[1]刘 青,王成银,翁旭亮.化痰通络汤对风痰阻络型急性脑梗死的脑保护作用[J].医学信息,2020,33(15):154-157.[doi:10.3969/j.issn.1006-1959.2020.15.049]
　LIU Qing,WANG Cheng-yin,WENG Xu-liang.Cerebral Protective Effect of Huatan Tongluo Decoction on Acute Cerebral Infarctionof Wind-phlegm Blocking Collaterals[J].Medical Information,2020,33(15):154-157.[doi:10.3969/j.issn.1006-1959.2020.15.049]
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化痰通络汤对风痰阻络型急性脑梗死的脑保护作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年15期
页码:
154-157
栏目:
中医中药
出版日期:
2020-08-01

文章信息/Info

Title:
Cerebral Protective Effect of Huatan Tongluo Decoction on Acute Cerebral Infarctionof Wind-phlegm Blocking Collaterals
文章编号:
1006-1959（2020）15-0154-04
作者:
刘 青; 王成银; 翁旭亮
广州医科大学附属中医医院脑病科，广东 广州 510130
Author(s):
LIU Qing; WANG Cheng-yin; WENG Xu-liang
Department of Brain Disease,the Affiliated Hospital of Traditional Chinese Medicine,Guangzhou Medical University,Guangzhou 510130,Guangdong,Chin
关键词:
化痰通络汤; 急性期脑梗死; 中医证候
Keywords:
Huatan Tongluo Decoction; Acute cerebral infarction; TCM syndrome
分类号:
R459.5
DOI:
10.3969/j.issn.1006-1959.2020.15.049
文献标志码:
A
摘要:
目的 研究化痰通络汤对风痰阻络型急性脑梗死的脑保护作用，为临床提供诊疗思路。方法 选取2016年4月~2019年3月我院脑病科收治的急性脑梗死住院患者72例作为研究对象，按照随机数字表法分为治疗组及对照组，各36例。对照组给予常规治疗，治疗组在对照组治疗基础上加用化痰通络汤，比较两组中医证候疗效、神经功能缺损评分（NIHSS）、日常生活活动能力评分（Barthel指数评分），血栓素B2（TXB2）、6-酮-前列腺素F1α（6-K-PGF1α）浓度。结果 治疗组中医证候总有效率为83.33%，高于对照组的22.22%，差异有统计学意义（P＜0.05）；治疗后，治疗组NIHSS评分、Barthel指数评分、TXB2浓度低于对照组[30.76（3.00，6.00，8.00）分vs 42.24（3.25，8.50，12.00）分]、[50.71（80.00，85.00，95.00）分vs 20.87（60.00，65.00，70.00）分]、[28.58（215.00，248.50，331.50）ng/L vs 44.42（273.75，341.50，387.50）ng/L]，差异有统计学意义（P＜0.05）；治疗组6-K-PGF1α浓度高于对照组[47.32（62.25，67.00，86.50）ng/L vs 25.68（32.25，41.00，52.50）ng/L]，差异有统计学意义（P＜0.05）。结论 化痰通络汤治疗风痰阻络型脑梗死疗效确切，可改善患者神经功能缺损程度与日常生活活动能力，其作用机制可能是通过TXB2/6-K-PGF1α途径改善脑组织血液循环、抗血小板聚集，起到保护脑组织的作用。
Abstract:
Objective To study the protective effect of Huatan Tongluo Decoction on acute cerebral infarction of wind-phlegm blocking collaterals, and provide clinical diagnosis and treatment ideas.Methods A total of 72 inpatients with acute cerebral infarction admitted to our hospital’s encephalopathy department from April 2016 to March 2019 were selected as the research objects. According to the random number table, they were divided into treatment group and control group, with 36 cases in each group. The control group was given conventional treatment, and the treatment group was added with Huatan Tongluo Decoction on the basis of the treatment of the control group to compare the efficacy of TCM syndromes, neurological deficit score (NIHSS), activity of daily living score (Barthel index score), and thrombus The concentration of B2 (TXB2) and 6-keto-prostaglandin F1α (6-K-PGF1α).Results The total effective rate in the treatment of TCM syndrome group was 83.33%, which was higher than 22.22% in the control group,the difference was statistically significant (P<0.05). After treatment, the NIHSS score, Barthel index score and TXB2 concentration of the treatment group was lower than the control group[30.76(3.00，6.00，8.00)point vs 42.24(3.25，8.50，12.00)point]、[50.71(80.00，85.00，95.00)point vs 20.87(60.00，65.00，70.00)point]、[28.58(215.00，248.50，331.50)ng/L vs 44.42(273.75，341.50，387.50)ng/L], the difference was statistically significant (P<0.05); the concentration of 6-K-PGF1α of the treatment group was higher than the control group[47.32(62.25，67.00，86.50)ng/L vs 25.68(32.25，41.00，52.50)ng/L], the difference was statistically significant (P<0.05).Conclusion Huatan Tongluo Decoction has a definite curative effect in the treatment of cerebral infarction of wind-phlegm blocking collaterals, which can improve the neurological deficit and activities of daily living in patients. The mechanism of action may be to improve the blood circulation of brain tissue through TXB2/6-K-PGF1α pathway. Anti-platelet aggregation, play a role in protecting brain tissue.

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更新日期/Last Update: 1900-01-01