[1]何大海.平均红细胞血红蛋白含量对糖化血红蛋白结果的影响研究[J].医学信息,2019,32(09):85-87.[doi:10.3969/j.issn.1006-1959.2019.09.027]
　HE Da-hai.Effect of Mean Red Blood Cell Hemoglobin Content on Glycosylated Hemoglobin[J].Journal of Medical Information,2019,32(09):85-87.[doi:10.3969/j.issn.1006-1959.2019.09.027]
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平均红细胞血红蛋白含量对糖化血红蛋白结果的影响研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年09期
页码:
85-87
栏目:
论著
出版日期:
2019-05-01

文章信息/Info

Title:
Effect of Mean Red Blood Cell Hemoglobin Content on Glycosylated Hemoglobin
文章编号:
1006-1959（2019）09-0085-03
作者:
何大海
（成都市郫都区中医医院检验科，四川 成都 611730）
Author(s):
HE Da-hai
(Department of Clinical Laboratory,Chengdu Pidu District Chinese Medicine Hospital,Chengdu 611730,Sichuan,China)
关键词:
糖化血红蛋白; 糖尿病; 红细胞参数; 贫血
Keywords:
Glycated hemoglobin; Diabetes; Red blood cell parameters; Anemia
分类号:
R446.11
DOI:
10.3969/j.issn.1006-1959.2019.09.027
文献标志码:
A
摘要:
目的 探讨平均红细胞血红蛋白含量（MCH）和红细胞平均体积（MCV）对糖化血红蛋白（HbA1c）影响情况。方法 本研究共纳入表观正常人群3369例，按照不同的HbA1c值分为三个组：A组：HbA1c≥6.5%（88例）、B组：6.5%＞HbA1c＞5.7%（615例）和C组：HbA1c≤5.7%（2666例）。按不同MCH分为：MCH≤26 pg的低值组120例、26 pg＜MCH＜34 pg的中值组3479例和MCH≥34 pg的高值组27例。采用偏相关分析红细胞参数对HbA1c检测结果的影响。进一步以HbA1c作为因变量，采用多元线性回归分析HbA1c的预测变量。结果 三组患者年龄、HbA1c、FPG、RBC、MCV、MCH和HCT值比较，差异均有统计学意义（P＜0.05）；A组MCV水平最高，其次是B组，C组MCV水平最低，三组间比较差异有统计学意义（P＜0.05）； MCH、MCV与HbA1c呈负相关（r=-0.217、-0.187， P＜0.001）；RBC与HbA1c呈正相关（r=0.161，P＜0.05）。通过逐步回归分析得出，FPG、RBC、性别、MCH和年龄可预测HbA1c值（r2=0.40，P＜0.05）。HbA1c随随MCH和MCV的增加而降低，随FPG、年龄和RBC的增加而升高。结论 当出现血糖水平与HbA1c值不一致时，可能是因为HbA1c受多种因素影响而不能反映真实血糖水平。
Abstract:
Objective To investigate the effect of mean red blood cell hemoglobin content (MCH) and mean red blood cell volume (MCV) on glycosylated hemoglobin (HbA1c). Methods A total of 3369 patients in the apparent normal population were included in the study. They were divided into three groups according to different HbA1c values: group A: HbA1c≥6.5% (88 cases), group B: 6.5%>HbA1c>5.7% (615 cases) and C Group: HbA1c ≤ 5.7% (2666 cases). According to different MCH, there were 120 cases in the low value group with MCH≤26 pg, 3479 cases in the median group with 26pg

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更新日期/Last Update: 2019-05-01