[1]曹立杰,杨林瀛,于国云,等.N-末端脑钠肽前体与社区获得性肺炎患者严重程度关系研究[J].医学信息,2018,31(04):1-3.[doi:10.3969/j.issn.1006-1959.2018.04.001]
　CAO Li-jie,YANG Lin-ying,YU Guo-yun,et al.Study on the Relationship between N-terminal Brain Natriuretic Peptide Precursors and the Severity of Community-acquired Pneumonia[J].Medical Information,2018,31(04):1-3.[doi:10.3969/j.issn.1006-1959.2018.04.001]
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N-末端脑钠肽前体与社区获得性肺炎患者严重程度关系研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年04期
页码:
1-3
栏目:
出版日期:
2018-02-15

文章信息/Info

Title:
Study on the Relationship between N-terminal Brain Natriuretic Peptide Precursors and the Severity of Community-acquired Pneumonia
文章编号:
1006-1959（2018）04-0001-03
作者:
曹立杰; 杨林瀛; 于国云; 杜丽艳
承德医学院附属医院呼吸内科，河北 承德 067000
Author(s):
CAO Li-jie; YANG Lin-ying; YU Guo-yun; DU Li-yan
Department of Respiratory Medicine,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China
关键词:
社区获得性肺炎; NT-proBNP; PSI评分
Keywords:
Key words：Community-acquired pneumonia; NT-proBNP; PSI score
分类号:
R563.1
DOI:
10.3969/j.issn.1006-1959.2018.04.001
文献标志码:
A
摘要:
目的 探讨血清N-末端脑钠肽前体浓度与社区获得性肺炎的严重程度的关系。方法 对2016年11月~2017年4月于我院呼吸科住院的46例CAP 患者评估临床变量和肺炎严重指数，按照 PSI评分分组，比较各组血清NT-proBNP浓度，评价其与CAP严重程度关系。结果 NT-proBNP与PSI评分、Spearman相关（r＝0.654，P＜0.05）；NT-proBNP与年龄Spearman相关（r＝0.530，P＜0.05）；NT-proBNP与呼吸频率Spearman相关（r＝0.382，P＜0.05），且各组NT-proBNP浓度随PSI分级升高而升高。NT-proBNP浓度与CAP病情严重程度呈正相关（r＝0.654，P＜0.05）。结论 NT-proBNP与PSI评分呈显著正相关，其可以作为评估CAP患者病情严重程度的有效指标，但本研究样本量较少，结果可能存在一定的局限性，以及NT-proBNP水平与感染病原体是否相关还需进一步研究。
Abstract:
Abstract：Objective To investigate the relationship between the concentration of serum N-terminal brain natriuretic peptide(NTP)and the severity of community-acquired pneumonia(CPAP).Methods The clinical variables and the severity index of pneumonia were evaluated in 46 CAP patients hospitalized in respiratory department from November 2016 to April 2017.According to the PSI score,the serum NT-proBNP concentration was compared.Evaluate its relationship with CAP severity.Results NT-proBNP and PSI were correlated with Spearman score (r=0.654,P<0.05);NT-proBNP was associated with Spearman age(r=0.530,P<0.05).NT-proBNP was correlated with respiratory frequency Spearman（r=0.382，P<0.05）,the concentration of NT-proBNP in each group increased with the increase of PSI grade.The concentration of NT-proBNP was positively correlated with the severity of CAP(r=0.654,P<0.05).Conclusion There is a significant positive correlation between NT-proBNP and PSI score,which can be used as an effective index to evaluate the severity of CAP in patients with CAP.However,the sample size in this study is small,and the results may have some limitations,and whether NT-proBNP levels and pathogen infection related needs further study.

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更新日期/Last Update: 2018-02-15