[1]潘建鑫.高血压患者血小板/淋巴细胞比值与颈动脉粥样硬化的相关性分析[J].医学信息,2020,33(05):77-79.[doi:10.3969/j.issn.1006-1959.2020.05.023]
　Pan Jianxin.Correlation analysis of platelet/lymphocyte ratio and carotid atherosclerosisin patients with primary hypertension[J].Medical Information,2020,33(05):77-79.[doi:10.3969/j.issn.1006-1959.2020.05.023]
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高血压患者血小板/淋巴细胞比值与颈动脉粥样硬化的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年05期
页码:
77-79
栏目:
论著
出版日期:
2020-03-01

文章信息/Info

Title:
Correlation analysis of platelet/lymphocyte ratio and carotid atherosclerosisin patients with primary hypertension
文章编号:
1006-1959（2020）05-0077-04
作者:
潘建鑫
（重庆医科大学附属大学城医院心血管内科，重庆 401331）
Author(s):
Pan Jianxin
(Department of Cardiology, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China)
关键词:
原发性高血压; 颈动脉粥样硬化; 血小板/淋巴细胞比值
Keywords:
Primary hypertension; Carotid atherosclerosis; Platelet/lymphocyte Ratio
分类号:
R544.1；R543.4
DOI:
10.3969/j.issn.1006-1959.2020.05.023
文献标志码:
A
摘要:
目的 探究原发性高血压（PH）患者的血小板/淋巴细胞比值（PLR）与颈动脉粥样硬化（CAS）的相关性。方法 回顾性分析2018年1月~12月我院收治的PH患者274例，记录患者的性别、年龄、入院时的收缩压（SBP）和舒张压（DBP）、血小板计数（PLT）、淋巴细胞绝对值（L）、血小板/淋巴细胞比值（PLR）及双侧颈部血管彩超等资料。根据是否合并CAS分为CAS组和无CAS组，比较两组一般资料、SBP、DBP、PLT、L及PLR水平；Spearman相关性分析PH合并CAS的影响因素，多因素Logistic回归分析PH合并CAS的独立危险因素，ROC曲线评估PLR对PH合并CAS的预测价值。结果 ①无CAS组患者142例，CAS组患者132例，两组性别、DBP、PLT及L比较，差异无统计学意义（P＞0.05）；但CAS组年龄、SBP、PLR均高于无CAS组，差异有统计学意义（P＜0.05）。②Spearman相关性分析显示，年龄、SBP、PLR与CAS呈正相关（r=0.411、0.410、0.563，P均＜0.05），淋巴细胞绝对值与CAS呈负相关（r=-0.126，P＜0.05）。③多因素Logistic回归分析显示，PLR是PH发生CAS的独立危险因素（OR=1.132，95%CI：1.091~1.175，P=0.000）。④ROC曲线分析显示，PLR预测PH患者出现CAS的曲线下面积（AUC）为0.825，95%CI：0.767~0.883。PLR的最佳截点为128.03，当PLR＞128.03时，PLR 预测PH患者出现CAS的敏感性和特异性分别为74.20%和 92.30%。结论 PLR与PH合并CAS具有一定的相关性，是PH合并CAS的独立预测危险因素，PLR值越大，CAS的发生风险越高。
Abstract:
Objective To study the correlation between platelet/lymphocyte ratio (PLR) and carotid atherosclerosis(CAS) in patients with primary hypertension(PH).Methods We collected the clinical datas of 274 patients with primary hypertension in our hospital from January 2018 to December 2018 and analyzed retrospectively,including gender, age, systolic blood pressure (SBP) ,diastolic blood pressure (DBP), platelet count (PLT), lymphocyte count (L), platelet/lymphocyte ratio(PLR) and bilateral carotid artery ultrasound.According to the results of carotid artery ultrasound,the patients were divided into CAS group and non-CAS group for comparative analysis. The influencing factors of PH combined CAS were analyzed by Spearman correlation. Multivariate Logistic regression analysis was used to study whether PLR was an independent risk factor for PH combined CAS. The predictive value of PLR level for PH combined CAS was evaluated by ROC curve.Results There were 132 patients in the CAS group and 142 patients in the non-CAS group. ①The age, SBP, and PLR in the CAS group were significantly higher than those in the non-CAS group (P<0.05).There was no significant difference in the sex ratio, DBP, platelet count, and lymphocyte count between the two groups (P> 0.05). ②Correlation analysis showed thatage, SBP, and PLR were positively correlated with CAS (r=0.411,0.410,0.563,P<0.05), and lymphocyte countwas negatively correlated with CAS (r=-0.126,P=0.037). ③Multivariate Logistic regression analysis showed that PLR (OR=1.132, 95% CI 1.091~1.175, P=0.000) was an independent risk factor for CAS in PH. ④ ROC curve analysis showed that the area under the curve (AUC) was 0.825 (P<0.05), 95% CI was 0.767~0.883, the optimal cut-off point of PLR was 128.03,and the sensitivity and specificity were74.20% and 92.30%.Conclusions There was a correlation between PLR and PH combined CAS.PLR was an independent predictive risk factor for CAS in PH.

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更新日期/Last Update: 2020-03-01