[1]贾 丁,王春红,杨孝燕,等.程序性死亡因子1及其配体在脑胶质瘤中的研究进展[J].医学信息,2019,32(10):47-49.[doi:10.3969/j.issn.1006-1959.2019.10.017]
 JIA Ding,WANG Chun-hong,YANG Xiao-yan,et al.Progress in the Study of Programmed Death Factor 1 and its Ligands in Glioma[J].Journal of Medical Information,2019,32(10):47-49.[doi:10.3969/j.issn.1006-1959.2019.10.017]
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程序性死亡因子1及其配体在脑胶质瘤中的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年10期
页码:
47-49
栏目:
综述
出版日期:
2019-05-15

文章信息/Info

Title:
Progress in the Study of Programmed Death Factor 1 and its Ligands in Glioma
文章编号:
1006-1959(2019)10-0047-03
作者:
贾 丁王春红杨孝燕李 强吉宏明
(山西医科大学附属人民医院神经外科,山西 太原 030012)
Author(s):
JIA DingWANG Chun-hongYANG Xiao-yanLI QiangJI Hong-ming
(Department of Neurosurgery,People's Hospital Affiliated to Shanxi Medical University,Taiyuan 030012,Shanxi,China)
关键词:
脑胶质瘤程序性死亡因子1肿瘤免疫治疗
Keywords:
GliomaProgrammed death factor 1Tumor immunotherapy
分类号:
R739.41
DOI:
10.3969/j.issn.1006-1959.2019.10.017
文献标志码:
A
摘要:
脑胶质瘤一直是中枢神经系统肿瘤研究的重点及难点,高级别胶质瘤因其浸润生长快,位置特殊,综合治疗后效果并不理想。肿瘤免疫治疗通过维持肿瘤与免疫系统的平衡,恢复机体抗肿瘤免疫应答,从而限制肿瘤的发生、发展。目前免疫治疗已运用与多种实体瘤中,并取得了令人欣喜的结果,也为脑胶质瘤的治疗提供了新的思路。阻断PD-1/PD-L1是目前肿瘤免疫治疗的热点。本文就PD-1/PD-L1在脑胶质瘤中的研究及治疗进展进行综述。
Abstract:
Gliomas have always been the focus and difficulty of central nervous system tumor research. High-grade gliomas are not ideal because of their invasive growth and special location. Tumor immunotherapy restores the body's anti-tumor immune response by maintaining the balance between the tumor and the immune system, thereby limiting the occurrence and development of the tumor. At present, immunotherapy has been applied to a variety of solid tumors, and has achieved gratifying results, and also provides new ideas for the treatment of glioma. Blocking PD-1/PD-L1 is currently a hot spot in tumor immunotherapy. This article reviews the research and treatment progress of PD-1/PD-L1 in glioma.

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更新日期/Last Update: 2019-05-15