[1]林思萍,龚先琼.中药单体调控TGF-β1/Smads信号通路抗纤维化的研究[J].医学信息,2019,32(21):30.[doi:10.3969/j.issn.1006-1959.2019.21.011]
　LIN Si-ping,GONG Xian-qiong.Study on Anti-Fibrosis of TGF-β1/Smads Signaling Pathway Regulated by Chinese Medicine Monomer[J].Journal of Medical Information,2019,32(21):30.[doi:10.3969/j.issn.1006-1959.2019.21.011]
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中药单体调控TGF-β1/Smads信号通路抗纤维化的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年21期
页码:
30
栏目:
综述
出版日期:
2019-11-01

文章信息/Info

Title:
Study on Anti-Fibrosis of TGF-β1/Smads Signaling Pathway Regulated by Chinese Medicine Monomer
文章编号:
1006-1959（2019）21-0030-04
作者:
林思萍1; 龚先琼2
（1.福建中医药大学，福建 福州 351012；2.福建中医药大学附属厦门中医院，福建 厦门 361009）
Author(s):
LIN Si-ping1; GONG Xian-qiong2
(1.Fujian University of Traditional Chinese Medicine,Fuzhou 351012,Fujian,China;2.Xiamen Traditional Chinese Medicine Hospital,Fujian University of Traditional Chinese Medicine,Xiamen 361009,Fujian,China)
关键词:
中药单体; TGF-β1/Smads信号通路; 肝纤维化
Keywords:
Traditional Chinese medicine monomer; TGF-β1/Smads signaling pathway; Liver fibrosis
分类号:
R284.1
DOI:
10.3969/j.issn.1006-1959.2019.21.011
文献标志码:
A
摘要:
肝纤维化是多种慢性肝病的共同结局，是肝硬化的必经阶段。因此，抗纤维化治疗十分迫切，当前缺乏有效的抗纤维化治疗。中药单体可通过多种途径、多个靶点干预肝纤维化的进展。转化生长因子β1（TGF-β1）/Smads 信号通路在肝纤维化的发生发展中扮演着至关重要的角色。本文就中药单体调控TGF-β1/Smads信号通路抗纤维化的研究作一综述。
Abstract:
Liver fibrosis is the common outcome of many chronic liver diseases and is an inevitable stage of cirrhosis. Therefore, anti-fibrotic treatment is very urgent, and there is currently no effective anti-fibrotic treatment. Traditional Chinese medicine monomers can interfere with the progression of liver fibrosis through multiple pathways and multiple targets. The transforming growth factor β1(TGF-β1)/Smads signaling pathway plays a crucial role in the development of liver fibrosis. This article reviews the research on the anti-fibrosis of TGF-β1/Smads signaling pathway regulated by Chinese medicine monomer.

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更新日期/Last Update: 2019-11-01