[1]彭 越,高 宇,王云飞,等.VEGF在糖尿病视网膜病变发病机制中的作用[J].医学信息,2021,34(05):36-39.[doi:10.3969/j.issn.1006-1959.2021.05.011]
 PENG Yue,GAO Yu,WANG Yun-fei,et al.The Role of VEGF in the Pathogenesis of Diabetic Retinopathy[J].Medical Information,2021,34(05):36-39.[doi:10.3969/j.issn.1006-1959.2021.05.011]
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VEGF在糖尿病视网膜病变发病机制中的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年05期
页码:
36-39
栏目:
综述
出版日期:
2021-03-01

文章信息/Info

Title:
The Role of VEGF in the Pathogenesis of Diabetic Retinopathy
文章编号:
1006-1959(2021)05-0036-04
作者:
彭 越高 宇王云飞
(1.滨州医学院药学院,山东 烟台 264000; 2.荣成市东山街道中心卫生院,山东 荣成 264300; 3.荣成市中医院脑病科,山东 荣成 264300)
Author(s):
PENG YueGAO YuWANG Yun-feiet al.
(1.School of Pharmacy,Binzhou Medical University,Yantai 264000,Shandong,China; 2.Central Hospital of Dongshan Street,Rongcheng 264300,Shandong,China; 3.Department of Brain Disease,Rongcheng Hospital of Traditional Chinese Medicine,Rongcheng 264300,Shandon
关键词:
糖尿病视网膜病变视网膜微血管血管内皮生长因子
Keywords:
Diabetic retinopathy Retinal microvascular Vascular endothelial growth factor
分类号:
R774.1;R363.2
DOI:
10.3969/j.issn.1006-1959.2021.05.011
文献标志码:
A
摘要:
糖尿病视网膜病变(DR)是糖尿病患者最常见和最严重的并发症之一。临床上根据病例特征分为非增殖期糖尿病视网膜病变(NPDR)和增殖期糖尿病视网膜病变(PDR)。目前对于DR的治疗方法主要是手术治疗如视网膜激光光疗、玻璃体切割治疗等。血管内皮生长因子(VEGF)是一种在DR的产生、发展的过程中起着重要作用的蛋白质,VEGF-A与受体VEGFR-2结合促进血管生成。VEGF-B主要与VEGFR-1结合在血管生长或血管通透性方面不发挥重要作用。VEGFC/D 与VEGFR-3结合在淋巴管的生成和转移过程中发挥作用,也可以和VEGFR-2受体结合促进视网膜新生血管生成和通透性增加。本文就DR的病理特征及VEGF家族在DR中的作用进行阐述。
Abstract:
Diabetic retinopathy (DR) is one of the most common and serious complications of diabetic patients.Clinically, it is divided into non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) according to the characteristics of cases.The current treatment methods for DR are mainly surgical treatments such as retinal laser phototherapy and vitrectomy.Vascular endothelial growth factor (VEGF) is a protein that plays an important role in the production and development of DR. VEGF-A combines with the receptor VEGFR-2 to promote angiogenesis.VEGF-B mainly binds to VEGFR-1 and does not play an important role in vascular growth or vascular permeability.The combination of VEGFC/D and VEGFR-3 plays a role in the formation and metastasis of lymphatic vessels, and it can also combine with VEGFR-2 receptor to promote retinal neovascularization and increase permeability.This article describes the pathological characteristics of DR and the role of VEGF family in DR.

参考文献/References:

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更新日期/Last Update: 1900-01-01