[1]王 静,郭宏敏.肝型脂肪酸结合蛋白在糖尿病中的研究[J].医学信息,2019,(18):18-20.[doi:10.3969/j.issn.1006-1959.2019.18.007]
 WANG Jing,GUO Hong-min.Study on Hepatic Fatty Acid Binding Protein in Diabetes[J].Medical Information,2019,(18):18-20.[doi:10.3969/j.issn.1006-1959.2019.18.007]
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肝型脂肪酸结合蛋白在糖尿病中的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年18期
页码:
18-20
栏目:
综述
出版日期:
2019-09-15

文章信息/Info

Title:
Study on Hepatic Fatty Acid Binding Protein in Diabetes
文章编号:
1006-1959(2019)18-0018-03
作者:
王 静1郭宏敏2
1.太仓中医医院内分泌科,江苏 太仓 215400; 2.江苏省中医院老年科,江苏 南京 210029
Author(s):
WANG Jing1GUO Hong-min2
1.Department of Endocrinology,Taicang Hospital of Traditional Chinese Medicine,Taicang 215400,Jiangsu,China; 2.Department of Geriatrics,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China
关键词:
肝型脂肪酸结合蛋白糖尿病糖尿病肾病
Keywords:
Key words:Hepatic fatty acid binding proteinDiabetesDiabetic nephropathy
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2019.18.007
文献标志码:
A
摘要:
肝型脂肪酸结合蛋白(L-FABP)在肝脏、肾脏等组织细胞中表达。有研究表明,L-FABP与糖尿病的发生、发展密切相关。同时作为肾损伤的敏感指标,尿L-FABP成为糖尿病肾病早期诊断的标志物之一并能预测病情的转归。本文就肝型脂肪酸结合蛋白在糖尿病中的研究进展进行综述。
Abstract:
Abstract:Hepatic fatty acid binding protein (L-FABP) is expressed in tissue cells such as liver and kidney. Studies have shown that L-FABP is closely related to the occurrence and development of diabetes. At the same time, as a sensitive indicator of kidney injury, urinary L-FABP becomes one of the early markers of diabetic nephropathy and can predict the outcome of the disease. This article reviews the research progress of hepatic fatty acid binding protein in diabetes.

参考文献/References:

[1]Michael DS.Digestion and absorption of dietary triglycerides.In:Leung Po Sing,editor.The gastrointestinal system:gastrointestinal,nutritional and hepatobiliary physiology[M].New York:E-Publishing Inc,2014:160-178. [2]Huang H,Mc Intosh AL,Martin GG,et al.Structural and functional interaction of fatty acids with human liver fatty acid binding protein(L-FABP)T94A variant[J].FEBS J,2014,281(9):2266-2283. [3]Atshaves BP,Martin GG,Hostetler HA,et al.Liver fatty acid binding protein and obesity[J].J Nutr Biochem,2010,21(6):1015-1032. [4]Martin GG,Atshaves BP,McIntosh AL,et al.Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity[J].J Nutr,2008,138(10):1859-1865. [5]Schachtrup C,Emmler T,Bleck B,et al.Functional analysis of peroxisome proliferator responsive element motifs in genes of fatty acid binding proteins[J].Biochem J,2004,382(Pt1):239-245. [6]Chen XY,Li R,Geng ZY.Cold stress initiates the Nrf2/UGT1A1/L-FABP signaling pathway in chickens[J].Poult Sci,2015,94(11):2597-2603. [7]Hyunwoo Kim,Gaae Gil,Siyoung Lee,et al.Cytokine-like Activity of Liver Type Fatty Acid Binding Protein(L-FABP)Inducing Inflammatory Cytokine Interleukin-6[J].Immune Netw,2016,16(5):296-304. [8]Huang H,Mcintosh AL,Martin GG,et al.Inhibitors of Fatty Acid Synthesis Induce PPARα-Regulated Fatty Acid β-Oxidative Genes:Synergistic Roles of L-FABP and Glucose[J].PPAR Research,2013,2013(2013):865604. [9]Ichikawa D,Kamijo-Ikemori A,Sugaya T,et al.Renal liver-type fatty acid binding protein attenuates angiotensin Ⅱ-induced renal injury[J].Hypertension,2012,60(4):973-980. [10]Yang J,Choi HM,Seo MY,et al.Urine liver-type fatty acid-binding protein predicts graft outcome up to 2 years after kidney transplantation[J].Transplant Proc,2014,46(2):376-380. [11]Parr SK,Clark AJ,Bian A,et al.Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury[J].Kidney Int,2015,87(3):640-648. [12]Belcher JM,Garcia-Tsao G,Sanyal AJ,et al.Urinary biomarkers and progression of AKI in patients with cirrhosis[J].Clin J Am Soc Nephrol,2014,9(11):1857-1867. [13]Viswanathan V,Sivakumar S,Sekar V,et al.Clinical significance of urinary liver-type fatty acid binding protein at various stages of nephropathy[J].Indian J Nephrol,2015,25(5):269-273. [14]黄志勇,王利,汪慧,等.糖尿病肾病患者尿L-FABP的检测及其临床意义[J].武汉大学学报,2015,36(2):266-269. [15]Araki SI,Haneda M,Koya D,et al.Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy[J].Diabetes Care,2013,36(5):1248-1253. [16]Abd El Dayem S,El Bohy Ael M,El Shehaby A.Follow up of value of the intrarenal resistivity indices and different renal biomarkers for early identification of diabetic nephropathy in type 1 diabetic patients[J].J Pediatr Endocrinol Metab,2016,29(3):273-279. [17]Fu WJ,Wang DJ,Deng RT,et al.Urinary liver-type fatty acid-binding protein Change in gestational diabetes mellitus[J].Diabetes Res Clin Pract,2015,109(3):e36-e38. [18]Suh JS,Kim SH,Cho KS,et al.Urinary markers in the early stage of nephropathy in patients with childhood-onset type 1 diabetes[J].Pediatr Nephrol,2016,31(4):623-631. [19]Chou KM,Lee CC,Chen CH,et al.Clinical value of NGAL,L-FABP and albuminuria in predicting GFR decline in type 2 diabetes mellitus patients[J].PLoS One,2013,8(1):e54863. [20]Hiroyuki Ito,Hitomi Yamashita,Mina Nakashima,et al.Current metabolic status affects urinary liver-type fatty-acid binding protein in normoalbuminuric patients with type 2 diabetes[J].J Clin Med Res,2017,9(4):366-373. [21]Maeda Y,Suzuki A,Ishii J,et al.Level of urinary liver-type fatty acid-binding protein is associated with cardiac markers and electrocardiographic abnormalities in type-2 diabetes with chronic kidney disease stage G1 and G2[J].Heart Vessels,2014,30(3):362-368. [22]Atsuko Kamijo-Ikemori A,Sugaya T,Sekizuka A,et al.Amelioration of diabetic tubulointerstitial damage in liver-type fatty acid-binding protein transgenic mice[J].Nephrol Dial Transplant,2009,24(3):788-800. [23]Panduru NM,Forsblom C,Saraheimo M.Urinary liver-type fatty acid binding protein is an independent predictor of stroke and mortality in individuals with type 1 Diabetes[J].Diabetologia,2017,60(9):1782-1790. [24]Nakamura T,Fujiwara N,Sato E,et al.Renoprotective Effects of Various Angiotensin Ⅱ Receptor Blockers in Patients with Early-Stage Diabetic Nephropathy[J].Kidney Blood Press Res,2010,33(3):213-220. [25]Abe M,Oikawa O,Okada K,et al.Urinary angiotensin-converting enzyme 2 increases in diabetic nephropathy by angiotensin Ⅱ type 1 receptor blocker olmesartan[J].J Renin Angiotensin Aldosterone Syst,2015,16(1):159-164. [26]Abe M,Maruyama N,Okada K,et al.Additive antioxidative effects of azelnidipine on angiotensin receptor blocker olmesartan treatment for type 2 diabetic patients with albuminuria[J].Hypertens Res,2011,34(8):935-941. [27]Kitada M,Tsuda SI,Konishi K,et al.Anagliptin ameliorates albuminuria and urinary liver-type fatty acid-binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent manner[J].BMJ Open Diabetes Res Care,2017,5(1):e000391. [28]Makino H,Matsuo M,Hishida A,et al.Effect of linagliptin on oxidative stress markers in patients with type 2 diabetes:a pilot study[J].Diabetol Int,2018,10(2):148-152. [29]Wang J,Guo HM.Astragaloside IV ameliorates high glucose-induced HK-2 cell apoptosis and oxidative stress by regulating the Nrf2/ARE signaling pathway[J].Exp Ther Med,2019,17(6):4409-4416. [30]Yang X,Zhang B,Lu X,et al.Effects of Tangshen Formula on urinary and plasma liver-type fatty acid binding protein levels in patients with type 2 diabetic kidney disease:post-hoc findings from a multi-center,randomized,double-blind,placebo-controlled trial investigating the efficacy and safety of Tangshen Formula in patients with type 2 diabetic kidney disease[J].BMC Complementary and Alternative Medicine,2016(16):246.

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更新日期/Last Update: 2019-09-15