[1]陈李平,杨雅清,黄润青,等.我国琥珀酸亚铁片与硫酸亚铁片治疗缺铁性贫血疗效的有效性Meta分析[J].医学信息,2019,32(08):92-96.[doi:10.3969/j.issn.1006-1959.2019.08.027]
　CHEN Li-ping,YANG Ya-qing,HUANG Run-qing,et al.Meta-analysis on the Efficacy of Ferrous Succinate Tablets and Ferrous Sulfate Tablets in the Treatment of Iron Deficiency Anemia[J].Journal of Medical Information,2019,32(08):92-96.[doi:10.3969/j.issn.1006-1959.2019.08.027]
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我国琥珀酸亚铁片与硫酸亚铁片治疗缺铁性贫血疗效的有效性Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年08期
页码:
92-96
栏目:
论著
出版日期:
2019-04-15

文章信息/Info

Title:
Meta-analysis on the Efficacy of Ferrous Succinate Tablets and Ferrous Sulfate Tablets in the Treatment of Iron Deficiency Anemia
文章编号:
1006-1959（2019）08-0092-05
作者:
陈李平1; 杨雅清1; 黄润青1; 李 劲2; 王 丽2; 李 璠1
（1.昆明医科大学药学院暨云南省天然药物药理重点实验室，云南 昆明 650500；2.云南白药集团股份有限公司，云南 昆明 650500）
Author(s):
CHEN Li-ping1; YANG Ya-qing1; HUANG Run-qing1; LI Jin2; WANG Li2; LI Fan1
(1.College of Pharmacy,Kunming Medical University and Yunnan Key Laboratory of Pharmacology of Natural Medicines,Kunming 650500,Yunnan,China;2.Yunnan Baiyao Group Co.,Ltd.,Kunming 650500,Yunnan,China)
关键词:
缺铁性贫血; 硫酸亚铁片; 琥珀酸亚铁片; 有效性; Meta分析
Keywords:
Iron deficiency anemia; Ferrous sulfate tablets; Ferrous succinate tablets;  Effectiveness; Meta-analysis
分类号:
R714.254
DOI:
10.3969/j.issn.1006-1959.2019.08.027
文献标志码:
A
摘要:
目的 评价硫酸亚铁片与琥珀酸亚铁片治疗缺铁性贫血的临床有效性。方法 利用计算机对文献进行检索，所用数据库包括中国期刊全文数据库（CNKI）、万方数据库（Wan Fang Data）和维普数据库（VIP），英文数据库Pubmed和Embase。纳入硫酸亚铁片与琥珀酸亚铁片治疗缺铁性贫血的随机对照试验文献，数据由两名评价员进行分别独立提取纳入文献，并对文献质量进行评价，使用RevMan5.0软件对纳入文献进行统计分析，评价二者临床有效性。结果 纳入研究有15篇文献，文章无明显发表偏倚；从随即对照文献的质量评价结果可知，Meta分析稳定、可靠；琥珀酸亚铁组的有效率高于硫酸亚铁组（RR：1.22,95% CI：1.13～1.32：P＜0.00001）。结论 综合分析两种药物治疗缺铁性贫血的临床有效性，表明琥珀酸亚铁片在治疗缺铁性贫血方面较硫酸亚铁片更有效；但在未来研究中应克服相应的方法学缺陷。
Abstract:
Objective To evaluate the clinical efficacy of ferrous sulfate tablets and ferrous succinate tablets in the treatment of iron deficiency anemia. Methods The literature was searched by computer. The databases used included China Journal Full-text Database (CNKI), Wanfang Data and VIP Database (VIP), and English databases Pubmed and Embase. A randomized controlled trial of ferrous sulfate tablets and ferrous succinate tablets for the treatment of iron deficiency anemia was performed. The data were independently extracted by two reviewers and included in the literature. The quality of the literature was evaluated and included in the literature using RevMan 5.0 software. Statistical analysis was performed to evaluate the clinical effectiveness of the two. Results There were 15 articles in the study, and there was no significant publication bias. The results of the quality evaluation of the randomized controlled literature showed that the meta-analysis was stable and reliable; the ferrous succinate group was more efficient than the ferrous sulfate group (RR: 1.22, 95). % CI: 1.13 to 1.32: P<0.00001). Conclusion The clinical efficacy of two drugs in the treatment of iron deficiency anemia is comprehensively analyzed, indicating that ferrous succinate tablets are more effective in treating iron deficiency anemia than ferrous sulfate tablets; however, the corresponding methodological defects should be overcome in future research.

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更新日期/Last Update: 2019-04-15