[1]戴志鹏.止痛通痹液治疗腰椎间盘突出症的效果及对患者血清炎症因子、PGE2水平的影响[J].医学信息,2020,33(24):154-156.[doi:10.3969/j.issn.1006-1959.2020.24.044]
　DAI Zhi-peng.Effect of Zhitongtongbi Liquid in the Treatment of Prolapse of Lumbar Intervertebral Disc and Its Effect on the Levels of Serum Inflammatory Factors and PGE2 in Patients[J].Medical Information,2020,33(24):154-156.[doi:10.3969/j.issn.1006-1959.2020.24.044]
点击复制

止痛通痹液治疗腰椎间盘突出症的效果及对患者血清炎症因子、PGE2水平的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年24期
页码:
154-156
栏目:
中医中药
出版日期:
2020-12-15

文章信息/Info

Title:
Effect of Zhitongtongbi Liquid in the Treatment of Prolapse of Lumbar Intervertebral Disc and Its Effect on the Levels of Serum Inflammatory Factors and PGE2 in Patients
文章编号:
1006-1959（2020）24-0154-03
作者:
戴志鹏
金溪县人民医院药剂科，江西 金溪 344800
Author(s):
DAI Zhi-peng
Department of Pharmacy,Jinxi County People’s Hospital,Jinxi 344800,Jiangxi,China
关键词:
止痛通痹液; 腰椎间盘突出症; 炎症因子; PGE2
Keywords:
Zhitongtongbi liquid; Prolapse of lumbar intervertebral disc; Inflammatory factor; PGE2
分类号:
R274.9
DOI:
10.3969/j.issn.1006-1959.2020.24.044
文献标志码:
A
摘要:
目的 观察止痛通痹液治疗腰椎间盘突出症的临床效果及对患者血清炎症指标和PGE2水平的影响。方法 选取2017年6月~2020年6月在我院接受治疗的60例腰椎间盘突出症患者为研究对象，采用随机数字表法分为对照组和观察组，各30例。对照组采用常规治疗，观察组在对照组基础上加用止痛通痹液治疗，比较两组临床治疗效果、VAS评分、JOA评分、ODI评分、血清炎症指标、PGE2水平及不良反应发生情况。结果 观察组治疗总有效率为96.67%，高于对照组的83.33%，差异有统计学意义（P＜0.05）；治疗后两组VAS评分、ODI评分均低于治疗前，JOA评分高于治疗前，且观察组VAS评分、ODI评分均低于对照组，JOA评分高于对照组，差异有统计学意义（P＜0.05）；治疗后两组TNF-α、IL-1β、IL-6、PGE2水平均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 止痛通痹液治疗腰椎间盘突出症效果确切，可提高治疗效果，有效改善患者疼痛，提高腰椎功能，促进腰椎恢复，降低炎症因子和PGE2水平，不良反应少，安全性良好，值得临床应用。
Abstract:
Objective To observe the clinical effect of Zhitongtongbi Liquid in treating prolapse of lumbar intervertebral disc and its influence on patients’ serum inflammatory indexes and PGE2 levels.Methods A total of 60 patients with prolapse of lumbar intervertebral disc who were treated in our hospital from June 2017 to June 2020 were selected as the research objects. They were divided into the control group and the observation group by random number table method, with 30 cases in each group. The control group was treated with conventional treatment, and the observation group was treated with Zhitongtongbi Liquid on the basis of the control group. The clinical treatment effect, VAS score, JOA score, ODI score, serum inflammation index, PGE2 level and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%, which was higher than 83.33% in the control group,the difference was statistically significant (P＜0.05); after treatment, the VAS score and ODI score of the two groups were lower than before treatment, and the JOA score was higher than before treatment,the VAS score and ODI score of the observation group were lower than those of the control group, and the JOA score was higher than that of the control group, the difference was statistically significant (P＜0.05); after treatment, the two groups of TNF-α, IL-1β, IL-6, PGE2 The level was lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05); the difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05).Conclusion Zhitongtongbi Liquid is effective in treating prolapse of lumbar intervertebral disc. It can improve the treatment effect, effectively improve the patient’s pain, improve the lumbar function, promote the recovery of the lumbar spine, reduce the level of inflammatory factors and PGE2, with few adverse reactions, good safety, and it is worthy of clinical application.

参考文献/References:

[1]周谋望,岳寿伟,何成奇,等.“腰椎间盘突出症的康复治疗”中国专家共识[J].中国康复医学杂志,2017,32(2):129-135． [2]许敬人,詹红生.腰椎间盘突出症中西康复技术的临床研究进展[J].医学综述,2016,22(14):2809-2814． [3]王翠芳,杨建云,肖炳坤,等.复方中药金铃子散及其单味药镇痛抗炎作用的比较[J].科学技术与工程,2018,18(24):210-212． [4]徐志国,侯勇,张沿洲.老年腰椎间盘突出症患者椎间盘细胞因子水平改变及临床意义[J].中国老年学杂志,2016,36(18):4530-4531． [5]王钦奋,周仕国,刘国铭,等.腰椎间盘突出炎性因子与神经根性疼痛相关性研究[J].医学信息,2018,31(15):59-63． [6]陈柏书,尹建平,朱美玲,等.温针灸治疗腰椎间盘突出症系统评价[J].中国中医药信息杂志,2018,25(2):104-109． [7]朱咏梅,张田宁,田千慧,等.中医药治疗腰椎间盘突出症的临床进展[J].中国中医急症,2018,27(1):175-176,185． [8]Hubbe U,Franco-Jimenez P,Klingler JH,et al.Minimally inva- sive tubular microdiscectomy for recurrent lumbar disc herniation[J].J Neurosurg Spine,2016,24(1):48-53． [9]曹丽萍.观察中药熏蒸加牵引配合独活寄生汤治疗腰椎间盘突出症的临床疗效[J].中医临床研究,2015,5(5):22-23. [10]何飞军.老年肾虚型腰椎间盘突出患者应用针灸推拿的效 果观察及对患者 VAS评分的影响[J].中国急救医学, 2017,37(z1):174-175． [11]陈愉,刘绍凡,徐敏敏,等.独活寄生汤联合塞来昔布胶囊治 疗老年寒湿型腰椎间盘突出的疗效[J].中国老年学杂志,2017,37(10):2508-2510． [12]林锦霞.抗炎镇痛中药马钱子外用制剂的研究进展[J].医学综述,2018,24(16):3259-3263． [13]侯桂红,李倩,谢燕,等.椎间盘组织中炎症因子水平、MMPs/ TIMPs表达与腰椎间盘突出症的关系研究[J].中国实验诊断学,2018,22(5):791-794． [14]赵犹太,朱先龙,李伟,等.中医骨伤手法结合独活寄生汤加减治疗腰椎间盘突出症疗效观察[J].现代中西医结合杂志,2017,26(1):57-59． [15]胡殿磊,胡元春,胡弼尧,等.腰椎间盘突出中医治法新论[J].世界中西医结合杂志,2018,13(6):871-874.

相似文献/References:

[1]王钦奋,周仕国,刘国铭,等.腰椎间盘突出炎性因子与神经根性疼痛相关性研究[J].医学信息,2018,31(15):59.[doi:10.3969/j.issn.1006-1959.2018.15.019]
　WANG Qin-fen,ZHOU Shi-guo,LIU Guo-ming,et al.Correlation between Inflammatory Factors and Nerve Root Pain in Protrusion of Lumbar Intervertebral Disc[J].Medical Information,2018,31(24):59.[doi:10.3969/j.issn.1006-1959.2018.15.019]
[2]丁永国,李昌隆,孙建民,等.经皮穿刺椎间孔镜下应用TESSYS技术治疗 腰椎间盘突出症的临床疗效观察[J].医学信息,2018,31(16):38.[doi:10.3969/j.issn.1006-1959.2018.16.011]
　DING Yong-guo,LI Chang-long,SUN Jian-min,et al.Clinical Observation of Percutaneous Lumbar Disc Herniation Treated by TESSYS Technique under Transforaminal Endoscopy[J].Medical Information,2018,31(24):38.[doi:10.3969/j.issn.1006-1959.2018.16.011]
[3]刘国铭,林世水,周仕国.经皮椎间孔镜和椎板开窗减压术治疗 腰椎间盘突出症的临床疗效对比[J].医学信息,2018,31(17):66.[doi:10.3969/j.issn.1006-1959.2018.17.020]
　LIU Guo-ming,LIN Shi-shui,ZHOU Shi-guo.Comparison of Clinical Outcomes between Percutaneous Transforaminal Decompression and Decompression of Vertebral Lamina Fenestration in the Treatment of Lumbar Disc Herniation[J].Medical Information,2018,31(24):66.[doi:10.3969/j.issn.1006-1959.2018.17.020]
[4]程景山.经皮椎间孔镜技术在腰椎病变中的应用[J].医学信息,2022,35(12):81.[doi:10.3969/j.issn.1006-1959.2022.12.019]
　CHENG Jing-shan.Application of Transforaminal Endoscopic Spine System technique in Lumbar Lesions[J].Medical Information,2022,35(24):81.[doi:10.3969/j.issn.1006-1959.2022.12.019]
[5]张占录.腰椎间盘突出合并相应节段椎管狭窄症的微创手术治疗研究[J].医学信息,2019,32(04):174.[doi:10.3969/j.issn.1006-1959.2019.04.058]
　ZHANG Zhan-lu.Minimally Invasive Surgery for Lumbar Disc Herniation with Corresponding Segmental Spinal Stenosis[J].Medical Information,2019,32(24):174.[doi:10.3969/j.issn.1006-1959.2019.04.058]
[6]王永康,周 政,兑振华,等.针刀联合推拿治疗腰椎间盘突出症随机对照试验的Meta分析[J].医学信息,2022,35(15):99.[doi:10.3969/j.issn.1006-1959.2022.15.022]
　WANG Yong-kang,ZHOU Zheng,DUI Zhen-hua,et al.Meta-analysis of Randomized Controlled Trials of Needle Knife Combined with Massage in the Treatment of Lumbar Disc Herniation[J].Medical Information,2022,35(24):99.[doi:10.3969/j.issn.1006-1959.2022.15.022]
[7]陈华荣,温桃芳,何朝洪,等.椎间孔镜下椎间盘髓核摘除治疗腰椎间盘突出症的疗效[J].医学信息,2019,32(23):112.[doi:10.3969/j.issn.1006-1959.2019.00.031]
　CHEN Hua-rong,WEN Tao-fang,HE Chao-hong,et al.Effect of Intervertebral Disc Nucleus Pulposus Removal on Lumbar Disc Herniation[J].Medical Information,2019,32(24):112.[doi:10.3969/j.issn.1006-1959.2019.00.031]
[8]王 斐.小针刀联合推拿按摩治疗腰椎间盘突出症的效果[J].医学信息,2020,33(03):151.[doi:10.3969/j.issn.1006-1959.2020.03.049]
　WANG Fei.Effect of Small Needle Knife Combined with Massage on Lumbar Disc Herniation[J].Medical Information,2020,33(24):151.[doi:10.3969/j.issn.1006-1959.2020.03.049]
[9]黄建辉.益肾镇痛汤联合小针刀、电脑中频治疗对腰椎间盘突出症患者疼痛及腰椎功能恢复的疗效观察[J].医学信息,2022,35(17):144.[doi:10.3969/j.issn.1006-1959.2022.17.040]
　HUANG Jian-hui.Effect of Yishen Zhentong Decoction Combined with Small Needle Knife and Computer Intermediate Frequency Therapy on Pain and Lumbar Function Recovery in Patients with Lumbar Disc Herniation[J].Medical Information,2022,35(24):144.[doi:10.3969/j.issn.1006-1959.2022.17.040]
[10]赵名娟,张金涛,徐玉振.误诊为脊髓压迫症的脊肌萎缩症1例[J].医学信息,2020,33(12):182.[doi:10.3969/j.issn.1006-1959.2020.12.061]

更新日期/Last Update: 1900-01-01