[1]李跃飞,郑晶晶,于聪祥.干细胞标记物Musashi-1与子宫内膜异位症关系的研究进展[J].医学信息,2018,31(23):48-50.[doi:10.3969/j.issn.1006-1959.2018.23.014]
 LI Yue-fei,ZHENG Jing-jing,YU Cong-xiang.Advances in Research on the Relationship between Cell Marker Musashi-1 and Endometriosis[J].Journal of Medical Information,2018,31(23):48-50.[doi:10.3969/j.issn.1006-1959.2018.23.014]
点击复制

干细胞标记物Musashi-1与子宫内膜异位症关系的研究进展()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年23期
页码:
48-50
栏目:
综述
出版日期:
2018-12-01

文章信息/Info

Title:
Advances in Research on the Relationship between Cell Marker Musashi-1 and Endometriosis
文章编号:
1006-1959(2018)23-0048-03
作者:
李跃飞1郑晶晶2于聪祥2
1.内蒙古妇幼保健院妇产科,内蒙古 呼和浩特 010050;2.内蒙古医科大学附属医院妇产科,内蒙古 呼和浩特 010050
Author(s):
LI Yue-fei1ZHENG Jing-jing2YU Cong-xiang2
1.Department of Obstetrics and Gynecology,Inner Mongolia Maternal and Child Health Hospital,Hohhot 010050,Inner Mongolia,China;2.Department of Obstetrics and Gynecology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia,China
关键词:
子宫内膜异位症干细胞Musashi-1
Keywords:
EndometriosisStem cellsMusashi-1
分类号:
R711.71
DOI:
10.3969/j.issn.1006-1959.2018.23.014
文献标志码:
A
摘要:
子宫内膜异位症是雌激素依赖的多因素疾病。干细胞是机体内具有自我更新及多向分化潜能的未分化细胞群,能无限增埴分裂。EMs确切发病机制尚不完全清楚。近年国内外研究发现,子宫内膜干细胞的异常增殖、分化将导致EMs的发生,因此提出EMs可能是一种干细胞疾病。Musashi-1是最新发现的肿瘤干细胞标志物之一,其在Wnt/β-catenin等信号转导通路中发挥着重要作用,与EMs的发生、发展密切相关。现就干细胞标志物Musashi-1与子宫内膜异位症发病关系进行综述。
Abstract:
Endometriosis is a multifactorial disease of estrogen dependence,Stem cells are undifferentiated cells with self-renewal and multiple differentiation potentials within the body. It can multiply and divide indefinitely. The exact pathogenesis of EMs is not fully understood. In recent years, domestic and international studies have found that, abnormal proliferation and differentiation of endometrial stem cells will result in EMs, so it may be a stem cell disease. Musashi-1 is one of the most recently discovered tumor stem cell markers, which plays an important role in the signal transduction pathway of Wnt/β-catenin, which is closely related to the occurrence and development of EMs. The relationship between stem cell marker Musashi-1 and endometriosis is summarized as follows.

参考文献/References:

[1]Fuentes A,Escalona J,Céspedes P,et al.Prevalence of endometriosis in 287 women undergoing surgical sterilization in Santiago Chile[J].Rev Med Chil,2014,142(1):16-19.
[2]郎景和.以转化医学的观点促进子宫内膜异位症的研究[J].国际妇产科学杂志,2011,38(4):261-270.
[3]Dhesi AS,Morelli SS.Endometriosis:a role for stem cells[J].Womens Health(Lond),2015,11(1):35-49.
[4]Hufnagel D,Li F,Cosar E,et al.The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis[J].Semin Reprod Med,2015,33(5):333-340.
[5]张继雯,宋殿荣,张崴,等.人子宫内膜异位症在位子宫内膜干细胞的分离和鉴定[J].国际妇产科学杂志,2017,44(1):113-117.
[6]彭艳,何援利,刘芳,等.骨髓间充质干细胞参与子宫内膜异位症形成的实验研究[J].实用妇产科杂志,2014,26(07):517-518.
[7]Cervelló I,Mirantes C,Santamaria X,et al.Stem cells in human endometrium and endometrial carcinoma[J].Int J Gynecol Pathol,2011,30(4):317-327.
[8]Sutherland JM,Mclaughlin EA,Hime GR,et al.The musashi family of RNA binding proteins:master regulators of multiple stem cell populations[J].Adv Exp Med Biol,2013,786(13):233-245.
[9]苏克举,王旭,何华,等.肿瘤干细胞标志物Musashi1与实体肿瘤关系的研究进展[J].吉林大学学报(医学版),2015,41(2):429-432.
[10]李玲,赵治国,郑鹏远,等.Musashi-1和尾侧型同源转录因子2在肠上皮化生及胃癌组织中的表达及意义[J].广东医学,2015(2):269-272.
[11]Tanaka K,Tomita H,Hisamatsu K,et al.ALDH1A1-overex-pressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma[J].Oncotarget,2015,6(28):24722-24732.
[12]黄江生.胆总管腺癌Musashi-1和ALDH1表达及其临床病理意义[J].中国现代医学杂志,2011,21(35):4409-4413.
[13]Liu DC,Yang ZL,Jiang S.Identification of musashi-1 and ALDH1 as carcinogenesis,progression,and poor-prognosis related biomarkers for gallbladder adenocarcinoma[J].Cancer Biomark,2010,8(3):113-121.
[14]Dandawate PR,Subramaniam D,Jensen RA,et al.Targeting cancer stem cells and signaling pathways by phytochemicals:movel approach for breast cancer therapy[J].Semin Cancer Biol,2016,40(41):192-208.
[15]Wang XY,Penalva LO,Yuan H,et al.Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival[J].Molecular Cancer,2010,9(1):221.
[16]Jang GB,Hong IS,Kim RJ,et al.Wnt/β-Catenin small-molecule inhibitor cwp232228 preferentially inhibits the growth of breast cancer stem-like cells[J].Cancer Res,2015,75(8):1691-1702.
[17]丁文婧,马莉,滕银成,等.Musashi-1在子宫内膜腺癌中的表达及其评估预后的价值[J].上海交通大学学报(医学版),2015,35(7):1028-1033.
[18]Gotte M,Greve B,Kelsch R,et al.The adult stem cell marker Musashi-1 modulates endometrial carcinoma cell cycle progression and apoptosis via Notch-1 and p21 WAF1/CIP[J].International Journal of Cancer,2011,129(8):2042-2049.
[19]Deane JA,Ong YR,Cain JE,et al.The mouse endometrium contains epithelial,endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase[J].Mol Hum Reprod,2016,22(4):272-284.
[20]Yu CX,Song JH,Liang L,Correlation of changes of (non)exfoliated endometrial organelles and expressions of Musashi-1 and β-catenin with endometriosis in menstrual period[J].Gynecol Endocrinol,2014,30(12):861-867.
[21]Ulrich D,Muralitharan R,Gargett CE.Toward the use of endometrial and menstrual blood mesenchymal stem cells for cell-based therapies[J].Expert Opin Biol TH,2013,13(10):1387-1400.
[22]Yu CX,Song JH,Li YF,et al.Correlation between replicative senescence of endometrial gland epithelial cells in shedding and non-shedding endometria and endometriosis cyst during menstruation[J].Gynecol Endocrinol,2018(25):1-6.

相似文献/References:

[1]郭晓钰.子宫内膜异位症性不孕的中西医治疗[J].医学信息,2022,35(09):58.[doi:10.3969/j.issn.1006-1959.2022.09.014]
 GUO Xiao-yu.Chinese and Western Medicine Treatment of Endometriosis Infertility[J].Journal of Medical Information,2022,35(23):58.[doi:10.3969/j.issn.1006-1959.2022.09.014]
[2]刘秀娟,马艳华,马月巧,等.腹腔镜联合罗氏内异方治疗中、重度子宫内膜异位症 相关不孕的疗效观察[J].医学信息,2018,31(13):77.[doi:10.3969/j.issn.1006-1959.2018.13.022]
 LIU Xiu-juan,MA Yan-hua,MA Yue-qiao,et al.Observation on the Curative Effect of Laparoscopic Combined with Luo’s Internal Prescription for Severe Endometriosis Related Infertility[J].Journal of Medical Information,2018,31(23):77.[doi:10.3969/j.issn.1006-1959.2018.13.022]
[3]刘秀娟,刘 辉.子宫内膜异位症相关性不孕的诊断及治疗研究[J].医学信息,2018,31(14):35.[doi:10.3969/j.issn.1006-1959.2018.14.012]
 LIU Xiu-juan,LIU Hui.Diagnosis and Treatment of Endometriosis Related Infertility[J].Journal of Medical Information,2018,31(23):35.[doi:10.3969/j.issn.1006-1959.2018.14.012]
[4]孔俊沣,钟 雯,刘 嵩,等.MRI对卵巢子宫内膜异位囊肿的诊断价值[J].医学信息,2022,35(11):165.[doi:10.3969/j.issn.1006-1959.2022.11.044]
 KONG Jun-feng,ZHONG Wen,LIU Song,et al.The Diagnostic Value of MRI in Ovarian Endometriotic Cyst[J].Journal of Medical Information,2022,35(23):165.[doi:10.3969/j.issn.1006-1959.2022.11.044]
[5]邬素珍,许焕英,陈 玉,等.子宫内膜异位症痛经患者体质分布规律研究[J].医学信息,2019,32(15):80.[doi:10.3969/j.issn.1006-1959.2019.15.025]
 WU Su-zhen,XU Huan-ying,CHEN Yu,et al.Study on the Distribution Law of Dysmenorrhea in Patients with Endometriosis[J].Journal of Medical Information,2019,32(23):80.[doi:10.3969/j.issn.1006-1959.2019.15.025]
[6]陆 辉,王 冰,祁兴顺.干细胞文献汇总分析[J].医学信息,2019,32(24):32.[doi:10.3969/j.issn.1006-1959.2019.24.011]
 LU Hui,WANG Bing,QI Xing-shun.Summary of Stem Cell Literature[J].Journal of Medical Information,2019,32(23):32.[doi:10.3969/j.issn.1006-1959.2019.24.011]
[7]陈 玉,邬素珍,朱巧玲.子宫内膜异位症痛经患者情志状况的临床观察[J].医学信息,2020,33(01):106.[doi:10.3969/j.issn.1006-1959.2020.01.032]
 CHEN Yu,WU Su-zhen,ZHU Qiao-ling.Clinical Observation of Emotional Status in Patients with Endometriosis Dysmenorrhea[J].Journal of Medical Information,2020,33(23):106.[doi:10.3969/j.issn.1006-1959.2020.01.032]
[8]李国馨.妇科因素所致慢性盆腔痛的研究[J].医学信息,2020,33(05):59.[doi:10.3969/j.issn.1006-1959.2020.05.018]
 LI Guo-xin.Study on Chronic Pelvic Pain Caused by Gynecological Factors[J].Journal of Medical Information,2020,33(23):59.[doi:10.3969/j.issn.1006-1959.2020.05.018]
[9]杜 娟.亮丙瑞林治疗子宫内膜异位症伴不孕的应用[J].医学信息,2020,33(13):43.[doi:10.3969/j.issn.1006-1959.2020.13.012]
 DU Juan.Application of Leuprolide in the Treatment of Endometriosis with Infertility[J].Journal of Medical Information,2020,33(23):43.[doi:10.3969/j.issn.1006-1959.2020.13.012]
[10]李昌秀,黄 婷.直肠子宫内膜异位症1例报道[J].医学信息,2020,33(17):191.[doi:10.3969/j.issn.1006-1959.2020.17.060]

更新日期/Last Update: 2018-12-17