for Heart Failure:The STOP-HF Randomized Trial[J].JAMA:the Journal of the American Medical Association,2013,310(1):66-74. [10]FromonotJ,DeharoP,BruzzeseL,et al.Adenosine plasma levelcorrelates with homoeysteine and uric acid concentrations inpatients with coronary artery disease[J].Can J PhysiolPharmacol,2016,94(3):272-277. [11]Gong T,WangJ,YangM,et al.Serum homocysteine level andgestational diabetes mellitus:Ameta.analysis[J].J DiabetesInvestig,2016,7(4):622-628. [12]孙小军,卢京.美托洛尔联合曲美他嗪治疗冠心病心力衰竭的临床疗效观察[J].中国医院用药评价与分析,2015,15(3):312-314.

相似文献/References:

[1]张西园.糖尿病与结直肠癌患者预后相关研究进展[J].医学信息,2018,31(01):55.[doi:10.3969/j.issn.1006-1959.2018.01.020]
　ZHANG Xi-yuan.Research Progress in the Relationship between Diabetes and the Prognosis of Colorectal Cancer[J].Journal of Medical Information,2018,31(14):55.[doi:10.3969/j.issn.1006-1959.2018.01.020]
[2]耿金萍.综合护理对甲状腺良性肿瘤并糖尿病患者手术效果的影响分析[J].医学信息,2018,31(01):163.[doi:10.3969/j.issn.1006-1959.2018.01.064]
　GENG Jin-ping.Analysis of the Effect of Comprehensive Nursing on the Surgical Effect of Thyroid Benign Tumor and Diabetic Patients[J].Journal of Medical Information,2018,31(14):163.[doi:10.3969/j.issn.1006-1959.2018.01.064]
[3]李雯婷,谈世华,余江明,等.踝肱指数检测在住院糖尿病患者中的重复性研究[J].医学信息,2018,31(03):159.[doi:10.3969/j.issn.1006-1959.2018.03.058]
　LI Wen-ting,TAN Shi-hua,YU Jiang-ming,et al.Study on Reproducibility of Ankle-brachial Index in Inpatients with Diabetes Mellitus[J].Journal of Medical Information,2018,31(14):159.[doi:10.3969/j.issn.1006-1959.2018.03.058]
[4]刘 静.冠状动脉粥样硬化性心脏病合并糖尿病的血脂检验结果分析[J].医学信息,2018,31(04):154.[doi:10.3969/j.issn.1006-1959.2018.04.057]
　LIU Jing.Analysis of Blood Lipid Test Results in Coronary Atherosclerotic Heart Disease Complicated with Diabetes Mellitus[J].Journal of Medical Information,2018,31(14):154.[doi:10.3969/j.issn.1006-1959.2018.04.057]
[5]谢勇丽,苏晓清,张雅薇.糖尿病痛性周围神经病变患者情绪调查分析[J].医学信息,2018,31(05):14.[doi:10.3969/j.issn.1006-1959.2018.05.005]
　XIE Yong-li,SU Xiao-qing,ZHANG Ya-wei.Investigation and Analysis of Mood in Patients with Diabetic Peripheral Neuropathy[J].Journal of Medical Information,2018,31(14):14.[doi:10.3969/j.issn.1006-1959.2018.05.005]
[6]张雅薇,朱明慧.首发为动眼神经麻痹的糖尿病合并动眼神经麻痹误诊为痛性眼肌麻痹1例分析[J].医学信息,2018,31(05):23.[doi:10.3969/j.issn.1006-1959.2018.05.008]
　ZHANG Ya-wei,ZHU Ming-hui.An Analysis of a Case of Diabetes Mellitus with Oculomotor Nerve Palsy Misdiagnosed as Painful Ophthalmoplegia[J].Journal of Medical Information,2018,31(14):23.[doi:10.3969/j.issn.1006-1959.2018.05.008]
[7]张宇宁.黄酮类化合物治疗糖尿病及其并发症的研究[J].医学信息,2018,31(05):50.[doi:10.3969/j.issn.1006-1959.2018.05.018]
　ZHANG Yu-ning.Study on Flavonoids in the Treatment of Diabetes Mellitus and its Complications[J].Journal of Medical Information,2018,31(14):50.[doi:10.3969/j.issn.1006-1959.2018.05.018]
[8]柳 梅.头孢哌酮钠舒巴坦钠治疗糖尿病并发尿路感染的 临床效果观察[J].医学信息,2018,31(07):139.[doi:10.3969/j.issn.1006-1959.2018.07.047]
　LIU Mei.Clinical Efficacy of Cefoperazone Sodium and Sulbactam Sodium in Treatment of Diabetes Complicated with Urinary Tract Infection[J].Journal of Medical Information,2018,31(14):139.[doi:10.3969/j.issn.1006-1959.2018.07.047]
[9]吕桂英.影响糖尿病患者药物治疗依从性相关因素临床分析[J].医学信息,2018,31(08):109.[doi:10.3969/j.issn.1006-1959.2018.08.036]
　LV Gui-ying.Clinical Analysis of Factors Related to Compliance with Drug Therapy in Patients with Diabetes Mellitus[J].Journal of Medical Information,2018,31(14):109.[doi:10.3969/j.issn.1006-1959.2018.08.036]
[10]刘爱君.糖化血红蛋白测定在糖尿病诊断中的应用价值分析[J].医学信息,2018,31(08):161.[doi:10.3969/j.issn.1006-1959.2018.08.057]
　LIU Ai-jun.Analysis of the Value of Determination of Glycosylated Hemoglobin in the Diagnosis of Diabetes Mellitus[J].Journal of Medical Information,2018,31(14):161.[doi:10.3969/j.issn.1006-1959.2018.08.057]

更新日期/Last Update: 2018-07-15